A5051945240- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Long-Term Effects of COVID-19
- Systemic Lupus Erythematosus Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Ocular Diseases and Behçet’s Syndrome
- Neuroinflammation and Neurodegeneration Mechanisms
- Glaucoma and retinal disorders
- Autoimmune and Inflammatory Disorders Research
- Stress Responses and Cortisol
- Systemic Sclerosis and Related Diseases
- Advanced Neuroimaging Techniques and Applications
- MicroRNA in disease regulation
- Olfactory and Sensory Function Studies
- Immunotherapy and Immune Responses
- Functional Brain Connectivity Studies
- Polyomavirus and related diseases
- Ophthalmology and Eye Disorders
- Retinal and Optic Conditions
- CNS Lymphoma Diagnosis and Treatment
- Exercise and Physiological Responses
- Transcranial Magnetic Stimulation Studies
- Immune Response and Inflammation
- COVID-19 and Mental Health
- Tryptophan and brain disorders
Charité - Universitätsmedizin Berlin
2016-2025
Humboldt-Universität zu Berlin
2016-2025
Freie Universität Berlin
2017-2025
Max Delbrück Center
2016-2025
Heinrich Heine University Düsseldorf
2024
Korea National Institute of Health
2024
Hudson Institute
2024
John Wiley & Sons (United States)
2024
Scientific Research Institute of Experimental and Clinical Medicine
2022-2023
University of California, San Francisco
2020-2023
Myelin oligodendrocyte glycoprotein antibodies (MOG-IgG) are present in a subset of aquaporin-4 (AQP4)-IgG-negative patients with optic neuritis (ON) and/or myelitis. Little is known so far about brainstem involvement MOG-IgG-positive patients. To investigate the frequency, clinical and paraclinical features, course, outcome, prognostic implications ON Retrospective case study. Among 50 myelitis, 15 (30 %) history encephalitis were identified. All negative for AQP4-IgG. Symptoms included...
Antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) have been reported in patients with aquaporin-4 antibody (AQP4-IgG)-negative neuromyelitis optica spectrum disorders (NMOSD). The objective of this study was to describe optic neuritis (ON)-induced neuro-axonal damage the retina MOG-IgG-positive comparison AQP4-IgG-positive NMOSD patients.Afferent visual system following ON bilaterally assessed 16 a history and compared that patients. In addition, healthy controls matched for...
A subset of patients has long-lasting symptoms after mild to moderate Coronavirus disease 2019 (COVID-19). In a prospective observational cohort study, we analyze clinical and laboratory parameters in 42 post-COVID-19 syndrome (29 female/13 male, median age 36.5 years) with persistent severe fatigue exertion intolerance six months following COVID-19. Further evaluate an age- sex-matched postinfectious non-COVID-19 myalgic encephalomyelitis/chronic comparatively. Most are moderately severely...
Abstract Background Fatigue, exertion intolerance and post-exertional malaise are among the most frequent symptoms of Post-COVID Syndrome (PCS), with a subset patients fulfilling criteria for Myalgic Encephalomyelitis/Chronic Fatigue (ME/CFS). As SARS-CoV-2 infects endothelial cells, causing endotheliitis damaging endothelium, we investigated dysfunction (ED) biomarkers in PCS. Methods We studied function 30 PCS persistent fatigue as well 15 age- sex matched seronegative healthy controls...
To analyze whether 1 of the 2 apheresis techniques, therapeutic plasma exchange (PE) or immunoadsorption (IA), is superior in treating neuromyelitis optica spectrum disorder (NMOSD) attacks and to identify predictive factors for complete remission (CR).This retrospective cohort study was based on registry German Neuromyelitis Optica Study Group, a nationwide network established 2008. It recruited patients with diagnosed according 2006 Wingerchuk criteria aquaporin-4...
Most patients with Post COVID Syndrome (PCS) present a plethora of symptoms without clear evidence organ dysfunction. A subset them fulfills diagnostic criteria myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Symptom severity ME/CFS correlates natural regulatory autoantibody (AAB) levels targeting several G-protein coupled receptors (GPCR). In this exploratory study, we analyzed serum AAB against vaso- and immunoregulatory receptors, mostly GPCRs, in 80 PCS following...
Post-COVID syndrome is a severe long-term complication of COVID-19. Although fatigue and cognitive complaints are the most prominent symptoms, it unclear whether they have structural correlates in brain. We therefore explored clinical characteristics post-COVID fatigue, describe associated imaging changes, determine what influences severity.We prospectively recruited 50 patients from neurological outpatient clinics (age 18-69 years, 39f/8m) matched non-COVID healthy controls between April 15...
Post-COVID-19 syndrome (PCS) is characterised by a wide range of symptoms, primarily fatigue and exertion intolerance. While disease courses in the early months post-infection have been well-described, long-term health consequences for patients with PCS disabling remain unclear.In this prospective observational cohort study, we evaluated symptom severity various biomarkers, including hand grip strength (HGS), cardiovascular function, laboratory parameters, 106 moderate to severe intolerance...
New MRI techniques such as the analysis of magnetization transfer or diffusion have provided evidence for subtle progressive alterations in tissue integrity prior to focal leakage blood-brain barrier (BBB) part plaque formation multiple sclerosis. Since inflammation is capable modulating microcirculation, we investigated hypothesis that changes local perfusion might be one earliest signs lesion development. 20 patients with definite relapsing-remitting sclerosis were analysed regard cerebral...
