A5029285539- Cancer Genomics and Diagnostics
- SARS-CoV-2 detection and testing
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- SARS-CoV-2 and COVID-19 Research
- Biosensors and Analytical Detection
- Cancer Research and Treatments
- Ultrasound and Hyperthermia Applications
- Cancer Cells and Metastasis
- Cancer Diagnosis and Treatment
- Optical Imaging and Spectroscopy Techniques
- Cancer Treatment and Pharmacology
- Ocular Oncology and Treatments
- Photoacoustic and Ultrasonic Imaging
- Melanoma and MAPK Pathways
- Intraperitoneal and Appendiceal Malignancies
- Radiomics and Machine Learning in Medical Imaging
- Ethics in Clinical Research
- Respiratory viral infections research
- Colorectal Cancer Screening and Detection
- Advanced biosensing and bioanalysis techniques
- Long-Term Effects of COVID-19
- S100 Proteins and Annexins
- Cancer-related gene regulation
- COVID-19 and Mental Health
Humboldt-Universität zu Berlin
2020-2024
Charité - Universitätsmedizin Berlin
2015-2024
Freie Universität Berlin
2020-2024
German Cancer Research Center
2023
Heidelberg University
2023
Berlin Heart (Germany)
2022
U-M Rogel Cancer Center
2020-2021
Vivantes Klinikum
2021
Zimmer Biomet (Germany)
2015
Max Delbrück Center
2015
Colorectal cancer (CRC) is the second most common cause of all deaths in Europe and Western world with a lifetime risk approximately 5%. Despite several improvements treatment patients unresectable CRC prognosis poor there need developing new strategies for metastatic chemorefractory disease. The S100 calcium binding protein A4 (S100A4) predicts metastasis formation reduced patient survival. S100A4 was previously identified as transcriptional target Wnt/β-catenin signaling pathway. Food Drug...
The sequela of COVID-19 include a broad spectrum symptoms that fall under the umbrella term post-COVID-19 condition or syndrome (PCS). Immune dysregulation, autoimmunity, endothelial dysfunction, viral persistence, and reactivation have been identified as potential mechanisms. However, there is heterogeneity in expression biomarkers, it unknown yet whether these distinguish different clinical subgroups PCS. There an overlap pathomechanisms PCS with postinfectious myalgic...
To assess early- and late-fluorescence near-infrared imaging, corresponding to the vascular (early-fluorescence) extravascular (late-fluorescence) phases of indocyanine green (ICG) enhancement, for breast cancer detection benign versus malignant lesion differentiation.The study was approved by ethical review board; all participants provided written informed consent. Twenty women with 21 lesions were examined imaging before, during, after intravenous injection ICG. Absorption fluorescence...
Abstract Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severely debilitating condition which markedly restricts activity and function of affected people. Since the beginning COVID-19 pandemic ME/CFS related to post-acute (PACS) can be diagnosed in subset patients presenting with persistent 6 months after mostly mild SARS-CoV-2 infection by fulfillment Canadian Consensus Criteria (CCC 2003). Induction autoimmunity viral mechanism under intensive investigation. In...
The additional use of radiotherapy has changed the treatment locally advanced rectal cancer (LARC) dramatically. But a major achievement been development total mesorectal excision (TME) as surgical standard and recognition that surgeon is predominant prognostic factor. benefit preoperative hypofractionated (SCRT; five fractions each 5 Gy), initially established by Swedish Rectal Cancer Trial, demonstrated in conjunction with TME Dutch Colorectal Group. concept combined neoadjuvant...
Metastasis is the most frequent cause of treatment failure and death in colorectal cancer. Early detection tumors metastases crucial for improving strategies patient outcome. Development reliable biomarkers simple tests routinely applicable clinic detection, prognostication, therapy monitoring special interest. We recently identified novel gene Metastasis-Associated Colon Cancer 1 (MACC1), a key regulator HGF/Met-pathway. MACC1 strong prognostic biomarker colon cancer metastasis allows...
Rapid antigen-detecting tests (Ag-RDTs) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can transform pandemic control. Thus far, sensitivity (≤ 85%) of lateral-flow assays has limited scale-up. Conceivably, microfluidic immunofluorescence Ag-RDTs could increase SARS-CoV-2 detection.This multi-centre diagnostic accuracy study investigated performance the LumiraDx™ assay, enrolling symptomatic and asymptomatic participants with suspected infection. Participants collected a...
