A5064516205- Ferroptosis and cancer prognosis
- Neurological Disease Mechanisms and Treatments
- Neonatal and fetal brain pathology
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- Neonatal Respiratory Health Research
- Lanthanide and Transition Metal Complexes
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Electron Spin Resonance Studies
- Neuroscience of respiration and sleep
- Inflammasome and immune disorders
- Analytical Chemistry and Sensors
- Bone and Dental Protein Studies
- Renal cell carcinoma treatment
- Pancreatic and Hepatic Oncology Research
- Advanced MRI Techniques and Applications
- Electrochemical sensors and biosensors
- Hepatocellular Carcinoma Treatment and Prognosis
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Retinal Imaging and Analysis
First Affiliated Hospital of Xi'an Jiaotong University
2021-2023
Weifang Medical University
2018-2020
Wuhan University
2006
Abstract The voltammetric behavior of uric acid (UA) has been studied at a multiwalled carbon nanotube‐ionic liquid (i.e., 1‐butyl‐3‐methylimidazolium hexafluorophosphate, BMIMPF 6 ) paste coated glassy electrode (MWNTs‐BMIMPF /GC). It is found that UA can effectively accumulate this and cause sensitive anodic peak about 0.49 V (vs. SCE) in pH 4.0 phosphate buffer solutions. Experimental parameters influencing the response electrode, such as solution accumulation time, are optimized for...
This study aims to observe the effects of transplantation umbilical cord blood mononuclear cells (UCBMCs) on expression interleukin (IL)-1β and explore mechanism via toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) pathway in hypoxic-ischemic neonatal rats. Seven-day-old Sprague-Dawley rats were randomly divided into Sham, brain damage (HIBD), UCBMC groups. The HIBD model was prepared by Rice-Vannucci method, transplanted 24 h after group. At 7 days transplantation, changes neurons...
Introduction: Kidney renal clear cell carcinoma (KIRC), a kind of malignant disease, is severe threat to public health. Tracking the information tumor progression and conducting related dynamic prognosis model are necessary for KIRC. It crucial identify hypoxia-immune-related genes construct prognostic due immune interaction influence hypoxia in patients with Methods: The status KIRC were identified by utilizing t-SNE ImmuCellAI gene expression data. COX Lasso regression used some signature...
Introduction Immune checkpoint inhibitor (ICI) therapy has been proven to be a highly efficacious treatment for colorectal adenocarcinoma (COAD). However, it is still unclear how identify those who might benefit the most from ICI therapy. Hypoxia facilitates progression of tumor different aspects, including proliferation, metabolism, angiogenesis, and migration, improves resistance ICI. Therefore, essential conduct comprehensive understanding influences hypoxia in COAD biomarker predicting...
Secreted protein, acidic and rich in cysteine (SPARC) has been characterized as an oncoprotein esophageal squamous cell carcinoma (ESCC), but its involvement the pathological development of adenocarcinoma (ESAD) remains poorly understood. In this study, we aimed to explore sources SPARC tumor microenvironment (TME) functional role ESAD. Bioinformatic analysis was conducted using data from The Cancer Genome Atlas (TCGA)-esophageal cancer (ESCA) Genotype-Tissue Expression (GTEx). ESAD line...
Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) had shown potential in sensing pH changes that occurs early ischemic stroke. However, detection of mild acidosis is still challenging. To enhance CEST for ischemia, we proposed a quantification approach using the residual inversed Z-spectra, i.e. MTR <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Rex</sub> <sup xmlns:xlink="http://www.w3.org/1999/xlink">VOPVP</sup> =...
Objective To explore the effects of two routes melatonin (MT) administration including intraperitoneal and caudal vein injection on behavior, histopathology expression myelin basic protein (MBP) active caspase-3 in focal cerebral ischemic rats. Methods 84 male Sprangue-Dawley rats were randomly divided into normal control group(CON, n=12), middle artery occlusion group(MCAO, n=24), MT-intraperitoneal group (n=24) MT-intravenous by random number table. Twenty-four hours after ischemia...
Abstract Background Gastric carcinoma still threatens public health with high morbidity and mortality, especially in Eastern Asia. Target therapy possesses a vast value makes significant progress cancer treatment, it is essential to explore more potential target drugs gastric carcinoma. Methods Gene expression data was obtained from TCGA (The Cancer Genome Atlas) GEO (Gene Expression Omnibus) datasets the interaction networks of chemical-genes CTD (Comparative Toxicogenomics Database). Then,...
We evaluated the prognostic value of m6A-related long noncoding RNAs (lncRNAs) in lung adenocarcinoma (LUAD).The expression levels lncRNAs and mRNAs LUAD normal adjacent tissues from The Cancer Genome Atlas dataset were analyzed using limma package. m6A enzyme-related differentially expressed identified used to construct a regulatory network. Survival analysis was performed correlation between lncRNAs, regulators, analyzed; followed by functional enrichment analysis.A comparison samples...
Objective To investigate the effects of melatonin on proliferation neural stem cells (NSCs) in cerebral ischemia reperfusion (IR) rats, and to explore possible mechanisms. Methods Seventy-two rats were randomly divided into normal control group (n=12), model (n=30) according random number table. The four subgroups: 6 h, 24 72 h 7 d subgroups time after IR. morphological changes subventricular zone (SVZ) examined by HE staining; NSCs immunofluorescence toll-like receptor 4 (TLR4)...
Objective To observe the effect of melatonin (MT) on retinal apoptosis in rats with ischemia-reperfusion injury (RIRI). Methods A total 54 male healthy Sprague-Dawley adult were randomly divided into normal control (CON) group (6 rats), RIRI (24 rats) and MT rats). The induced using suture-occluded methods to establish model. injected left carotid artery 30 minutes after RIRI, was same amount saline. On 6, 24 hours 3, 7 days morphological changes retina evaluated by hematoxylin eosin...
Abstract Cervical squamous cell carcinoma and endocervical adenocarcinoma(CESC) is one of the more common tumors in women worldwide has a higher mortality rate. However, there paucity information about specific biomarkers that assist diagnosis prognosis CESC. The development prognostic model important if we are to improve treatment strategies. Pyroptosis form programmed death, its different elements related occurrence, invasion metastasis tumors. role pyroptosis CESC progression not been...
Objective: To compare the effects of 2 techniques semi-hepatic alternating radiotherapy on diffuse hepatic metastasis in patients with breast cancer. Methodology: A total 68 cancer liver were randomly divided into Group (semi-hepatic radiotherapy) and B sequential radiotherapy). In radiotherapy), was first semi-liver second alternatively treated intensity-modulated radiation therapy (IMRT). The interval between instances 6 h. average dose to semi-livers both Gy/fraction, once a day, 5 times...