A5100411151- Ferroptosis and cancer prognosis
- interferon and immune responses
- Computational Drug Discovery Methods
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Neuroendocrine regulation and behavior
- Cancer, Lipids, and Metabolism
- Obesity, Physical Activity, Diet
- Pancreatic and Hepatic Oncology Research
- HER2/EGFR in Cancer Research
- Renin-Angiotensin System Studies
- Breast Lesions and Carcinomas
- Intracerebral and Subarachnoid Hemorrhage Research
- Cancer Immunotherapy and Biomarkers
- Birth, Development, and Health
- MicroRNA in disease regulation
- Breast Cancer Treatment Studies
- Economic and Financial Impacts of Cancer
- Pancreatitis Pathology and Treatment
- Glioma Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Food Security and Health in Diverse Populations
Soochow University
2009-2023
First Affiliated Hospital of Soochow University
2021-2023
Columbia University
2017-2023
Qingdao University
2016-2023
Chinese PLA General Hospital
2021-2023
Xiangya Hospital Central South University
2022
Central South University
2022
First Affiliated Hospital of Xi'an Jiaotong University
2022
Wuhan Third Hospital
2022
Tongren Hospital
2022
Abstract Response inhibition is crucial for mental and physical health but studies assessing the trainability of this type are rare. Thirty‐nine children aged 10‐12 years 46 adults 18‐24 were assigned to an adaptive go/no‐go training condition or active control condition. Transfer effects performance on tasks response inhibition, interference control, working memory updating, task‐switching, non‐verbal fluid intelligence assessed during 3‐ 6‐month follow‐up sessions and/or immediate...
Background Ferroptosis is involved in the drug resistance mechanisms of some tumors. The present study aimed to explore role tissue inhibitor matrix metalloprotease 1 (TIMP1) sorafenib-triggered ferroptosis colorectal cancer (CRC).Methods HCT-8 CRC cell lines were generated that sorafenib-resistant or under- overexpressed TIMP1. levels reactive oxygen species (ROS), iron, and malondialdehyde (MDA) compared across different lines. half-maximal inhibitory concentration sorafenib against was...
// Ling Chen 1, 2 , Guangming Kong 3 Chuantao Zhang 1 Hongyan Dong 4 Cuicui Yang Guanhua Song 5 Chengye Guo Lin Wang 6 Hongsheng Yu Department of Oncology, Affiliated Hospital Qingdao University, Qingdao, China Municipal Hospital, Emergency Department, Pathology, Linyi People's Linyi, Institute Basic Medicine, Shandong Academy Medical Sciences, Jinan, Research Center for Medicinal Biotechnology, Key Laboratory Rare and Uncommon Diseases Province, Correspondence to: Yu, e-mail:...
Background: Ferroptosis is a new form of cell death recently discovered that distinct from apoptosis, necrosis and autophagy. This article expected to provide direction for the treatment cardiomyopathy in future by screening potential drug targets associated with ferroptosis. Methods: Differential expression analysis GSE5406 Gene Expression Omnibus (GEO) database was performed using GEO2R tool. Functional annotation ferroptosis related genes also performed. Then we constructed...
Abstract Growth hormone secretagogue receptor 1a (GHS-R1a) is an important G protein-coupled (GPCR) that regulates a variety of functions by binding to ghrelin. It has been shown the dimerization GHS-R1a with other receptors also affects ingestion, energy metabolism, learning and memory. Dopamine type 2 (D R) GPCR mainly distributed in ventral tegmental area (VTA), substantia nigra (SN), striatum brain regions. In this study we investigated existence function GHS-R1a/D R heterodimers nigral...
Ischemia causes desquamation of proximal tubular epithelial cells leading to acute renal failure. However, the molecular mechanisms underlying detachment tubule remain unknown. In this study, we reported that ATP depletion resulted in actin polymerization, a shift filamentous from web-like structure fragmented parallel stress fibers, followed by reduction cellular adhesion ability. The pre-treatment with Jasplakinolide, an stabilizer, prevented depletion-induced polymerization and cell...
