A5005326788- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Angiogenesis and VEGF in Cancer
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Neuroblastoma Research and Treatments
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatitis Pathology and Treatment
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Lymphoma Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- Estrogen and related hormone effects
- Inflammatory mediators and NSAID effects
- Autoimmune and Inflammatory Disorders Research
First Affiliated Hospital of Xi'an Jiaotong University
2013-2025
Hangzhou Medical College
2024
First Affiliated Hospital of GuangXi Medical University
2021-2024
Guangxi Medical University
2021-2024
Xi'an Jiaotong University
2017-2023
Weatherford College
2022
Xi'an Medical University
2020
Clear cell renal carcinoma (ccRCC) is the most representative subtype of cancer. CircRNA acts as a kind ceRNA to play role in regulating microRNA (miRNA) many cancers. However, potential pathogenesis regulatory network among circRNA/miRNA/mRNA not clear and has been fully explored. expression profile data were obtained from GEO datasets, differentially expressed circRNAs (DECs) identified through utilizing R package (Limma) firstly. Secondly, miRNAs that regulated by these predicted using...
Pancreatic ductal adenocarcinoma (PDAC) is frequently diagnosed and treated in advanced tumor stages with poor prognosis. More effective screening programs novel therapeutic means are urgently needed. Recent studies have regarded tight junction protein claudin 18.2 (CLDN18.2) as a candidate target for cancer treatment, zolbetuximab (formerly known IMAB362) has been developed against CLDN18.2. However, there few data reported thus far related to the clinicopathological characteristics of...
The present study aimed to investigate the clinicopathological significance of programmed cell death ligand-1 (PD-L1) and protein 1 (PD-1) expression in extrahepatic cholangiocarcinoma (ECC). PD-L1 PD-1 was detected by immunohistochemical methods 70 ECC formalin-fixed, paraffin-embedded tissue specimens 50 para-carcinoma specimens. associations with characteristics prognosis patients were explored. Positive rates increased tissues compared those corresponding tissues. Besides, correlated...
Programmed death 1 (PD-1) receptor and its ligand, programmed ligand-1 (PD-L1), play critical roles in the immune invasion of various tumors. This study aimed to explore clinical significance PD-L1/PD-1 expression progression pulmonary neuroendocrine tumors (PNETs).The PD-L1 PD-1 80 patients diagnosed with PNETs were investigated. Immunohistochemical analysis was performed on formalin-fixed paraffin-embedded tissue specimens from 20 corresponding cancer-adjacent specimens.Tissues had higher...
Abstract Background Cancer-associated fibroblasts (CAFs), the primary component of tumor stroma in microenvironments, are well-known contributors to malignant progression gallbladder cancer (GBC). Thrombospondins (THBSs or TSPs) comprise a family five adhesive glycoproteins that overexpressed many types cancers. However, expression and potential roles TSPs crosstalk between CAFs GBC cells has remained unclear. Methods Peritumoral (PTFs) were extracted from tissues. Thrombospondin was...
657 Background: Currently, there is limited exploration regarding the treatment of NET G3, resulting in restricted options. Therapeutics for G1/2 may serve as an alternative. Surufatinib, with its potent targeting VEGFRs, FGFR1, and CSF-1R, not only exerts inhibitory effects on tumor angiogenesis but also modulates immune microenvironment. Due to demonstrated efficacy manageable safety profile, it has secured approval NETs. Methods: This a multi-center real-world study that retrospectively...
Background Liver ischemia-reperfusion injury (LIRI) is a critical condition after liver transplantation. Understanding the role of immunogenic cell death (ICD) may provide insights into its diagnosis and potential therapeutic targets. Methods Differentially expressed genes (DEGs) between LIRI normal samples were identified, pathway enrichment analyses performed, followed by immune infiltration assessment through CIBERSORT method. The consensus clustering analysis was conducted to separate...
Abstract Background: Prognosis of NET G3 patients is usually poor and there currently no standard treatment. Preliminary studies have suggested antiangiogenic TKIs could improve PFS for these patients. This study aims to evaluate the efficacy surufatinib in advanced via Cox regression analysis identify predictive factors. Methods: A national multi-center was carried who were treated with surufatinib. primary endpoint. Logistic proportional-hazards models used assess factors PFS. The...
Ovarian cancer (OC) is highly prevalent and associated with high mortality rates due to metastasis relapse. In this study, we assessed the role of long non-coding RNA (lncRNA) small nucleolar host gene 1 (SNHG1) in OC gain further insight into mechanisms that contribute its aggressiveness. We analyzed correlation between SNHG1, miR-454 zinc finger E-box-binding homeobox (ZEB1) using a dual-luciferase reporter assay. Alterations cell invasiveness were observed wound-healing Transwell invasion...