Sleep disorders can cause tiredness. The relationship between sleep and fatigue in patients with multiple sclerosis (MS) has not yet been investigated systematically.To investigate the MS.Some 66 MS 20 to years old were studied by overnight polysomnography. Using a cut-off point of 45 Modified Fatigue Impact Scale (MFIS), entire cohort was stratified into fatigued subgroup (n=26) non-fatigued (n=40).Of patients, 96% (n=25) suffering from relevant disorder, along 60% (n=24) (p=0.001)....
Background: Axonal and neuronal damage are widely accepted as key events in the disease course of multiple sclerosis. However, it has been unclear to date at which stage evolution neurodegeneration begins whether can occur even absence acute inflammatory attacks. Objective: To characterize inner retinal layer changes patients with clinically isolated syndrome (CIS). Method: 45 CIS age- sex-matched healthy controls were investigated using spectral domain optical coherence tomography....
Neuroaxonal degeneration in the central nervous system contributes substantially to long term disability multiple sclerosis (MS) patients. However, vivo determination and monitoring of neurodegeneration remain difficult. As widely used MRI-based approaches, including brain parenchymal fraction (BPF) have some limitations, complementary measures for are necessary. Optical coherence tomography (OCT) is a potent tool detection MS-related retinal neurodegeneration. crucial aspects association...
Machine learning-based imaging diagnostics has recently reached or even surpassed the level of clinical experts in several domains. However, classification decisions a trained machine learning system are typically non-transparent, major hindrance for integration, error tracking knowledge discovery. In this study, we present transparent deep framework relying on 3D convolutional neural networks (CNNs) and layer-wise relevance propagation (LRP) diagnosing multiple sclerosis (MS), most...
<h3>Objective:</h3> To trace microstructural changes in patients with aquaporin-4 antibody (AQP4-ab)-seropositive neuromyelitis optica spectrum disorders (NMOSDs) by investigating the afferent visual system without clinically overt symptoms or pathway lesions. <h3>Methods:</h3> Of 51 screened NMOSD from a longitudinal observational cohort study, we compared 6 AQP4-ab–seropositive longitudinally extensive transverse myelitis (LETM) but no history of optic neuritis (ON) other bout (NMOSD-LETM)...
Objectives Neuromyelitis optica spectrum disorders (NMOSD) are inflammatory conditions of the central nervous system and an important differential diagnosis multiple sclerosis (MS). Unlike MS, course is usually relapsing, it unclear, if progressive neurodegeneration contributes to disability. Therefore, we aimed investigate retinal neuroaxonal damage occurs in aquaporin4-antibody-seropositive NMOSD. Methods Out 157 patients with NMOSD screened, 94 eyes 51 without optic neuritis (ON) during...
The functional dynamics and cellular sources of oxidative stress are central to understanding MS pathogenesis but remain elusive, due the lack appropriate detection methods. Here we employ NAD(P)H fluorescence lifetime imaging detect NADPH oxidases (NOX enzymes) in vivo identify inflammatory monocytes, activated microglia, astrocytes expressing NOX1 as major nervous system mice affected by experimental autoimmune encephalomyelitis (EAE). This directly affects neuronal function vivo,...
Since recent studies suggested a role of the striatum and prefrontal cortex for multiple sclerosis (MS)-related fatigue, we investigated resting-state functional connectivity alterations striatal subdivisions dorsolateral (dlPFC).Resting-state magnetic resonance imaging was acquired in 77 relapsing-remitting MS patients (38 fatigued (F-MS), 39 non-fatigued (NF-MS)) 41 matched healthy controls (HC). Fatigue severity assessed using fatigue scale. Seed-based analyses were performed subregions...
Abstract Objective Characterization of the clinical features patients with persistent symptoms after mild to moderate COVID-19 infection and exploration factors associated development Chronic Syndrome (CCS). Methods Setting: Charité Fatigue Center immunologists rheumatologist, neurologists cardiologists at University hospital. Participants: 42 who presented severe fatigue six months following a mostly SARS-CoV-2 from July November 2020. Main outcome measures: The primary outcomes were...
Neuromyelitis optica spectrum disorder (NMOSD) is a frequently disabling neuroinflammatory syndrome with relapsing course. Blood-based disease severity and prognostic biomarkers for NMOSD are yet unmet clinical need. Here, we evaluated serum glial fibrillary acidic protein (sGFAP) neurofilament light (sNfL) as in patients aquaporin-4 immunoglobulin (Ig)G positive (AQP4-IgG+) NMOSD.sGFAP sNfL were determined by single-molecule array technology prospective cohort of 33 AQP4-IgG+ NMOSD, 32...
The sequela of COVID-19 include a broad spectrum symptoms that fall under the umbrella term post-COVID-19 condition or syndrome (PCS). Immune dysregulation, autoimmunity, endothelial dysfunction, viral persistence, and reactivation have been identified as potential mechanisms. However, there is heterogeneity in expression biomarkers, it unknown yet whether these distinguish different clinical subgroups PCS. There an overlap pathomechanisms PCS with postinfectious myalgic...
Objective To investigate accumulation of disability in neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein‐antibody‐associated disease (MOGAD) a changing treatment landscape. We aimed to identify risk factors for the development milestones relation duration, number attacks, age. Methods analyzed data from individuals with NMOSD MOGAD German Neuromyelitis Optica Study Group registry. Applying survival analyses, we estimated computed time as defined by...