A5100355091- Neonatal Respiratory Health Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cystic Fibrosis Research Advances
- Pulmonary Hypertension Research and Treatments
- Inhalation and Respiratory Drug Delivery
- Tracheal and airway disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Pediatric Hepatobiliary Diseases and Treatments
- Renal and related cancers
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Vascular Malformations Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Colorectal Cancer Treatments and Studies
- Occupational and environmental lung diseases
- Pneumonia and Respiratory Infections
- Intracranial Aneurysms: Treatment and Complications
- Cancer Treatment and Pharmacology
- Intracerebral and Subarachnoid Hemorrhage Research
- Congenital Diaphragmatic Hernia Studies
- Asthma and respiratory diseases
- Macrophage Migration Inhibitory Factor
- Cardiovascular and Diving-Related Complications
- Dental Trauma and Treatments
University of Iowa
2011-2024
Xinxiang Medical University
2014-2024
Shengli Oilfield Central Hospital
2024
First Affiliated Hospital of Xi'an Jiaotong University
2024
Hunan Academy of Agricultural Sciences
2024
Michigan State University
2004-2023
Second Affiliated Hospital of Xi'an Jiaotong University
2015-2023
Xinjiang Medical University
2018-2023
Michigan United
2023
First Affiliated Hospital of Xinjiang Medical University
2018-2023
Laminins and their integrin receptors are implicated in epithelial cell differentiation progenitor maintenance. We report here that a previously unrecognized subpopulation of mouse alveolar cells (AECs) expressing the laminin receptor α6β4, but little or no pro-surfactant C (pro-SPC), is endowed with regenerative potential. Ex vivo, this expanded clonally as progenitors also differentiated toward mature types. Integrin β4 itself was not required for AEC proliferation differentiation. An vivo...
Objective: Long-term treatment with nondepolarizing neuromuscular blocking agents and corticosteroids in the intensive care unit is not benign, an increasing number of patients acute quadriplegic myopathy have been reported increased use these drugs. The purpose this study was to investigate mechanisms underlying myopathy. Design: Percutaneous muscle biopsy samples were obtained, electrophysiologic examinations performed during phase recovery Regulation contraction myofibrillar protein...
Earlier work from this laboratory showed that local generation of angiotensin (ANG) II is required for the pathogenesis experimental pulmonary fibrosis and ANG peptides are expressed robustly in lungs patients with idiopathic (IPF). Angiotensin converting enzyme-2 (ACE-2) degrades octapeptide to form heptapeptide ANG1-7 thereby limits accumulation. On basis, we hypothesized ACE-2 would be protective against lung fibrogenesis might downregulated human fibrosis. In biopsy specimens IPF, mRNA...
BackgroundAortic dissection is a severe inflammatory vascular disease with high mortality and limited therapeutic options. The hallmarks of aortic comprise cell infiltration elastic fiber disruption, highlighting the involvement macrophage. Here role for macrophage hypoxia-inducible factor 1-alpha (HIF-1α) in was uncovered.MethodsImmunochemistry, immunofluorescence, western blot qPCR were performed to test change HIF-1α two kinds models human tissues. Metabolomics Seahorse extracellular flux...
Lapatinib (LAP) is an important anti-cancer drug and frequently alongside doxorubicin (DOX) as a combination therapy for better efficacy. However, many studies have reported that LAP in with DOX may induce highly cardiotoxicity. Accordingly, we aimed to explore the potential mechanism involved synergistic effect of DOX-induced Here, cell counting kit-8 was used detect viability lactate dehydrogenase measurement performed assess injury. Cell apoptosis evaluated by TUNEL assay western blot...
We recently identified epigallocatechin gallate (EGCG), a trihydroxyphenolic compound, as dual inhibitor of lysyl oxidase-like2 and transforming growth factor-β1 (TGFβ1) receptor kinase that when given orally to patients with idiopathic pulmonary fibrosis (IPF) reversed profibrotic biomarkers in their diagnostic biopsies. Here, we extend these findings advanced using cultured precision-cut lung slices from explants IPF undergoing transplantation. During experiments, were surprised discover...
While pathological and clinical data suggest that small airways are involved in early cystic fibrosis (CF) lung disease development, little is known about how the lack of transmembrane conductance regulator (CFTR) function contributes to pathogenesis these airways. Large airway epithelia exposed different airflow velocities, temperatures, humidity, CO 2 concentrations. The cellular composition two regions different, submucosal glands. To better understand ion transport properties impacts...
Previous work from this laboratory demonstrated de novo synthesis of angiotensin (ANG) peptides by apoptotic pulmonary alveolar epithelial cells (AEC) and lung myofibroblasts in vitro bleomycin-treated rats. To determine whether these same cell types also synthesize ANG within the fibrotic human situ, we subjected paraffin sections normal (idiopathic fibrosis, IPF) to immunohistochemistry (IHC) situ hybridization detect angiotensinogen (AGT) mRNA. These were analyzed both alone combination...
