A5016088625- Vitamin D Research Studies
- Cardiovascular Health and Disease Prevention
- Atrial Fibrillation Management and Outcomes
- Nutritional Studies and Diet
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Cardiac Arrhythmias and Treatments
- Head and Neck Cancer Studies
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Cardiac electrophysiology and arrhythmias
- Nutrition, Genetics, and Disease
- Heart Rate Variability and Autonomic Control
- Biomarkers in Disease Mechanisms
- Acute Myocardial Infarction Research
- Potassium and Related Disorders
- Diabetes Treatment and Management
- Heart Failure Treatment and Management
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Risk Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Vitamin C and Antioxidants Research
- Lymphatic System and Diseases
Hospital Authority
2020-2025
Queen Mary Hospital
2016-2025
University of Hong Kong
2016-2025
Addenbrooke's Hospital
2023-2025
University of Cambridge
2023-2025
Papworth Hospital
2024-2025
Chinese University of Hong Kong
2008-2024
Chi Mei Medical Center
2024
University of Hong Kong - Shenzhen Hospital
2022-2024
Cambridge University Hospitals NHS Foundation Trust
2024
Vitamin D (Vit-D) deficiency is associated with type 2 diabetes mellitus (DM) and endothelial dysfunction. The relationship of Vit-D circulating progenitor cells dysfunction in DM patients nonetheless remains unclear.We aimed to investigate the cross-sectional association status brachial flow-mediated dilation (FMD) cell (EPC) numbers patients.We conducted a study 280 (59% male, aged 68 ± 10 yr) recruited outpatient clinics during winter period.We measured serum 25-hydroxyvitamin [25(OH)D]...
AimsTo investigate the effect of oral isoflavone supplement on vascular endothelial function in patients with established cardiovascular disease.
Cardiovascular disease (CVD) is a major contributor to the global burden of disease. Berberine, long-standing, widely used, traditional Chinese medicine, thought have beneficial effects on CVD risk factors and in women with polycystic ovary syndrome. The mechanisms effects, specifically men, possibly via testosterone, not been examined previously. To assess effect berberine any potential pathway testosterone we conducted randomized, double-blind, placebo-controlled, parallel trial Hong Kong....
Metabolic reprogramming of energy processes is a cellular hallmark various cancers. Whether trimetazidine, an anti-ischemic agent that preferentially potentiates glucose oxidation, alters the long-term risk malignancies unknown. In this multi-center, retrospective cohort study, we studied effect trimetazidine on new-onset in 200,563 ischemic heart disease patients (mean age 70.8 years, 46.6% female) using Hong Kong Clinical Data Analysis and Reporting System (CDARS), comparing users (n =...
Background/Objective: High-risk subsets of patients with acute coronary syndrome (ACS) experience decreased access to optimal care and have poor clinical outcomes, reflecting an inertia the delivery guideline-directed evidence-based therapy implementation critical pathways. We aim investigate effectiveness a simplified checklist counter treatment in high comorbidity burden. Methods: An ACS pathway was reduced minimalistic including only items on GDMT invasive strategy. A total 2005...
Intracranial haemorrhage (ICH) accounts for ~35% of all strokes in Chinese. Anti-platelet agent is often avoided after an index event due to the possibility recurrent ICH. This single-centered observational study included 440 consecutive Chinese patients with a first spontaneous ICH surviving month performed during 1996-2010. The subjects were identified, and their clinical characteristics, anti-platelet therapy ICH, outcomes including ischaemic stroke, acute coronary syndrome checked from...
Type 2 diabetes mellitus (T2DM) patients are at increased risk of developing cardiovascular events. Unfortunately traditional assessment scores, including the Framingham Risk Score (FRS), have only modest accuracy in prediction these patients.We sought to determine prognostic values different non-invasive markers atherosclerosis, brachial artery endothelial function, carotid atheroma burden, ankle-brachial index, arterial stiffness and computed tomography coronary calcium score (CACS) 151...
Studies on serum vitamin D in smokers showed conflicting results. We examined the association of smoking status with older Chinese men, taking advantage a community-based sample natural exposure to D.Cross-sectional study based Guangzhou Biobank Cohort Study (GBCS).Community-based from Study.612 male participants aged 50+years recruited 2009 2011.The mean (SD) concentration was 58.3 (17.2), 57.0 (15.0) and 54.7 (15.4) nmol/L for never, former current smokers, respectively. Adjusted multiple...
Type 2 diabetes mellitus (T2DM) is associated with subclinical myocardial injury although the underlying mechanism uncertain. We postulated that arterial stiffness, endothelial dysfunction and atherosclerosis may contribute to in patients T2DM.Serum high-sensitivity troponin I (hs-TNI) an indicator of injury, was measured 100 T2DM without clinical evidence macrovascular disease 150 age gender-matched controls. Elevated hs-TnI defined as follow (derived from 99th percentile controls): Male...
High-sensitivity cardiac troponin I(hs-TnI) and T levels(hs-TnT) are sensitive biomarkers of cardiomyocyte turnover or necrosis. Prior studies the predictive role hs-TnT in type 2 diabetes mellitus(T2DM) patients have yielded conflicting results. This study aimed to determine whether hs-TnI, which is detectable a higher proportion normal subjects than hsTnT, associated with major adverse cardiovascular event(MACE) T2DM patients. We compared hs-TnI level stored serum samples from 276...
Background: Patients with myocardial infarction (MI) are at risk of the development atrial fibrillation (AF) and ischemic stroke. We sought to evaluate prognostic performance CHADS 2 CHA DS -VASc scores in predicting new AF and/or stroke post-ST segment elevation MI (STEMI) patients. Six hundred seven consecutive post-STEMI patients no previously documented were studied. Methods Results: After a follow-up 63 months (3,184 patient-years), 83 (13.7%) developed (2.8% per year). high score more...
The Mediterranean-style diet has been associated with a reduced risk of cardiovascular events as well all-cause mortality among individuals and without diseases (CVD). 1,2][5][6] Recently, outpatient clinic visit-to-visit blood pressure variability (BPV) identified novel factor for the development cerebrovascular diseases. 7,8An elevated BPV also significantly predicts mortality, independent average BP control. 9,10Factors that have noted to be an increased include arterial stiffness, poor...
Summary The COVID‐19 pandemic has increased the demand for disposable N95 respirators. Re‐usable elastomeric respirators may provide a suitable alternative. Proprietary respirator filters become depleted as increases. An alternative be virus/bacterial used in anaesthesia circuits, if they can adequately fitted onto In addition, many re‐usable do not filter exhaled breaths. If sterile procedures, this would also require modification. We designed 3D‐printed adaptor that permits to interface...