A5024932913- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Colorectal and Anal Carcinomas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Brain Metastases and Treatment
- PI3K/AKT/mTOR signaling in cancer
- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
- Chronic Lymphocytic Leukemia Research
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Lymphoma Diagnosis and Treatment
- Galectins and Cancer Biology
- Artificial Intelligence in Healthcare and Education
- Invertebrate Immune Response Mechanisms
- COVID-19 diagnosis using AI
Wenzhou Medical University
2025
Zhejiang Lab
2025
Jinzhou Kangning Hospital
2025
Fujian Provincial Cancer Hospital
2014-2024
Fujian Medical University
2014-2024
Nanjing Forestry University
2024
Nanjing Medical University
2021
Nanjing University
2021
Jiangsu Province Hospital
2021
Zhejiang Chinese Medical University
2021
Aberrant activation of Bruton's tyrosine kinase (BTK) plays an important role in pathogenesis B-cell lymphomas, suggesting that inhibition BTK is useful the treatment hematological malignancies. The discovery a more selective on-target covalent inhibitor high value. Herein, we disclose and preclinical characterization potent, selective, irreversible as our clinical candidate by using vitro potency, selectivity, pharmacokinetics (PK), vivo pharmacodynamic for prioritizing compounds. Compound...
// Gen Lin 1 , Xirong Fan Weifeng Zhu 2 Cheng Huang Wu Zhuang Haipeng Xu Xiandong 3 Dan Hu Yunjian Kan Jiang Qian Miao and Chao Li 2, 4 Department of Thoracic Oncology, Fujian Cancer Hospital, Medical University Fuzhou 350014, China Pathology, Molecular Provincial Key Laboratory Translational Medicine, Correspondence to: Li, email: lichao3501@163.com Keywords: non-small cell lung cancer, prognosis, programmed death ligand 1, tumor infiltrating lymphocytes Received: June 20, 2017 Accepted:...
Abstract Immune checkpoint inhibitor (ICI) rechallenge in non‐small cell lung cancer (NSCLC) is a promising therapeutic strategy. The situation for ICI can be divided into three categories: adverse events (AEs); resistance to ICIs, and becomes compulsive because of tumor relapse while the patients had completed 2 year course immunotherapy. However, these categories are still controversial should explored further. Through voting at 6th Straits Summit Forum on Lung Cancer, this study we...
Different anti-PD-1 and anti-PD-L1 antibodies bind different epitopes. However, whether the results from SP142 22C3 immunochemistry (IHC) assays can be interchanged to determine patient eligibility for immunotherapy remains largely unknown. Histologic sections 135 tumor samples were probed with both antibodies. The concordance of PD-L1 expression determined by two was assessed. Additionally, we evaluated association detected clinicopathological features prognosis. In total, 105 (77.78%)...
Non-small cell lung cancer (NSCLC) accounts for approximately 80-85% of all cancers, with the FAS-associated factor 1 (FAF1) acting as a tumor suppressor. MicroRNAs (miRNAs) can influence progression by targeting oncogenes or anti-oncogenes. In this study, we aimed to reveal miR-26a-5p on regulation FAF1 expression and NSCLC progression, motivation identifying potential therapeutic target treatment.A dual-luciferase reporter assay was used check direct miR-26a-3p. The inhibitor shRNA plasmid...
This study aimed to examine the association of clinical prognostic factors with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) efficacy in advanced non-small-cell lung cancer (NSCLC) patients.The demographic and characteristics 94 patients stage IV NSCLC were retrospectively reviewed, between EGFR-TKIs was evaluated.Of enrolled this study, a 74.5% objective response rate (ORR) 97.9% disease control (DCR) observed for treatment, higher ORR seen 0 1 ECOG scores than...
