Huihua Hu

ORCID: 0000-0003-2521-8113
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About
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Research Areas
  • Rock Mechanics and Modeling
  • Landslides and related hazards
  • Aquaculture Nutrition and Growth
  • Geotechnical Engineering and Analysis
  • Tunneling and Rock Mechanics
  • RNA modifications and cancer
  • Lung Cancer Diagnosis and Treatment
  • Soil and Unsaturated Flow
  • Epigenetics and DNA Methylation
  • Aquaculture disease management and microbiota
  • Structural Response to Dynamic Loads
  • Reproductive biology and impacts on aquatic species
  • Radiomics and Machine Learning in Medical Imaging
  • Geophysical Methods and Applications
  • Geotechnical Engineering and Underground Structures
  • Lung Cancer Research Studies
  • Geomechanics and Mining Engineering
  • AI in cancer detection
  • Lung Cancer Treatments and Mutations
  • COVID-19 diagnosis using AI
  • Cancer-related molecular mechanisms research
  • Geotechnical Engineering and Soil Mechanics
  • Physiological and biochemical adaptations
  • Geotechnical Engineering and Soil Stabilization
  • Civil and Geotechnical Engineering Research

Chengdu Women's and Children's Central Hospital
2023-2025

Chengdu Medical College
2023-2025

Fujian Medical University
2016-2024

Hunan Communications Research Institute
2009-2024

Fujian Provincial Cancer Hospital
2016-2024

Central South University
2022-2024

Hubei University of Medicine
2018-2022

Communication University of Zhejiang
2022

Suizhou Central Hospital
2012-2021

Institute of Hydrobiology, Biology Centre, Academy of Sciences of the Czech Republic
2020

The soft interlayer and rock structure play a significant role in controlling the deformation of bedding slope, it is necessary to consider phenomenon sudden change local response these key parts under rainfall conditions, then clarify mechanism infiltration damage such slopes. In this paper, large red-layered flat-dipping landslide was selected as research object, numerical calculations based on Van Genuchten model for saturated–unsaturated flow were performed order investigate hydrological...

10.3390/app14041394 article EN cc-by Applied Sciences 2024-02-08

Abstract DNA methylation is an important epigenetic mechanism involved in many biological processes, i . e gametogenesis and embryonic development. However, increased copy numbers of related genes ( dnmt , tet tdg ) have been found during chordate evolution due to successive whole genome duplication (WGD) events. Their evolutionary history phylogenetic relationships remain unclear. The present study the first clarify chordates. In particular, our results highlight fixation several dnmt3...

10.1038/s41598-020-57753-w article EN cc-by Scientific Reports 2020-01-22

To study the combined action of joints and bedding plane on crack evolution flawed layered rock masses, uniaxial compression tests digital image correlation (DIC) were carried out double-layer composite rock-like specimens with multi-inclination two coplanar under different angles. Based experimental results, existence performs a significant effect characteristics stress-strain curves strength parameters. The failure modes are divided into four types. inhibits coalescence cracks in bridge...

10.1016/s1003-6326(23)66300-9 article EN Transactions of Nonferrous Metals Society of China 2023-09-01

The rock or mass in engineering often contains joints, fractures, voids, and other defects, which are the root cause of local overall failure. In response to most current constitutive models that fail simulate nonlinear fracture compaction deformation whole process failure, especially brittle rocks, a piecewise model was proposed represent global relation rocks this study, composed empirical damage statistical model. determined by fitting expressions closure curves various while evolution...

10.3390/ma16020589 article EN Materials 2023-01-07

The stability of the interface between mortar and rock is very important in engineering construction. In this paper, all-digital acoustic emission (AE) system used to detect direct shear test mortar-rock binary medium with different sawtooth angles under normal stress states. stress-displacement information AE signal during whole shearing process are extracted. coupling relationship characteristic parameters discussed. quantitative angle strength established, three that can be predict...

10.3390/buildings12050665 article EN cc-by Buildings 2022-05-17

Introduction The prognosis of granulomatous lobular mastitis (GLM) had been poor, primarily due to the lack a unified disease assessment standard. Objective purpose this cohort study was establish staging system for GLM more accurately evaluate patients. Methods This retrospectively collected data from 264 patients who visited our hospital between January 2017 and December 2023. Through logistic regression analysis, factors associated with were identified, which served as basis creating new...

