A5012298413- Neonatal Health and Biochemistry
- Neuroscience and Neuropharmacology Research
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroscience of respiration and sleep
- Neuroinflammation and Neurodegeneration Mechanisms
- Ion Transport and Channel Regulation
- Neonatal and fetal brain pathology
- Ion channel regulation and function
- Plant Reproductive Biology
- Regulation of Appetite and Obesity
- Livestock and Poultry Management
- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer, Hypoxia, and Metabolism
- Photoreceptor and optogenetics research
- Plant Parasitism and Resistance
- Cardiac Ischemia and Reperfusion
- Chromatography in Natural Products
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Underwater Vehicles and Communication Systems
- Plant Molecular Biology Research
- Zebrafish Biomedical Research Applications
- Photosynthetic Processes and Mechanisms
- Natural product bioactivities and synthesis
Northwest University
2024
Ministry of Education of the People's Republic of China
2024
Shanghai Jiao Tong University
2019-2024
Shanghai Sixth People's Hospital
2019-2024
University of Toronto
2023-2024
Shanghai Center for Brain Science and Brain-Inspired Technology
2024
Hospital for Sick Children
2023-2024
Mental Health Research Canada
2023
Guangdong Ocean University
2019
Chengdu University
2017-2018
Stroke prognosis is negatively associated with an elevation of serum bilirubin, but how bilirubin worsens outcomes remains mysterious. We report that post-, not pre-, stroke levels among inpatients scale infarct volume. In mouse models, increases neuronal excitability and ischemic infarct, whereas insults induce the release endogenous all which are attenuated by knockout TRPM2 channel or its antagonist A23. Independent canonical intracellular agonists, metabolic derivatives gate opening, A23...
Glutamate is traditionally viewed as the first messenger to activate NMDAR (N-methyl-D-aspartate receptor)-dependent cell death pathways in stroke
Plant Elicitor Peptides (Peps) induce plant immune responses and inhibit root growth through their receptors PEPR1 PEPR2, two receptor-like kinases. In our study, we found a previously unknown function of Peps that enhance hair in PEPRs-independent manner. When characterized the expression patterns PROPEP genes, several gene promoters family were particularly active hairs. Furthermore, observed PROPEP2 is vital for development, as disruption led to significant reduction density length. We...
Neonatal hyperbilirubinemia is a common clinical condition that can lead to brain encephalopathy, particularly when concurrent with acidosis due infection, ischemia, and hypoxia. The prevailing view increases the permeability of blood-brain barrier bilirubin exacerbates its neurotoxicity. In this study, we found concentration cell death marker, lactate dehydrogenase (LDH) in cerebrospinal fluid (CSF), elevated infants both showed stronger correlation severity rather than increased...
Hyperbilirubinemia (HB) is a key risk factor for hearing loss in neonates, particularly premature infants. Here we report that bilirubin (BIL)-dependent cell death auditory brainstem of neonatal mice both sexes significantly attenuated by ZD7288, blocker hyperpolarization-activated cyclic nucleotide-gated (HCN) channel mediated current (I
Abstract Neonatal jaundice is prevalent among newborns and can lead to severe neurological deficits, particularly sensorimotor dysfunction. Previous studies have shown that bilirubin (BIL) enhances the intrinsic excitability of central neurons this potentially contribute their overexcitation, Ca 2+ overload, neurotoxicity. However, cellular mechanisms underlying elevated neuronal remain unknown. By performing patch-clamp recordings from neonatal in rat medial vestibular nucleus (MVN), a...
Chlorogenic acid (ChA) is the major compound in Shuang-Huang-Lian (SHL), which mainly composed of ChA, baicalin, and Forsythia suspense Thunb Vahl.The effects co-existing compounds SHL Lonicera japanica on absorption ChA was investigated.According to 3 × Latin-square test, alone, extracts japanica, or mixture baicalin (ChA effective doses 60 mg/kg) separately given six beagles for seven days. The oral pharmacokinetic parameters plasma, urine faeces were quantified by HPLC/UV analyzed.The as...
Zebrafish have the potential to regrow injured organs and tissues, but their use as a model for hearing regeneration following blast injury has never been reported. In this study, zebrafish were exposed wave produced by an underwater generator. The first peak sound pressures generator up 224 dB 160kPa, measured at 25 cm away from machine. sensitivity was examined analyzing auditory evoked potentials 1 35 days post exposure. Cell death cell proliferation in inner ear organs, including...
Glutamate is traditionally viewed as the first messenger to activate N-methyl-D-aspartate receptors (NMDARs) and downstream cell death pathways in stroke 1,2 , but unsuccessful clinical trials with NMDAR antagonists implicate engagement of other NMDAR-independent mechanisms 3–7 . Here we show that glutamate its structural analogs, including antagonist L-AP5 (or APV), robustly potentiated currents mediated by acid-sensing ion channels (ASICs) which are known for driving acidosis-induced...
SUMMARY The sophisticated regulation of state transition is required to maintain optimal photosynthetic performance under fluctuating light condition, through balancing the absorbed energy between photosystem II and I. This exquisite process incorporates phosphorylation dephosphorylation light‐harvesting complexes PSII core subunits, accomplished by thylakoid membrane‐localized kinases phosphatases that have not been fully identified. In this study, one Chlamydomonas high response gene,...
Neuronal excitability is a critical feature of central nervous system development, playing fundamental role in the functional maturation brain regions, including hippocampus, cerebellum, auditory and visual systems. The present study aimed to determine mechanism by which hypoxia causes dysfunction through perturbation neuronal hypoxic neonatal mouse model. Functional development was assessed humans using Gesell Development Diagnosis Scale. In mice, gene transcription evaluated via mRNA...
Quantitative assessment of endogenously synthesized and released bilirubin from brain tissue remains a challenge. Here, we present sensitive reproducible experimental paradigm to quantify, in real time, unconjugated (UCB) isolated murine during oxygen-glucose deprivation (OGD). We describe steps for perfusion, dissection, slice preparation incubation, glucose depletion, OGD processing. then detail procedures standard calibration plotting sample UCB measurement. For complete details on the...
Hepatic encephalopathy (HE)-a major complication of liver disease-has been found to increase the risk olfactory dysfunction, which may be attributed elevated levels ammonia/ammonium in blood and cerebrospinal fluid. However, cellular mechanisms underlying hyperammonemia-induced dysfunction remain unclear. By performing patch-clamp recordings mitral cells (MCs) mouse bulb (OB), we that 3 mM ammonium (NH4+) increased spontaneous firing frequency attenuated amplitude, but synaptic blockers...