ABSTRACT Objectives To compare preparation time and 1-year Invisalign aligner attachment survival between a flowable composite (FC) packable (PC). Materials Methods Fifty-five participants (13 men 42 women, mean age ± SD: 24.2 5.9 years) were included in the study. Ipsilateral quadrants (ie, maxillary mandibular right, or vice versa) of attachments randomly assigned to FC group (Filtek Z350XT Flowable Restorative) PC Universal by tossing coin. The primary outcome was time. secondary first...
Circular RNA (CircRNA) is related to tumor development. Nevertheless, the regulation and function of hsa_circ_0006692 its interactions with miR-205-5p CDK19 in development non-small-cell lung cancer (NSCLC) were un-explored. The correlations expression levels NSCLC specimens cells pathological characteristics studied. assessed real-time PCR, RNA-binding protein immunoprecipitation (RIP), luciferase reporter, pull-down, fluorescence situ hybridization (FISH). roles on cell growth, invasion,...
Abstract The ability to evade apoptosis is a hallmark of cancer. B-cell lymphoma-2 (Bcl-2), an anti-apoptosis protein, overexpressed and leads oncogenesis or drug resistance in various tumor types, including lymphoma leukemia. Bcl-2 well-validated target for B cell malignancies as demonstrated by inhibitor venetoclax which was recently approved the treatment chronic lymphocytic leukemia (CLL) currently phase III clinical development other hematologic malignancies. With longer term treatment,...
miR-214 has been reported to contribute erlotinib resistance in non-small-cell lung cancer (NSCLC) through targeting LHX6; however, the molecular mechanisms underlying involvement of LHX6 mediating EGFR-TKIs erlotinib-resistant NSCLC HCC827 (HCC827/ER) cells remain unknown. This study aimed investigate responsible for contribution HCC827/ER cells.HCC827/ER were generated by treatment at a dose-escalation scheme. knockout or overexpression was modeled and cells, then IC50 values measured. The...
Despite the excellent efficacy and low toxicity of photoresponse therapy, which has attracted considerable attention for use in non-small cell lung cancer (NSCLC) unsatisfactory cellular permeability, instability, both vitro vivo have limited further clinical applications indole cyanine photosensitizers. Here, we explore supramolecular self-assembly a 'hyalurosome' that is mediated by calcium phosphate nanonuclei. Through hyaluronate-mediated CD44 targeting, constructed hyalurosome...
The objectives of this study were to evaluate meat colour, antioxidant performance longissimus muscle in different pig breeds, including five Chinese native a bred breed as well commercial crossbred breed, and analyse the relationships between colour capacity. results showed that breeds have higher marbling scores than pigs. significantly stronger total capacity superoxide dismutase activity, lower malondialdehyde contents Moreover, capacity, activity positively correlated with visual a*...
Background Cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME) are critical for immune suppression by restricting cell infiltration in stromal zones from penetrating islands and changing their function status, particularly CD8 + T cells. However, assessing quantifying impact of CAFs on cells investigating how this is related to clinical outcomes, especially efficacy immunotherapy, remain unclear. Materials methods The TME was characterized using immunohistochemical...
Programmed death-ligand 1 (PD-L1) expression as measured by immunohistochemistry (IHC) has been employed to predict the efficacy of anti-PD-1/PD-L1 therapy. Nevertheless, heterogeneous PD-L1 represents a challenge for selection patients therapy.PD-L1 using clone 22C3 in 76 resected non-small-cell lung cancer and paired nodal metastases was assessed classified according proportion immunostained tumour cells cutoff values 1%, 5%, 50%.The concordance rates between primary metastatic lymph nodes...
Abstract Nuclear factor‐kappa B ( NF ‐κB) as a prognostic marker remains unclear in non‐small cell lung cancer NSCLC ). Here, we studied ‐κB‐p65 (p65) expression and phosphorylated ‐κB‐p105 (p‐p105) correlated the finding with overall survival OS ) clinicopathological features. A total of 186 archival samples from patients surgically resectable were probed p65 p‐p105 (Ser 932). The p65‐positive p‐p105‐positive defined distinct nuclear cytoplasmic labelling at least 1% tumour cells,...