10.1371/journal.pone.0319956 article EN cc-by PLoS ONE 2025-03-19

Sustainable aquaculture production requires a greater reduction in the use of marine-derived ingredients, and one most promising solutions today is augmentation proportion digestible carbohydrates aquafeed. This challenge particularly difficult for high trophic level teleost fish as they are considered to be glucose-intolerant (growth delay persistent postprandial hyperglycemia observed juveniles fed diet containing more than 20% carbohydrates). It was previously suggested that broodstock...

10.3389/fphys.2020.00303 article EN cc-by Frontiers in Physiology 2020-05-15

As the strength parameters of rock mass degrade differently during slope instability, different factors should be considered in reduction method. Previous nonlinear methods were essentially implemented based on Mohr–Coulomb criterion, which was reported not to reflect performance mass. To address this deficiency, study, Hoek–Brown criterion combined with a technique for stability evaluation. Firstly, classical definition safety factors, relationships that satisfied by each parameter critical...

10.3390/ma16072793 article EN Materials 2023-03-31

Understanding the shear mechanics mechanism of bolted joints is great significance for predicting and preventing geological disasters. Most current studies seldom consider rheological effects joints. In this paper, a comprehensive constitutive model proposed, accounting initial damage evolution across different stages bolt characteristics. The incorporates an elastoplastic Hooke body instantaneous deformation, parametric nonlinear Kelvin viscous models attenuation steady creep stages,...

10.1177/10567895231183468 article EN International Journal of Damage Mechanics 2023-06-29

Rock mass, the heterogeneous natural material composed of rock and discontinuities, is an important part engineering construction. Discontinuities affect mechanical properties mass further threaten stability engineering. To study failure characteristics anchored structure plane with different JRC, jointed specimens four JRC were fabricated by pouring cement mortar. Specimens tested under normal loads to figure out how anchorage angle plane. Besides, acoustic emission (AE) testing technology...

10.3390/ma15124169 article EN Materials 2022-06-12

Introduction Many researchers used machine learning (ML) to predict the prognosis of breast cancer (BC) patients and noticed that ML model had good individualized prediction performance. Objective The cohort study was intended establish a reliable data analysis by comparing performance 10 common algorithms traditional American Joint Committee on Cancer (AJCC) stage, this in Web application development provide for others. Methods This included 63145 BC from Surveillance, Epidemiology, End...

10.1371/journal.pone.0280340 article EN cc-by PLoS ONE 2023-01-26

10.1016/s1003-6326(11)61041-8 article EN Transactions of Nonferrous Metals Society of China 2011-11-01

This study aimed to examine the association of clinical prognostic factors with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) efficacy in advanced non-small-cell lung cancer (NSCLC) patients.The demographic and characteristics 94 patients stage IV NSCLC were retrospectively reviewed, between EGFR-TKIs was evaluated.Of enrolled this study, a 74.5% objective response rate (ORR) 97.9% disease control (DCR) observed for treatment, higher ORR seen 0 1 ECOG scores than...

10.18632/oncotarget.13787 article EN Oncotarget 2016-12-03

Retrogressive landslide is caused by the lower rock mass sliding, so that upper part loses support, deformed, and starts to slide. In process of highway construction, incised slope often leads retrogressive landslide, determination damage range great significance for control slope. Taking a in Hunan Province as research object, particle flow discrete element used numerically simulate entire failure According complex geological conditions slope, each model divided, displacement key parts...

10.3390/app13020799 article EN cc-by Applied Sciences 2023-01-06

Lung cancer has one of the highest mortality rates malignant neoplasms. adenocarcinoma (LUAD) is most common types lung cancer. DNA methylation more stable than gene expression and could be used as a biomarker for early tumor diagnosis. This study aimed to screen potential signatures facilitate diagnosis prognosis LUAD integrate data identify functional epigenetic modules. We systematically integrated from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO), bioinformatic models...

10.1590/1678-4685-gmb-2019-0164 article EN cc-by Genetics and Molecular Biology 2020-01-01
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