Using scanning time-domain instrumentation we recorded fluorescence projection mammograms on few breast cancer patients prior, during and after infusion of indocyanine green (ICG), while monitoring arterial ICG concentration by transcutaneous pulse densitometry. Late-fluorescence had been largely cleared from the blood liver, showed invasive carcinomas at high contrast over a rather homogeneous background, whereas benign lesions did not produce (focused) contrast. During infusion, tissue...
Abstract Background Antigen-detecting rapid diagnostic tests (Ag-RDTs) have been widely recommended as a complement to RT-PCR. Considering the possibility of nasal self-sampling and ease-of-use in performing test, self-testing may be an option. Methods Findings We performed manufacturer-independent, prospective accuracy study mid-turbinate when using WHO-listed SARS-CoV-2 Ag-RDT. Symptomatic participants suspected COVID-19 received written illustrated instructions. Procedures were observed...
AIM:To evaluate the diagnostic and prognostic value of circulating Metastasis Associated in Colon Cancer 1 (MACC1) transcripts plasma gastric cancer patients. METHODS:We provide for first time a blood-based assay transcript quantification metastasis inducer MACC1 prospective study patient plasma.MACC1 is strong biomarker tumor progression variety solid cancers.We conducted to define power using 76 samples from patients, either newly diagnosed with cancer, metachronous as well follow-up...
Colorectal cancer is one of the main cancers in Western world. About 90% deaths arise from formation distant metastasis. The expression newly identified gene metastasis associated colon 1 (MACC1) a prognostic indicator for Here, we analyzed first time impact single nucleotide polymorphisms (SNPs) coding region MACC1 clinical outcome colorectal patients. Additionally, screened met proto-oncogene (Met), transcriptional target MACC1, mutations.We sequenced exons 154 tumors (stages I, II and...
Abstract Emerging technologies and progress in data processing allowed for new insights on gene expression, genomics epigenomics, mechanisms of cancer genesis progression. The development therapeutic strategies should therefore be triggered by the understanding underlying biology through sophisticated clinical trials. Therefore, methodology design trials as well methods their implementation are under profound changes. Targeting specific pathways has open hope a more focused personalized...
The metastasis-associated in colon cancer 1 (MACC1) gene has been identified as prognostic biomarker for colorectal (CRC). Here, we aimed at the refinement of risk assessment by separate and combined survival analyses MACC1 expression with any markers KRAS mutated codon 12 (KRAS G12) or 13 G13), BRAF V600 mutation MSI status a retrospective study 99 CRC patients tumors UICC staged I, II III. We showed that only high (HR: 6.09, 95% CI: 2.50-14.85, P < 0.001) G13 5.19, 1.06-25.45, = 0.042)...
Abstract Background The metastasis inducing gene MACC1 is a prognostic and predictive biomarker for in several cancers. Its mechanism of includes the transcriptional control other cancer-related target genes. Here, we investigate interplay with driver S100P CRC progression. Methods MACC1-dependent expression was analysed by qRT-PCR. binding to promoter determined ChIP. Alterations cell proliferation motility were functional vitro assays. In vivo after intrasplenic transplantation assessed...
Abstract Colorectal cancer (CRC) is the second-most common malignant disease worldwide, and metastasis main culprit of CRC-related death. Metachronous metastases remain to be an unpredictable, unpreventable, fatal complication, tracing molecular chain events that lead would provide mechanistically linked biomarkers for maintenance remission in CRC patients after curative treatment. We hypothesized, Metastasis-associated colorectal cancer-1 (MACC1) induces a secretory phenotype enforce...
7081 Background: HDMTX is a key component of treatment protocols for CNSL patients (pts), but impaired renal function in elderly or comorbid pts limits its use. The recombinant enzyme glucarpidase rapidly hydrolyzes MTX into non-toxic metabolites and approved therapeutic use with delayed elimination following HDMTX. We conducted phase I/II study (NCT04841434) to assess the efficacy prophylactic HDMTX-treated impairment history elimination. Methods: A total 18 pre-existing insufficiency...
We present a scanning time-domain fluorescence mammograph capable to image the distribution of fluorescent contrast agent within female breast, slightly compressed between two parallel glass plates, with high sensitivity. Fluorescence is excited using near infrared picosecond diode laser module. Four additional lasers emission wavelengths 660 and 1066 nm allow measure intrinsic optical properties breast tissue. By synchronously moving source fiber seven detection bundles across distributions...