A5077972205- Lysosomal Storage Disorders Research
- Rock Mechanics and Modeling
- Neuroscience and Neuropharmacology Research
- Hydraulic Fracturing and Reservoir Analysis
- Mitochondrial Function and Pathology
- Olfactory and Sensory Function Studies
- Drilling and Well Engineering
- Adenosine and Purinergic Signaling
- Hydrocarbon exploration and reservoir analysis
- Seismic Imaging and Inversion Techniques
- Ion Transport and Channel Regulation
- GaN-based semiconductor devices and materials
- Ga2O3 and related materials
- Calcium signaling and nucleotide metabolism
- Birth, Development, and Health
- ATP Synthase and ATPases Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Photocathodes and Microchannel Plates
- Prion Diseases and Protein Misfolding
- Fluid Dynamics and Turbulent Flows
- Medical Image Segmentation Techniques
- Neuropeptides and Animal Physiology
- Photoreceptor and optogenetics research
- Geotechnical Engineering and Soil Mechanics
- Aerodynamics and Acoustics in Jet Flows
Xinxiang Medical University
2019-2024
Henan Psychiatric Hospital
2024
Hebei University of Technology
2023-2024
Beihang University
2024
China University of Petroleum, East China
2021-2023
Tongji University
2020
Kōchi University
2016-2017
Shandong University
2014
Kochi Medical School Hospital
2009
Shenyang Pharmaceutical University
2009
In this work, AlGaN-based deep ultraviolet micro-light-emitting diode (DUV <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\mu $ </tex-math></inline-formula> LED) with a thin p-GaN layer is proposed to improve the electrical and optical performances. The experimental calculated results prove that, besides significantly enhanced light extraction efficiency (LEE) caused by reduced absorption for DUV light,...
Infantile neuronal ceroid lipofuscinosis (INCL), the most severe form of lipofuscinoses, is caused by mutations in lysosomal enzyme palmitoyl protein thioesterase 1 (PPT1). Typical symptoms this disease include progressive psychomotor developmental retardation, visual failure, seizures, and premature death. Here, we investigated seizure activity relevant pathological changes PPT1 knock-in mice (PPT1 KI). The behavior studies study demonstrated that KI had no significant until 7 months age,...
Abstract Sept8 is a vesicle associated protein and there are two typical transcriptional variants (Sept8‐204 Sept8‐201) expressed in mice brain. Interestingly, the coexpression of Sept8‐204/Sept5 induces formation small sized vesicle‐like structure, while that Sept8‐201/Sept5 produces large puncta. previously shown to be palmitoylated. Here it was further revealed palmitoylation required for maintain structure colocalize with synaptophysin, since either expression nonpalmitoylated Sept8‐204...
Rationale: Tripeptidyl peptidase II (TPP2) has been proven to be related human immune and neurological diseases.It is generally considered as a cytosolic protein which forms the largest known protease complex in eukaryotic cells operate mostly downstream of proteasomes for degradation longer peptides.However, this canonical function TPP2 cannot explain its role wide variety biological pathogenic processes.The mechanistic interrelationships hierarchical order these processes have yet...
The Schlieren technique is widely adopted for visualizing supersonic jets owing to its non-invasiveness the flow field. However, extending classical method quantitative refractive index measurements cumbersome, especially three-dimensional flows. Background-oriented has gained increasing popularity ease of implementation and calibration. This study utilizes multi-view-based tomographic background-oriented (TBOS) reconstruct axisymmetric weakly non-axisymmetric jets, highlighting impact...
Three-dimensional (3D) density-varying turbulent flows are widely encountered in high-speed aerodynamics, combustion, and heterogeneous mixing processes. Multi-camera-based tomographic background-oriented Schlieren (TBOS) has emerged as a powerful technique for revealing 3D flow density structures. However, dozens of cameras typically required to obtain high-quality reconstructed fields. Limited by the number available optical windows confined space harsh experimental environments, TBOS with...
Tight sandstone has low porosity and permeability, a complex pore structure, strong heterogeneity due to diagenetic modifications. Limited intervals of Lianggaoshan Formation in the Fuling area are cored high costs, thus, model for predicting facies based on logging curves was established few core, thin section, X-ray diffraction (XRD), scanning electron microscopy (SEM), cathodoluminescence, routine core analysis, mercury injection capillary pressure tests. The results show that tight...
The performance for free-pGaN deep-ultraviolet light-emitting diodes (DUV LEDs) is still limited by total internal reflection (TIR), p-electrode absorption, and self-heating effect. In this study, we propose inserting a layer of self-assembled Ni nanoparticle array between p-AlGaN (Ni/Au). experimental results demonstrate that compared to conventional DUV LEDs, the proposed device exhibits significant improvements in optical power, forward voltage, thermal characteristics. This due fact...
Mechanical compaction is an important diagenetic process in sandstone reservoirs. Particle breakage, which commonly occurs during mechanical compaction, plays a significant role controlling the physical properties of reservoir. However, existing numerical simulation methods have limitations simulating when considering particle breakage. In this study, discrete element method was proposed based on cutting, and experimental results reported literature were used to calibrate parameters....
Summary CLN1 disease, also called infantile neuronal ceroid lipofuscinosis, is a fatal neurodegenerative disease caused by mutations in the gene encoding palmitoyl protein thioesterase 1 (PPT1). To identify depalmitoylation substrate of PPT1 crucial to understand disease. In this study, we found that depalmitoylates GABA A R α1 subunit at Cystein-260, while binding Cystein-165 and −179. Mutations or its site result enhanced inhibitory synaptic transmission, strengthened oscillation but...
Taxol has been widely used as an anticancer drug for ovarian, breast, lung and prostate cancer. Some kinds of Taxus plants are distributed in the Northeast Asia region. We have isolated seven tricyclic diterpenoids, taxinine, taxagifine, 5-O-cinnamoyltaxacin I triacetate, 5-decinnamoyltaxinine J, 5-cinnamoyl-9-acetyltaxicin I, taxacin taxol from needles media var. Hicksii, investigated their effects on stimulus-induced superoxide generation translocation cytosolic compounds to cell membrane...
Abstract Mudstone is a typical type of soft rocks. It stable and has high strength in its natural state. However, presence water the constituent minerals dissolve inter-grain bonds are weakened, which thereby greatly reduces mudstone. As one most prevailing geological formations southwestern China, understanding mechanical behaviour mudstone at different degrees disintegration great importance to practical engineering. This paper presents micro-mechanical analysis on using discrete element...
Abstract Palmitoylation is a reversible and dynamic process involving addition of palmitic acid to cysteine residues proteins. Studies have indicated that variety neuronal receptors, including glutamate receptors such as AMPAR, NMDAR, GABA A R, are palmitoylated, which contributes the modulation synaptic strength in response activity. However, little known about depalmitoylation these receptors. In this study, we adopted PPT1-deficient mice, an animal model closely mimics human disease...
<title>Abstract</title> Infantile neuronal ceroid lipofuscinosis (INCL), the most severe form of lipofuscinoses, is caused by mutations in lysosomal enzyme palmitoyl protein thioesterase 1 (PPT1). Typical symptoms this disease include progressive psychomotor developmental retardation, visual failure, seizures, and premature death. Here, we investigated seizure activity relevant pathological changes PPT1 knock-in mice (PPT1 KI). The behavior studies study demonstrated that KI had no...