Background: Previous studies have shown that cellular senescence is strongly associated with tumorigenesis and the tumor microenvironment.Accordingly, we developed a novel prognostic signature for intrahepatic cholangiocarcinoma (ICCA) based on senescence-associated long non-coding RNAs (SR-lncRNAs) identified lncRNA-miRNA-mRNA axis involving in ICCA.Methods: Based 197 genes (SRGs) from Genacards their expression Fu-ICCA cohort, 20 lncRNAs as through co-expression cox-regression...
// Ke Ma 1, * , Yangwei Fan Xuyuan Dong 1 Danfeng Yuyan Guo 2 Xin Wei 3 Jing Ning 4 Qianqian Geng 5 Chuying Wang Yuan Hu Mengya Li Wenxia Niu Enxiao and Yinying Wu Department of Medical Oncology, The First Affiliated Hospital Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China Radiation Province People's Hospital, 710068, Obstetrics Gynecology, Third Nuclear Medicine, These authors have contributed equally to this work Correspondence to: Wu, email: shadowless_111@163.com...
Long non-coding RNAs (lncRNAs) are key regulators or a range of diseases and chronic conditions such as cancers, but how they function in the context ovarian cancer (OC) is poorly understood. The Coding-Potential Assessment Tool was used to assess likely protein-coding potential SNHG7. SNHG7 expression elevated tumour tissues measured by qRT-PCR. online database JASPAR predict transcription factors binding Twenty-four-well Transwell plates were for invasion assays. RNA immunoprecipitation...
Abstract There is a lack of effective programmed cell death protein 1 (PD-1)‐targeted immunotherapy with good tolerability in patients advanced hepatocellular carcinoma (HCC) and severely compromised liver function. We assessed patient outcomes after combined camrelizumab molecular targeted therapy multicenter cohort study China. The included 99 HCC (58 Child-Pugh A 41 B), 84 them received from January 10, 2019, to March 31, 2021. Overall survival (OS), progression-free (PFS), objective...
We aimed to develop a nomogram predict the survival and prognosis of adenosquamous carcinoma pancreas (ASCP).
Abstract High rates of de novo lipid synthesis have been discovered in certain kinds tumours, including gallbladder cancer (GBC). Unlike several other GBC is highly insensitive to standard adjuvant therapy, which makes its treatment even more challenging. Although potential targets and signalling pathways underlying chemoresistance revealed, the precise mechanisms are still elusive. In this study, we found that α‐Mangostin, as a dietary xanthone, repressed proliferation clone formation...
Medication combination prediction can be applied to the clinical treatment for critical patients with multi-morbidity. The suitable medication help cure and keep safe. However, complexity uncertainty of circumstances limit predictive accuracy combination. Thus, this paper proposes a new model based on temporal attention mechanism (TAM) simple graph convolution (SGC), named as TAMSGC. More specifically, TAM capture sequence information in medical records, SGC is implemented acquire knowledge...
The site-distribution pattern and relative risk of subsequent primary malignancies (SPMs) in colorectal cancer (CRC) patients remains to be determined.A population-based cohort 288,390 CRC diagnosed between 1973 2012 from the Surveillance, Epidemiology, End Results database was retrospectively reviewed. Standardized incidence ratios were calculated estimate for SPMs.The overall SPMs increased (standardized ratio 1.02) first 5 years after diagnosis compared with that general population,...
A rapid and sensitive method for determining aesculin of Cortex fraxini in rat was developed using high-performance liquid chromatography (HPLC) quadrupole time-of-flight (QTOF) tandem mass (MS/MS). Rat plasma pretreated by fourfold methanol to remove proteins. Chromatographic separation performed on a reverse phase column. spectrometric detection with an electrospray ionization (ESI) interface achieved collision-induced dissociation (CID) under positive mode. The MS/MS patterns monitored...
Background: Kidney renal clear cell carcinoma (KIRC) is the most representative subtype of cancer.Immune infiltration was associated with survival time patients tumors.C-C chemokine ligand 5 (CCL5) can promote malignant process tumor and be related to immune cells in some cancers, but not reported KIRC.Methods: The expression profile clinical data were obtained from Cancer Genome Atlas (TCGA) database.The correlation between level CCL5 features KIRC analyzed.Gene Set Enrichment Analysis...
Pancreatic cancer is generally characterized with high levels of malignancy and poor prognosis. In addition, there are currently no effective therapeutic agents against the disease. However, apatinib which a small molecular agent targeting vascular endothelial growth factor receptor 2 (VEGFR-2), has been shown to generate favorable outcomes in gastric cancer. Therefore, present study explored effects on pancreatic cancer.The activity ASPC-1 or PANC-1 cells was examined through colony...
Adenosquamous carcinoma of the pancreas (ASCP) is a rare histological subtype pancreatic cancer with poor prognosis and high metastasis rate. However, little known about its genomic landscape prognostic biomarkers. A total 48 ASCP specimens 98 ductal adenocarcinoma (PDAC) tumour were sequenced to explore The homozygous deletion 9p21.3 region (including CDKN2A, CDKN2B, MTAP) (9p21 loss) occurred in both PDAC, higher frequency 9p21 loss was observed (12.5% vs 2.0%, P = 0.022). Notably,...