A5101598162- Neuroscience and Neuropharmacology Research
- Lysosomal Storage Disorders Research
- Functional Brain Connectivity Studies
- Mitochondrial Function and Pathology
- Mental Health Research Topics
- Neurological Disorders and Treatments
- Ion Transport and Channel Regulation
- Transcranial Magnetic Stimulation Studies
- Impact of Technology on Adolescents
- Mesenchymal stem cell research
- Advanced Glycation End Products research
- Protease and Inhibitor Mechanisms
- Biochemical effects in animals
- Sleep and Wakefulness Research
- Cognitive Functions and Memory
- Neural dynamics and brain function
- Blockchain Technology Applications and Security
- Nuclear Receptors and Signaling
- Virus-based gene therapy research
- Signaling Pathways in Disease
- Adenosine and Purinergic Signaling
- Sirtuins and Resveratrol in Medicine
- ATP Synthase and ATPases Research
- Histone Deacetylase Inhibitors Research
- Zebrafish Biomedical Research Applications
Southwest University
2022-2025
Xinxiang Medical University
2019-2024
Henan Psychiatric Hospital
2024
Imperial College London
2023
Northwest Normal University
2021
Zhengzhou University
2019-2020
Henan Provincial People's Hospital
2011-2020
Guangdong Medical College
2015-2016
Zhengzhou People's Hospital
2011
Diabetes severely impairs male reproduction. The present study assessed the effects and mechanisms of action advanced glycation end products (AGEs), which play an important role in development diabetes complications, on testosterone secretion by rat Leydig cells. Primary cells were cultured treated with AGEs (25, 50, 100 200 µg/ml). Testosterone production induced human chorionic gonadotropin (hCG) was determined ELISA. mRNA protein expression levels steroidogenic acute regulatory (StAR),...
Although adipose-derived stem cells (ADSCs) have demonstrated a promising potential for the applications of cell-based therapy and regenerative medicine, excessive reactive oxygen species (ROS) are harmful to ADSCs cell survival proliferation. Vitamin C is an important antioxidant, often added into culture media as essential micronutrient. However, its roles on proliferation human not been studied. Therefore, in this study, were isolated, detected by flow cytometry analysis their surface...
Abstract In recent years, electronic cigarettes (e‐cigs) have gained popularity as stylish, safe, and effective smoking cessation aids, leading to widespread consumer acceptance. Although previous research has explored the acute effects of combustible or nicotine replacement therapy on brain functional activities, studies e‐cigs been limited. Using fNIRS, we conducted graph theory analysis resting‐state connectivity 61 male abstinent smokers both before after vaping e‐cigs. And performed...
Impaired inhibitory control is a core feature of internet addiction disorder (IAD). It therefore interest to determine the neurophysiological markers associated with it. The present study aimed find such biomarkers resting-state electroencephalogram (EEG). We specifically used scores on Chinese Internet Addiction Scale revised edition (CIAS-R) divide 46 participants into two groups: IAD group (>53, n = 23) and (<46, 23). Both behavioral aspects (Go/NoGo responses impulsivity) EEG were...
A disintegrin-like and metalloproteinase with thrombospondin type 1 motifs (ADAMTS1) is a protease involved in fertilization, cancer, cardiovascular development, thoracic aneurysms. Proteoglycans such as versican aggrecan have been identified ADAMTS1 substrates, Adamts1 ablation mice typically results accumulation; however, previous qualitative studies suggested that proteoglycanase activity weaker than of other family members ADAMTS4 ADAMTS5. Here, we investigated the functional...
Social anxiety disorder (SAD) is a common mental health problem, and its core cognitive manifestation the persistent fear of being evaluated, including both negatively (FNE) positively (FPE). This study aimed to examine longitudinal relationships FNE, FPE SAD explore their neural basis.Three samples were retrieved in this study. First, data 649 college students who completed survey fMRI scan used basis FPE, symptoms. Next, 450 participants same twice variables. Finally, overlapping two (N =...
Rationale: Tripeptidyl peptidase II (TPP2) has been proven to be related human immune and neurological diseases.It is generally considered as a cytosolic protein which forms the largest known protease complex in eukaryotic cells operate mostly downstream of proteasomes for degradation longer peptides.However, this canonical function TPP2 cannot explain its role wide variety biological pathogenic processes.The mechanistic interrelationships hierarchical order these processes have yet...
Abstract Background and Aims In the digital age, Internet addiction (IA) was deemed an epidemic few treatments had been effectively developed for it. Here, we proposed a solution-focused group counseling (SFGC) as potentially solution to reduce among college students. The present study examined short- long-term effect of five-week intervention on addiction. Methods Thirty-two participants were recruited randomly assigned either experimental or control group, twenty-six completed whole...
Zebrafish is a widely used animal model with well-characterized background in developmental biology. The fate of human adipose-derived stem cells (ADSCs) after their xenotransplantation into the developing embryos zebrafish unknown. Therefore, ADSCs were firstly isolated, and then transduced lentiviral vector system carrying green fluorescent protein (GFP) reporter gene, followed by detection cell viability expression surface antigens. These GFP-expressing transplanted at 3.3–4.3 hour...
Tissue inhibitor of metalloproteinases‐1 (TIMP‐1) is a multifunctional matrix metalloproteinase, and it involved in the regulation cell proliferation apoptosis various types. However, little known about effect TIMP‐1 expression on adipose‐derived stem cells (ADSCs). Therefore, ADSCs was firstly detected by western blotting, gene knocked down lentivirus‐mediated shRNA. Cell then evaluated MTT assay Ki67 staining, respectively. cycle progression determined flow cytometry. The changes p51, p21,...
Objective To explore the effect of repeated transcranial magnetic stimulation (rTMS) combined with rehabilitation training on motor and non-motor symptoms Parkinson′s disease. Methods A total 150 persons disease were randomly divided into an rTMS group, a group observation each 50. The received only stimulation. standard training. was given both for 4 weeks. overall efficacy treatment evaluated using unified rating scale (UPDRS), while assessed 10 m back-and-forth run test, simple...
Summary CLN1 disease, also called infantile neuronal ceroid lipofuscinosis, is a fatal neurodegenerative disease caused by mutations in the gene encoding palmitoyl protein thioesterase 1 (PPT1). To identify depalmitoylation substrate of PPT1 crucial to understand disease. In this study, we found that depalmitoylates GABA A R α1 subunit at Cystein-260, while binding Cystein-165 and −179. Mutations or its site result enhanced inhibitory synaptic transmission, strengthened oscillation but...
Objective To observe the influence of transcranial direct current stimulation (tDCS) on rapid eye movement sleep disorders among Parkinson′s disease (PD) patients. Methods Fifty-four PD patients were randomly divided into a treatment group (n=28) and control (n=26). Both groups given routine drug nursing, while was additionally provided with tDCS therapy. evaluated using polysomnography (PSG), Hamilton depression scale (HAMD), pediatric daytime sleepiness (PDSS), Epworth sleeping...
Abstract Palmitoylation is a reversible and dynamic process involving addition of palmitic acid to cysteine residues proteins. Studies have indicated that variety neuronal receptors, including glutamate receptors such as AMPAR, NMDAR, GABA A R, are palmitoylated, which contributes the modulation synaptic strength in response activity. However, little known about depalmitoylation these receptors. In this study, we adopted PPT1-deficient mice, an animal model closely mimics human disease...