A5024334309- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Angiogenesis and VEGF in Cancer
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Cancer, Lipids, and Metabolism
- Cancer Treatment and Pharmacology
- Ubiquitin and proteasome pathways
- Genetic factors in colorectal cancer
- Histone Deacetylase Inhibitors Research
- Gastric Cancer Management and Outcomes
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Renal cell carcinoma treatment
- Advanced Breast Cancer Therapies
- Cancer-related gene regulation
- Glioma Diagnosis and Treatment
- Microtubule and mitosis dynamics
- RNA modifications and cancer
First Affiliated Hospital of Xi'an Jiaotong University
2015-2024
Xi'an Jiaotong University
2020
Programmed death 1 (PD-1) receptor and its ligand, programmed ligand-1 (PD-L1), play critical roles in the immune invasion of various tumors. This study aimed to explore clinical significance PD-L1/PD-1 expression progression pulmonary neuroendocrine tumors (PNETs).The PD-L1 PD-1 80 patients diagnosed with PNETs were investigated. Immunohistochemical analysis was performed on formalin-fixed paraffin-embedded tissue specimens from 20 corresponding cancer-adjacent specimens.Tissues had higher...
Abstract Background Cancer-associated fibroblasts (CAFs), the primary component of tumor stroma in microenvironments, are well-known contributors to malignant progression gallbladder cancer (GBC). Thrombospondins (THBSs or TSPs) comprise a family five adhesive glycoproteins that overexpressed many types cancers. However, expression and potential roles TSPs crosstalk between CAFs GBC cells has remained unclear. Methods Peritumoral (PTFs) were extracted from tissues. Thrombospondin was...
HOXD10, a key regulator of cell-differentiated phenotype maintainence, has been demonstrated to be involved in the tumorigenesis many human malignacies. However, status HOXD10 expression and its biological function cholangiocellular carcinoma (CCC) remain clarified. In present study, we investigated clinical significance functions CCC found that downstream effector RHOC was significantly different well-differentiated tissues compared with poorly-differentiated lesions. We also observed...
Background: Previous studies have shown that cellular senescence is strongly associated with tumorigenesis and the tumor microenvironment.Accordingly, we developed a novel prognostic signature for intrahepatic cholangiocarcinoma (ICCA) based on senescence-associated long non-coding RNAs (SR-lncRNAs) identified lncRNA-miRNA-mRNA axis involving in ICCA.Methods: Based 197 genes (SRGs) from Genacards their expression Fu-ICCA cohort, 20 lncRNAs as through co-expression cox-regression...
Triple-negative breast cancer (TNBC) has a poor prognosis mainly due to insensitivity or resistance standard anthracycline- and taxane-based chemotherapy, urgently calling for new adjuvants reverse drug resistance. Dual-target murine double minute 2 (MDM2) X (MDMX) inhibitor been proved play critical part against cancer, particularly focusing on the tremendous potential enhance efficacy of doxorubicin (DOX), however little was reported in TNBC. In present study, we investigated synergistic...
Ras homolog family member C (RHOC) is important during the progression of several types cancer, including prostate, breast and hepatocellular carcinoma. However, function RHOC in cholangiocellular carcinoma (CCC), a highly recurrent metastatic with poor prognosis, remains unclear. The aim present study was to investigate involvement CCC tumor progression. expression levels were examined tissues cells, adjacent nontumorous bile duct tissues. effects molecular mechanisms on cell migration...
// Ke Ma 1, * , Yangwei Fan Xuyuan Dong 1 Danfeng Yuyan Guo 2 Xin Wei 3 Jing Ning 4 Qianqian Geng 5 Chuying Wang Yuan Hu Mengya Li Wenxia Niu Enxiao and Yinying Wu Department of Medical Oncology, The First Affiliated Hospital Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China Radiation Province People's Hospital, 710068, Obstetrics Gynecology, Third Nuclear Medicine, These authors have contributed equally to this work Correspondence to: Wu, email: shadowless_111@163.com...
Abstract There is a lack of effective programmed cell death protein 1 (PD-1)‐targeted immunotherapy with good tolerability in patients advanced hepatocellular carcinoma (HCC) and severely compromised liver function. We assessed patient outcomes after combined camrelizumab molecular targeted therapy multicenter cohort study China. The included 99 HCC (58 Child-Pugh A 41 B), 84 them received from January 10, 2019, to March 31, 2021. Overall survival (OS), progression-free (PFS), objective...
