A5043784736- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Cardiac Ischemia and Reperfusion
- Liver physiology and pathology
- Phytochemistry and Biological Activities
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammasome and immune disorders
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- interferon and immune responses
- Psoriasis: Treatment and Pathogenesis
- Mesenchymal stem cell research
- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- Retinal Diseases and Treatments
- Advancements in Transdermal Drug Delivery
- IL-33, ST2, and ILC Pathways
- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
- Sirtuins and Resveratrol in Medicine
- Inflammatory mediators and NSAID effects
Qingdao University
2013-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2024
Shanghai University
2024
Xijing Hospital
2023
Shanghai Jiao Tong University
2020-2023
Yangzhou University
2023
Anhui Polytechnic University
2023
Third Affiliated Hospital of Guangzhou Medical University
2023
Guangzhou Medical University
2023
Heidelberg University
2018-2022
The effectiveness of transplanted bone marrow mesenchymal stem cells (MSCs) for cardiac repair has been limited; thus, strategies optimizing stem-cell-based myocardial therapy are needed.The present study was designed to test our central hypothesis that hypoxia-preconditioned MSCs (HP-MSCs) more effective than cultured under ambient oxygen levels the treatment injury in a large-scale (N=49), long-term (9 months), nonhuman primate (Cynomolgous monkeys) investigation.MSCs were engineered...
Inflammatory bowel disease (IBD) is a chronic nonspecific with unknown etiology. Currently, the anti-inflammatory therapeutic approaches have achieved certain extent of effects in terms inflammation alleviation. Still, final pathological outcome intestinal fibrosis has not been effectively improved yet.In this study, dextran-coated cerium oxide (D-CeO2) nanozyme superoxide dismutase (SOD) and catalase (CAT) activities was synthesized by chemical precipitation. Our results showed that D-CeO2...
Resveratrol is widely known for its antiaging properties and exerts cardiovascular protective effects in different experimental models. The role of resveratrol regulating mitochondrial functions dynamics during the cardiac aging process remains poorly understood. In this study, on morphology depolarization expressions Drp1, parkin, PINK1, LC3 were investigated H9c2 cells after D‐galactose treatment that induced senescent‐like cardiomyocytes. results show downregulation Drp1 markedly...
Human papillomavirus (HPV)-16 infection may be related to non-smoking associated lung cancer. Our previous studies have found that HPV-16 oncoproteins promoted angiogenesis via enhancing hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF), and interleukin-8 (IL-8) expression in non-small cell cancer (NSCLC) cells. In this study, we further investigated the roles of PI3K/Akt c-Jun signaling pathways it.
The activity and function of T-cells are influenced by the intra- extracellular redox milieu. Oxidative stress induces hypo-responsiveness untransformed T-cells. Vice versa increased glutathione (GSH) levels or decreased reactive oxygen species (ROS) prime T-cell metabolism for inflammation, e.g. in rheumatoid arthritis (RA). Therefore, balancing milieu may represent a promising new option therapeutic immune modulation. Here we show that sulforaphane (SFN), compound derived from plants...
Highlights•DCs do not require MyD88 to expand pathologic T cells in the small intestine•Pathologic APC functions intestine DCs are unique for each subset•Both CD103−CD11b+ and CD103+CD11b+ inflammatory Th17 cells•IL-6 is required, but sufficient, IL-17-inducing of SI-LP DCsSummaryNormal dynamics between microbiota dendritic (DCs) support modest numbers cells, yet these cause inflammation. The that induce signals drive this process remain unclear. Here, we demonstrate lacking signaling...
Although embryonic brain development and neurodegeneration have received considerable attention, the events that govern postnatal maturation are less understood. Here, we identify miR-29 family to be strikingly induced during late stages of maturation. Brain is associated with a transient, period de novo non-CG (CH) DNA methylation mediated by DNMT3A. We examine whether an important function restrict CH via its targeting Dnmt3a. Deletion in brain, or knockin mutations preventing specifically...
Recently, the combination of chemotherapy and chemodynamic therapy (CDT) has become a desirable strategy in treatment cancer. However, satisfactory therapeutic outcome is often difficult to achieve due deficiency endogenous H2O2 O2 tumor microenvironment. In this study, CaO2@DOX@Cu/ZIF-8 nanocomposite was prepared as novel nanocatalytic platform enable CDT cancer cells. The anticancer drug doxorubicin hydrochloride (DOX) loaded onto calcium peroxide (CaO2) nanoparticles (NPs) form CaO2@DOX,...
Adipose tissue contains some populations, adipose-derived stem cells (ADSCs) which can differentiate into adipogenic, chondrogenic, osteogenic, myogenic, and endothelial cells. Furthermore, adipose be easily obtained in large quantities through a simple liposuction. ADSCs are thought to an alternate source of autologous adult for cell-based therapy. However, it is time-consuming inefficient harvest by using traditional collagenase-digestion method. To meet the demand basic applied research...
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease representing serious unmet medical need. The associated with the loss of self-tolerance and exaggerated B cell activation, resulting in autoantibody production formation immune complexes that accumulate kidney, causing glomerulonephritis. TLR7, an important mediator innate response, drives expression type-1 interferon (IFN), which leads to IFN induced genes aggravates lupus pathology. Because lysosomal peptide symporter...
Halofuginone (HF) is an active component of extracts derived from the plant alkaloid febrifugine and has shown therapeutic promise in animal models fibrotic disease. Our main objectives were to clarify suppressive effect HF on concanavalin A (ConA)-induced liver fibrosis. ConA injection into tail vein caused a great increase serum aspartate aminotransferase (AST) alanine (ALT) levels, while orally administration significantly decreased levels transaminases. In addition, hyaluronic acid (HA),...
Abstract Several antitumor therapies work by increasing reactive oxygen species (ROS) within the tumor micromilieu. Here, we reveal that L-plastin (LPL), an established marker, is reversibly regulated ROS-induced thiol oxidation on Cys101, which forms a disulfide bridge with Cys42. LPL reduction mediated Thioredoxin1 (TRX1) system, as shown TRX1 trapping, knockdown and blockade of reductase (TRXR1) auranofin. diminishes its actin-bundling capacity. Ratiometric imaging using LPL-roGFP-Orp1...
The crude extract of Acanthopanax senticosus (AS) has been used extensively in Russia, China, Korea and Japan as an adaptogenic agent to fight against stress fatigue. However, whether the liposoluble fraction possesses antifatigue activity or not is still unclear. A was administered orally mice for 9 days. swimming time exhaustion longer treatment groups (22.2 ± 3.3, 25.5 4.8 min) than control group (13.7 1.2 min, p < 0.05). plasma TG (triglyceride) BUN (blood urea nitrogen) levels high dose...
Piperlongumine (PL), a natural small molecule derived from the Piper longum Linn plant, has received growing interest as prooxidative drug with promising anticancer properties. Yet, influence of PL on primary human T cells remained elusive. Knowledge this is crucial importance, however, since in particular play critical role tumor control. Therefore, we investigated effects survival and function peripheral blood (PBTs). While was not cytotoxic to PBTs, it interfered several stages cell...