A5034123531- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Autism Spectrum Disorder Research
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Botulinum Toxin and Related Neurological Disorders
- Eicosanoids and Hypertension Pharmacology
- Pulmonary Hypertension Research and Treatments
- Peroxisome Proliferator-Activated Receptors
- Heart Rate Variability and Autonomic Control
- Nicotinic Acetylcholine Receptors Study
- Genetics and Neurodevelopmental Disorders
- Diet and metabolism studies
- Obsessive-Compulsive Spectrum Disorders
- Anesthesia and Neurotoxicity Research
- Cardiovascular Function and Risk Factors
- Synthesis and pharmacology of benzodiazepine derivatives
- Medicinal Plants and Bioactive Compounds
- Renin-Angiotensin System Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Congenital heart defects research
- Ginseng Biological Effects and Applications
- Alkaloids: synthesis and pharmacology
- Transcranial Magnetic Stimulation Studies
Wenzhou Medical University
2013-2025
First Affiliated Hospital of Wenzhou Medical University
2013-2025
Harbin Medical University
2025
Chongqing Medical University
2021-2025
Children's Hospital of Chongqing Medical University
2025
Second Affiliated Hospital of Harbin Medical University
2025
Second Affiliated Hospital of Jilin University
2014-2024
Leipzig University
2024
Sichuan University
2004-2020
West China Hospital of Sichuan University
2004-2020
Causes of autism are still unknown. Some studies have shown that might be associated with metabolic abnormalities in the folate/homocysteine pathway, which is involved DNA methylation, thus altering gene expression. The association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms and risk controversial ambiguous. purpose this study was to examine effect MTHFR polymorphism on Chinese Han population. A population-based case-control conducted 186 children controls. were...
ABSTRACT Due to considerable tumour heterogeneity, stomach adenocarcinoma (STAD) has a poor prognosis and varies in response treatment, making it one of the main causes cancer‐related mortality globally. Recent data point significant role for metabolic reprogramming, namely dysregulated lactic acid metabolism, evolution STAD treatment resistance. This study used series artificial intelligence‐related approaches identify IGFBP7, Schlafen family member, as critical factor determining...
Objective This study aimed to evaluate the safety profile of sevoflurane in pediatric populations using real-world data. Methods Data were extracted from Food and Drug Administration Adverse Event Reporting System (FAERS) first quarter 2004 third 2024. We analyzed reports where was primary suspect individuals aged 0–18, employing disproportionality analysis detect adverse events associated with sevoflurane. also compared related between adult populations. Results The FAERS database yielded...
Pulmonary arterial hypertension (PAH) is a life-threatening chronic cardiopulmonary disease. However, there paucity of studies that reflect the available biomarkers from separate gene expression profiles in PAH. The GSE131793 and GSE113439 datasets were combined for subsequent analyses, batch effects removed. Bioinformatic analysis was then performed to identify differentially expressed genes (DEGs). Weighted co-expression network (WGCNA) protein-protein interaction (PPI) used further filter...
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disease featuring executive control deficits as prominent neuropsychological trait. Executive functions are implicated in multiple sub-networks of the brain; however, few studies examine these whole ADHD. By combining resting-state functional MRI and graph-based approaches, we systematically investigated connectivity patterns among four control-related networks, including frontoparietal network (FPN),...
Objective: This study aimed to explore alterations of seed-based functional connectivity (FC) in dorsal attention network (DAN), ventral (VAN), and default mode (DMN) ADHD children. Method: A voxel-based comparison FC maps between 46 drug-naïve children with 31 healthy controls (HCs) correlation analysis features behavior were performed. Results: Compared the HCs, characterized by hyperconnectivity DAN regions DMN a set involved somatosensory, visual, auditory cortices. No significant group...
Abstract Attention-deficit/hyperactivity disorder has been identified to involve the impairment of large-scale functional networks within grey matter, and recent studies have suggested that white which also encodes neural activity, can manifest intrinsic organization similar matter. However, alterations in matter attention-deficit/hyperactivity remain unknown. We recruited a total 99 children, including 66 drug-naive patients 33 typically developing controls aged from 6 14, characterize...
Autism spectrum disorders (ASD) are a family of childhood-onset neurodevelopmental with complex genetic mechanisms underlying their aetiology. The aim this case-control study was to evaluate the effect catechol-O-methyltransferase (COMT) gene Val158Met polymorphism on ASD risk in Chinese Han population.The COMT detected by polymerase chain reaction-restriction fragment length children (≤ 18 years old) and healthy control subjects.The frequency Val158/Val158 genotype (22/186; 11.8%)...
The dopamine D4 receptor gene (DRD4) has been consistently reported to be associated with attention-deficit/hyperactivity disorder (ADHD). Recent studies have linked DRD4 functional connectivity among specific brain regions. current study aimed compare the effects of genotype on integrity in drug-naïve ADHD children and healthy children. Resting-state MRI images were acquired from 49 37 controls (HCs). We investigated 2-repeat allele network both groups using a parameter called degree...
The specific role of the corticospinal tract with respect to inattention and impulsive symptoms in children attention-deficit/hyperactivity disorder (ADHD) has been explored past. However, our knowledge, no study identified exact regions that are affected ADHD. We aimed determine comprehensive alterations white matter microstructure underlying neuropsychological substrates ADHD.We recruited 38 drug-naïve ADHD 34 typically developing controls. employed a tract-based quantitative approach...
Objective To analyze the correlation between susceptibility single nucleotide polymorphisms (SNPs) and severity of clinical symptoms in children with attention deficit hyperactivity disorder (ADHD), so as to supplement significance gene polymorphism increase our understanding association genetic mutations ADHD phenotypes. Methods 193 were included study from February 2017 2020 Children’s Clinic author’s medical institution. 23 SNPs selected based on literature, multiple polymerase chain...
Objective. Genetic variation, especially polymorphism of the dopamine D4 receptor gene (DRD4), has been linked to deficits in self-regulation and executive functions attention deficit hyperactivity disorder (ADHD), is related structural functional integrity default mode network (DMN), control (ECN) sensorimotor (SMN). The aim this study was explore effects 2-repeat allele DRD4 on brain connectivity behaviors children with ADHD. Methods. Using independent component analysis dimension...