A5089830546- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Infective Endocarditis Diagnosis and Management
- Peripheral Artery Disease Management
- Angiogenesis and VEGF in Cancer
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Imaging and Diagnostics
- Cardiac Fibrosis and Remodeling
- Cardiac Arrest and Resuscitation
- COVID-19 and healthcare impacts
- Pediatric health and respiratory diseases
- Vascular Procedures and Complications
- Lipoproteins and Cardiovascular Health
- Venous Thromboembolism Diagnosis and Management
- Restraint-Related Deaths
- Constructed Wetlands for Wastewater Treatment
- Abdominal Trauma and Injuries
- Scoliosis diagnosis and treatment
- Systemic Lupus Erythematosus Research
Karolinska Institutet
2023-2025
Queen Mary Hospital
2014-2023
University of Hong Kong
2013-2023
Chinese University of Hong Kong
1997-2020
Columbia University Irving Medical Center
2016-2018
Cardiovascular Research Foundation
2016-2018
New York Hospital Queens
2018
NewYork–Presbyterian Hospital
2018
Asan Medical Center
2017
Lukaskrankenhaus
2016
Abstract Objective To determine whether COVID‐19 may adversely affect outcome of myocardial infarction (MI) patients in Hong Kong, China. Background The pandemic has infected thousands people and placed enormous stress on healthcare system. Apart from being an infectious disease, it human behavior resource allocation which potentially cause treatment delay MI. Methods This was a single center cross‐sectional observational study. From November 1, 2019 to March 31, 2020, we compared admitted...
Background: It is unknown whether the direct oral anticoagulant edoxaban can reduce leaflet thrombosis and accompanying cerebral thromboembolic risk after transcatheter aortic valve replacement. In addition, causal relationship of subclinical with thromboembolism neurological or neurocognitive dysfunction remains unclear. Methods: We conducted a multicenter, open-label randomized trial comparing dual antiplatelet therapy (aspirin plus clopidogrel) in patients who had undergone successful...
Excessive uncontrolled airway narrowing is the main cause of symptoms in asthma, yet reasons behind this problem are still elusive. As mechanistic studies isolated airways from asthmatic individuals almost impossible to perform, aim study was investigate contractile responses intralobular bronchi (ILB) a guinea asthma model. These distal surrounded by parenchymal tissue and resemble functional characteristics human bronchi. Isolated ILB were mounted myographs measure smooth muscle reactions....
Background— Current monotherapy drug-eluting stents are associated with impaired healing, neoatherosclerosis, and late stent thrombosis. The healing profile neointimal transformation of the first dual-therapy endothelial progenitor cell–capturing sirolimus-eluting unknown. Methods Results— In this prospective, single-center study, 61 patients treated Combo had optical coherence tomography at baseline, early follow-up (4 monthly groups in a 1:2:2:1 ratio from 2 to 5 months), 9 months, 24...
There are at least 13 scoring systems for the assessment of disease severity in atopic dermatitis (AD). Each system has its problems with interobserver and intraobserver variability. Cutaneous T-cell attracting chemokine (CTACK) is a skin-specific chemoattractant which may correlate AD obviate issue observer reliability. We evaluated whether serum CTACK concentrations were associated children according to SCORing Atopic Dermatitis (SCORAD) index. Thirty-seven Chinese (23 boys, 14 girls; aged...
Atopic dermatitis (AD) is a distressing disease associated with pruritus and sleep disturbance. It not known how well these symptoms correlate the extent intensity of eczematous involvement. We evaluated whether: (i) level loss correlates (ii) or severity AD in children according to SCORing Dermatitis (SCORAD) index.Patients younger than 18 years old were recruited from pediatric dermatology clinic university teaching hospital, was by SCORAD index.One hundred eighty-two Chinese (107 boys 75...
The main aim of this study is to determine the pattern referrals poisoning a tertiary university hospital. information will be used for poison prevention programme planning, and educating awareness promoting public.All patients (under 21 years age) admitted paediatric wards between January 1997 December 2002 with discharge diagnosis indicating unintentional (UP) or intentional (IP) were identified through computerised information.Sixty males 98 females accounted 161 admissions over 6-year...
