A5021026358- Cancer, Hypoxia, and Metabolism
- Landslides and related hazards
- Geotechnical Engineering and Analysis
- Cancer-related molecular mechanisms research
- Traffic and Road Safety
- Virus-based gene therapy research
- RNA modifications and cancer
- Advanced Cellulose Research Studies
- Occupational Health and Safety Research
- Cultural Heritage Materials Analysis
- Reproductive Biology and Fertility
- Cytokine Signaling Pathways and Interactions
- Diet and metabolism studies
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- Rock Mechanics and Modeling
- Bone Metabolism and Diseases
- Material Properties and Processing
- Bone health and treatments
- Phosphodiesterase function and regulation
- Immune Response and Inflammation
- Alzheimer's disease research and treatments
- Receptor Mechanisms and Signaling
- Hemoglobinopathies and Related Disorders
- Urticaria and Related Conditions
Hangzhou Medical College
2018-2025
Zhejiang Provincial People's Hospital
2015-2025
Army Medical University
2020-2025
Daping Hospital
2019-2025
Hunan University of Traditional Chinese Medicine
2025
Central South University
2021-2024
Capital Medical University
2019-2024
Fudan University
1998-2023
Hunan Provincial Center for Disease Control and Prevention
2023
National Engineering Research Center of Human Stem Cells
2023
Abstract Osteocytes, entrapped within the mineralized bone matrix, has been found to have numerous functions such as acting an orchestrator of remodeling through regulation both osteoclast and osteoblast activity also functioning endocrine cell. Due a specialized morphology surrounding structure, osteocytes are more tolerant hypoxia during osteoporosis, fracture, osteoarthritis, orthodontic–orthognathic combination therapy. Hypoxia‐inducible factor‐1α (HIF‐1α) is one master regulators...
PURPOSE: To determine the histologic basis of perfusion parameters measured at functional computed tomography (CT) and to examine relationship between changes in after antiangiogenic therapy a rat model. MATERIALS AND METHODS: This study had institutional animal care use committee approval. Among 20 Fischer rats with implanted FN13762 tumors liver, 10 were treated SU5416, tyrosine kinase inhibitor vascular endothelial growth factor receptor, diluent only as control rats. Six chosen random...
Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) functions as a crucial regulator of metastasis in cancer. The aim this study is to unravel the underlying mechanisms lncRNA MALAT1 non-small-cell cancer (NSCLC). A cohort 36 NSCLC tumor tissues and adjacent normal was collected postoperatively from patients with NSCLC. qRT-PCR performed detect expression both cell lines. Cell migration invasion were monitored by wound healing assay transwell assay....
Pemphigus vulgaris (PV) is a kind of IgG-mediated autoimmune blistering disease (AIBD) that characterized by loss keratinocyte adhesion in the epithelium mucous membranes or skin. Recently, pemphigus was thought to be associated with classical T helper 2 (TH2)-type cytokines such as interleukin-4 (IL-4) and interleukin-17 (IL-17) signaling pathway. A humanized monoclonal IgG4 antibody called dupilumab binds alpha subunit receptor (IL-4Rα) inhibits IL-4 interleukin-13 (IL-13), which has been...
Repeated bouts of ischemia in the heart lead to fibrosis and eventually failure. Although certain genes, such as SOD or hemoxygenase antisense AT 1 R, ACE, (β -AR can provide short-term protection from ischemia, there is no known mechanism for constantly responding repeated incidences ischemia. We hypothesized that a “vigilant vector,” designed be expressed specifically switch on therapeutic genes only during hypoxia, would cardioprotection. To attain cardiac specificity, we inserted an...
Although human heme oxygenase-1 (hHO-1) could provide a useful approach for cellular protection in the ischemic heart, constitutive overexpression of hHO-1 may lead to unwanted side effects. To avoid this, we designed hypoxia-regulated gene therapy system that can be switched on and off. This vigilant plasmid is composed myosin light chain-2v promoter switch based an oxygen-dependent degradation domain from hypoxia inducible factor-1-α. The vector sense ischemia system, specifically heart....
Rous sarcoma virus (RSV) budding requires an interaction of the L domain within p2b region Gag with cellular Nedd4-family E3 ubiquitin protein ligases. Members our laboratories previously demonstrated that overexpression a fragment chicken Nedd4-like (LDI-1 WW) inhibits release in dominant-negative manner (A. Kikonyogo, F. Bouamr, M. L. Vana, Y. Xiang, A. Aiyar, C. Carter, and J. Leis, Proc. Natl. Acad. Sci. USA 98:11199-11204, 2001). We have now identified complete 3' end LDI-1 determined...
Abstract Peptidoglycan (PGN) is a potent immune adjuvant derived from bacterial cell walls. Previous investigations suggest that intestinal epithelium may absorb PGN the lumen. Nonetheless, how taken up and crosses remains largely unclear. Here, we first characterized transport in vitro using IEC‐18 HT29‐CL19A cells, which represent less mature epithelial cells crypts. With fluorescent microscopy, visualized internalization of dual‐labeled by enterocytes. Engulfed was found to form complex...
Abstract The presence and extent of regional lymph node distant metastasis are the most fatal prognostic factors in penile squamous cell carcinoma (PSCC). However, available biomarkers detailed mechanisms underlying PSCC remain elusive. Here, we explored expression landscape HOX genes twelve paired tissues, including primary tumors, metastatic nodes corresponding normal highlighted that HOXD11 was indispensable progression PSCC. upregulated lines especially nodes. High associated with...
Roux-en-Y gastric bypass (RYGB) results in glucose-lowering patients with type 2 diabetes mellitus (T2DM) and may be associated increased intestinal glucose excretion. However, the contribution of excretion to glycemic control after RYGB its underlying mechanisms are not fully elucidated. Here, we confirmed that significantly obese rats RYGB, which was negatively correlated postoperative blood levels. Moreover, also found Biliopancreatic limb length, an important factor affecting improvement...
Integrating International Council for Harmonisation Good Clinical Practice (ICH GCP) principles, including essential documentation and ethical standards, into medical education is crucial building clinical trial capabilities advancing research literacy. However, dermatology residency programs in China currently lack a formal framework incorporating these principles. This perspective article proposes three-module curriculum tailored to address this gap align Chinese with international...
The functionally exchangeable L domains of HIV‐1 and Rous sarcoma virus (RSV) Gag bind Tsg101 Nedd4, respectively. Nedd4 function in endocytic trafficking, studies show that expression or fragments interfere with release RSV Gag, respectively, as virus‐like particles (VLPs). To determine whether functional exchangeability reflects use the same trafficking pathway, we tested effect on co‐expression mutated forms Vps4, Tsg101. A dominant‐negative mutant Vps4 , an AAA ATPase required for...
Abstract The rapid bone remodeling after osteotomy has been reported for a long time. However, the underlying mechanism promoting active reconstruction was still to be elucidated. Since not only bone, blood vessels, and supportive tissues, but also local microenvironment were destroyed, if changes on cell metabolism contributed accelerated came into sight. In present study, we found that mandibular in rabbit activated osteoclasts, as well expression of hypoxia‐inducible factor 1α (HIF‐1α)...