Idiopathic pulmonary fibrosis (IPF) is a pathological condition of unknown etiology that results from injury to the lung and an ensuing fibrotic response leads thickening alveolar walls obliteration space. The pathogenesis not clear, there are currently no effective therapies for IPF. Small airway disease mucus accumulation prominent features in IPF lungs, similar cystic disease.
To access the distinct values of contrast transcranial Doppler (cTCD), transthoracic echocardiography (cTTE), and transesophageal (cTEE) in diagnosis right-to-left shunt (RLS) due to patent foramen ovale (PFO) define most practical strategy for PFO.102 patients with a high clinical suspicion PFO had simultaneous cTCD, cTTE, cTEE performed. The agitated saline mixed blood was used detect (RLS).In all 102 patients, detected at rest by cTCD 60.78% cases, cTTE 42.16%, 47.06%. positive results 3...
Lack of CFTR (cystic fibrosis transmembrane conductance regulator) affects the transcriptome, composition, and function large small airway epithelia in people with advanced cystic (CF); however, whether lack causes cell-intrinsic abnormalities present at birth versus inflammation-dependent is unclear. We performed a single-cell RNA-sequencing census microdissected airways from newborn CF pigs, which recapitulate host defense defects pathology over time. minimally affected transcriptome...
A balance between alveolar liquid absorption and secretion is critical for maintaining optimal subphase height facilitating gas exchange in the space. However, role of cystic fibrosis transmembrane regulator protein (CFTR) this homeostatic process has remained elusive. Using a newly developed porcine model fibrosis, which CFTR absent, we investigated ion transport properties isolated type II epithelial cells (T2AECs) cultured at air-liquid interface. was distributed exclusively to apical...
Abstract There is a lack of effective programmed cell death protein 1 (PD-1)‐targeted immunotherapy with good tolerability in patients advanced hepatocellular carcinoma (HCC) and severely compromised liver function. We assessed patient outcomes after combined camrelizumab molecular targeted therapy multicenter cohort study China. The included 99 HCC (58 Child-Pugh A 41 B), 84 them received from January 10, 2019, to March 31, 2021. Overall survival (OS), progression-free (PFS), objective...
Apoptosis of alveolar epithelial cells (AECs) is believed to be critical for the development bleomycin (BLEO)-induced pulmonary fibrosis. Previous studies showed that apoptosis in response BLEO could abrogated by antisense oligonucleotides against angiotensinogen (AGT) mRNA and requires angiotensin II (ANG II) synthesis de novo [17]. In this study we hypothesized blockade local ANG intratracheal (I.T.) administration AGT might attenuate BLEO-induced AECs prevent a rat model lung fibrosis,...
To develop stem/progenitor cell-based therapy for cystic fibrosis (CF) lung disease, it is first necessary to identify markers of human epithelial progenitor/stem cells and better understand the potential differentiation into distinct lineages. Here we investigated integrin α6β4 as an progenitor cell marker in distal lung. We identified a subpopulation α6β4+ that localized small airways alveolar walls were devoid pro-surfactant protein C expression. The demonstrated key properties stem ex...
In a newborn pig cystic fibrosis (CF) model, the ability of gland-containing airways to fight infection was affected by at least two major host-defense defects: impaired mucociliary transport and lower airway surface liquid (ASL) pH. airways, ASL pH is balanced CFTR (CF transmembrane conductance regulator) ATP12A, which, respectively, control HCO3- proton secretion. We found that, although porcine small tissue expressed amounts epithelial cultures from CF distal (diameter < 200 μm) were...
We investigated the allelic frequencies and forensic descriptive parameters of 23 autosomal short tandem repeat loci in a randomly selected sample 1218 unrelated healthy Uyghur individuals residing Xinjiang Autonomous Region, northwest China. A total 281 alleles at these were identified their corresponding ranged from 0.0004 to 0.5390. The combined match probability exclusion all 5.192 × 10-29 0.9999999996594, respectively. results population genetic study manifested that had close...
IL-18 polymorphisms influence the transcriptional activity of gene and associated with various diseases. However, their relationships hepatitis B virus-related liver diseases had not reached a consensus. So we conducted this case-control study view to clarifying association. We included four groups: healthy controls, chronic virus (CHB) carriers, cirrhosis (LC) hepatocellular carcinoma (HCC) groups each group 250 persons. Odd ratios (ORs) 95% confidence intervals (95%CIs) or without...
Chemotherapy-related hepatotoxicity is a limitation for the continuation of chemotherapy in patients with advanced colorectal cancer (CRC). This prospective study determined efficacy tiopronin infusion chemotherapy-induced hepatoxicity.One hundred and fifty having CRC treated first-line palliative were included, whom 86 mFOLFOX7 plus supplementation 64 same regimen without tiopronin. Aspartate aminotransferase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), total bilirubin...
Insufficient milk supply is a widespread issue faced by women globally and associated with higher risk of health problems in infants mothers. Hemerocallis citrina Baron, commonly known as daylily, perennial edible plant often used traditional Asian cuisine to promote lactation. However, the active compound(s) mechanism its lactation-promoting effect remain unclear. This study aimed confirm use daylily promoting lactation investigate potential components underlying molecular mechanisms. Our...