Objective The CYP2C19 loss-of-function (LoF) allele is present in half of the East Asian population and associated with high on-treatment platelet reactivity (HTPR). This study aimed to investigate whether a rapid genotyping-guided approach feasible efficacious for selecting P2Y12 receptor blockers Chinese patients suffering from acute coronary syndrome (ACS). Methods was single-centre, prospective, randomized, open-label study. A total 132 ACS were randomized treatment group (GG, N = 65) or...
This study aimed to establish the early healing and neointimal transformation profile of new polymer-free BioFreedom stent through sequential optical coherence tomography (OCT) within first nine months following implantation.We randomly assigned 104 BFS recipients one five groups with angiography OCT follow-up at 1, 2, 3, 4, or 5 months, together another for all months. The primary endpoint was degree OCT-detected strut coverage From median increased from 85.8, 87.0, 88.6, 96.8 97.1%,...
Leukotriene E4 (LTE(4)) is elevated in adults with atopic dermatitis (AD). We evaluated whether urinary LTE(4) as a noninvasive marker correlates clinical indices of disease activity children AD. AD patients aged 18 years or younger were eligible for inclusion the study. Disease severity over preceding 3 days was by SCORing Atopic Dermatitis (SCORAD) index. Severity past 12 months Nottingham Eczema Score (NESS) Chinese. Urinary concentration measured competitive enzyme immunoassay. One...
Pruritus and scratching are cardinal symptoms of atopic dermatitis (AD). Sleep growth may also be affected in children with moderate-to-severe AD. We evaluated whether resting energy expenditure (REE), oxygen consumption (VO2) carbon dioxide production (VCO2) various stages sleep were influenced by the disease severity.Disease severity was scoring (SCORAD) index. All-night polysomnography performed REE, VO2 VCO2 measured.Twenty (13 boys seven girls) AD eight controls recruited. The median...
Introduction Current international guidelines recommend non-vitamin K oral anticoagulants (NOACs) for stroke prevention among patients with non-valvular atrial fibrillation (AF) at significant ischaemic risk given the superior safety and comparable efficacy of NOACs over warfarin. Nonetheless, effectiveness have not been evaluated in AF underlying moderate or severe mitral stenosis (MS), hence recommended strategy remains warfarin therapy. Method analysis MS disproportionately prevalent...
Background— Durable polymers used in drug-eluting stents are considered a potential cause of hypersensitivity inflammatory response adversely affecting stent healing. Using sequential follow-up with optical coherence tomography, we compared the differences healing profiles 2 biodegradable or durable polymer. Methods and Results— Sixty patients multivessel disease were prospectively enrolled to receive both study stents, which randomly assigned individual vessels, Resolute Integrity...
Optimal antithrombotic strategy following transcatheter aortic valve replacement (TAVR) is still unknown. We hypothesised that the direct factor Xa inhibitor edoxaban can potentially prevent subclinical leaflet thrombosis and cerebral embolisation compared with conventional dual antiplatelet therapy (DAPT) in patients undergoing TAVR.The ADAPT-TAVR trial an international, multicentre, randomised, open-label, superiority comparing edoxaban-based DAPT without indication for oral...
The effect of subclinical leaflet thrombosis, characterised by hypoattenuated thickening (HALT), on the valve haemodynamic function and durability bioprosthetic valve, is not yet determined. We determined impact HALT haemodynamics after transcatheter aortic replacement (TAVR) predictors structural deterioration (SVD). Anticoagulation vs Dual Antiplatelet Therapy for Prevention Leaflet Thrombosis Cerebral Embolization Transcatheter Aortic Valve Replacement(ADAPT-TAVR) trial a multicenter,...
Background: The choice of oral therapeutic agents for the treatment atopic dermatitis (AD) in children is limited. Montelukast, a specific cysteinyl leukotriene (LT) receptor antagonist, may be useful alleviating AD symptoms. Objective: To evaluate clinical and immunological effects montelukast with AD. Methods: After 2‐week run‐in, were started on 5 mg once‐daily <12 years age 10 older children. severity as indicated by SCORing Atopic Dermatitis (SCORAD) score, serum soluble CD14 urinary E4...
Patients who survive myocardial infarction (MI) are at risk of recurrent cardiovascular (CV) events. This study stratified post-MI patients for CV events using the Thrombolysis in Myocardial Infarction (TIMI) Risk Score Secondary Prevention (TRS 2°P).