Abstract High rates of de novo lipid synthesis have been discovered in certain kinds tumours, including gallbladder cancer (GBC). Unlike several other GBC is highly insensitive to standard adjuvant therapy, which makes its treatment even more challenging. Although potential targets and signalling pathways underlying chemoresistance revealed, the precise mechanisms are still elusive. In this study, we found that α‐Mangostin, as a dietary xanthone, repressed proliferation clone formation...
Chemotherapy resistance represents a major obstacle for the treatment of patients with breast cancer (BC) and greatly restricts therapeutic effect first-line chemotherapeutic agent doxorubicin (DOX). The present study aimed to investigate feasibility recombinant dual-target murine double minute 2 (MDM2) X (MDMX) inhibitor in reversing DOX BC. Both DOX-resistant human carcinoma cell lines exhibited multidrug (MDR) phenotype. ability MDM2/MDMX was subsequently verified, (9.15 13.92 - fold...
Pancreatic cancer is generally characterized with high levels of malignancy and poor prognosis. In addition, there are currently no effective therapeutic agents against the disease. However, apatinib which a small molecular agent targeting vascular endothelial growth factor receptor 2 (VEGFR-2), has been shown to generate favorable outcomes in gastric cancer. Therefore, present study explored effects on pancreatic cancer.The activity ASPC-1 or PANC-1 cells was examined through colony...
Background: The evidence base for optimum third-line therapy metastatic colorectal cancer (mCRC) is not conclusive. Recent studies have demonstrated the efficacy of regorafenib as in mCRC. This indirect meta-analysis compared and safety with other available therapies Methods: A literature search randomized controlled trials (RCTs) was conducted PubMed, Embase, Cochrane Library evaluating fruquintinib, regorafenib, TAS-102, nintedanib patients Overall survival (OS) progression-free (PFS) were...
A novel molecular classification of gastric cancer by the Asian Cancer Research Group (ACRG) is a potential advance in diagnosis and treatment, it helps to determine prognosis. The use immunohistochemistry (IHC) rather than gene expression analysis tumor subtypes was evaluated with aim determining feasibility using ACRG classification. total 69 esophagogastric junction (EGJ) carcinomas were classified as microsatellite instable (MSI, 17.40%, 12 69), stable markers epithelial-to-mesenchymal...
e16316 Background: Advanced pancreatic ductal adenocarcinoma is a malignant tumor with poor prognosis. At present, chemotherapy still the standard treatment, however efficacy unsatisfied. The lack of second-line treatment options for cancer results in progression-free survival often lasting less than 3 months. For an immune desert type tumor, immunotherapy has not brought breakthrough therapeutic regimen compared to remarkable data other tumors.There insufficient evidence treated PD1...
Ras protein activator like 2 (RASAL2) has a cancer-related function, but plays inconsistent roles in different malignancies. This project was designed to determine the role of RASAL2 carcinogenesis gastric cancer. The Cancer Genome Atlas data revealed high levels cancer tissue, which confirmed clinical specimens via real-time quantitative PCR and western blotting assays. High correlated with reduced survival rate patients. In cell lines, silencing restrained cellular proliferation, invasion...
119 Background: The evidence base for optimum third-line therapy metastatic colorectal cancer (mCRC) is not conclusive. Recent studies have demonstrated the efficacy of regorafenib as in mCRC. This indirect meta-analysis compared and safety comparison to other available therapies Methods: Literature search randomized controlled trials was conducted PubMed, Embase Cochrane library evaluating fruquintinib, regorafenib, TAS-102 nintedanib mCRC patients. primary outcomes included overall...
e16271 Background: Existing treatment options including gemcitabine-based therapy and 5FU-based chemotherapy have limited prognostic impact in advanced pancreatic cancer (APC): the median overall survival (mOS) was 6-11 months for 1 st line 4-9 2 nd therapy. Nimotuzumab (nimo), anti-EGFR monoclonal antibody, had been shown to be more effective against APC two previous studies, PCS07 (a phase II study Germany) NOTABLE III China). Although obtained an encouraging result China, it focused on a...
Abstract Purpose : The electronic patient-reported outcome (ePRO) system plays an important role in routine cancer treatment, but information on its use to assess and monitor symptoms quality of life (QoL) advanced gastrointestinal patients China is limited. Methods Sixty with at the First Affiliated Hospital Xi'an Jiaotong University were enrolled. They completed ePRO questionnaires a computer provide nutrition, appetite, psychology, QoL data beginning treatment. nurses followed up...