Objectives. To examine the relationship of parental sugar-sweetened beverage (SSB) attitudes with SSB consumption during first 1000 days life—gestation to age 2 years. Methods. We studied 394 Special Supplemental Nutrition Program for Women, Infants, and Children (WIC)–enrolled families life in northern Manhattan, New York, 2017. In regression models, we assessed cross-sectional relationships attitude scores habitual daily parent calories infant consumption, adjusting demographic...
We previously demonstrated that the combined exposure of human pulmonary microvascular endothelial cells (HPMECs) to morphine and viral protein(s) results in oxidative stress-mediated induction autophagy, leading shift from early apoptotic apoptosis-resistant proliferative status associated with angioproliferative remodeling observed arterial hypertension (PAH). In this study, we tried delineate major source HIV-1 protein Tat induced burst HPMECs its consequences on vascular PAH an vivo...
The present study aimed to investigate the expression levels of tumor necrosis factor-α-induced protein 8 (TNFAIP8) in gastric adenocarcinoma. TNFAIP8 adenocarcinoma tissue samples (with and without lymph node metastasis), adjacent normal metastatic were detected by immunohistochemistry. correlation between clinicopathological data prognosis was analyzed. results demonstrated that markedly increased at a rate 47.2% (50/106) 81.7% (49/60), respectively, as compared with which no TNGFAIP8...
The diagnosis of primary biliary cholangitis (PBC) in patients with seropositive anti-mitochondrial antibody (AMA) but normal alkaline phosphatase (ALP) depends on a liver biopsy. We aimed to reveal potential serum biomarkers that could suggest the necessity biopsy such patients. Retrospective analysis was performed. Subjects who were treatment naive AMA ALP and underwent at least one between 2008 2020 included this study. Histologic biopsies evaluated by two experienced pathologists blinded...
Introduction: Kidney renal clear cell carcinoma (KIRC), a kind of malignant disease, is severe threat to public health. Tracking the information tumor progression and conducting related dynamic prognosis model are necessary for KIRC. It crucial identify hypoxia-immune-related genes construct prognostic due immune interaction influence hypoxia in patients with Methods: The status KIRC were identified by utilizing t-SNE ImmuCellAI gene expression data. COX Lasso regression used some signature...
Growth arrest-specific 6 protein (Gas6) has been established to play important roles in various biological processes, but little is currently known on the role of Gas6 signaling humans. This research explored association between expression and carotid atherosclerosis (AS) type 2 diabetes mellitus (T2DM).As many as 126 T2DM patients were recruited this study classified into two groups based their intima-media thickness (CIMT). Meanwhile, 50 healthy individuals for normal control group (NC)....
Introduction Immune checkpoint inhibitor (ICI) therapy has been proven to be a highly efficacious treatment for colorectal adenocarcinoma (COAD). However, it is still unclear how identify those who might benefit the most from ICI therapy. Hypoxia facilitates progression of tumor different aspects, including proliferation, metabolism, angiogenesis, and migration, improves resistance ICI. Therefore, essential conduct comprehensive understanding influences hypoxia in COAD biomarker predicting...
Glioma is the most common malignant primary brain tumor and characterized by a poor prognosis limited therapeutic options. ISG20 expression induced interferons or double-stranded RNA associated with in several tumors. Nevertheless, of gliomas, its impact on patient prognosis, role immune microenvironment have not been fully elucidated.Using bioinformatics, we comprehensively illustrated potential function ISG20, predictive value stratifying clinical association immunological characteristics...
Patients who survive myocardial infarction (MI) are at risk of recurrent cardiovascular (CV) events. This study stratified post-MI patients for CV events using the Thrombolysis in Myocardial Infarction (TIMI) Risk Score Secondary Prevention (TRS 2°P).