A5100459425- Tracheal and airway disorders
- Systemic Lupus Erythematosus Research
- Obstructive Sleep Apnea Research
- Head and Neck Anomalies
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Endometriosis Research and Treatment
- Teratomas and Epidermoid Cysts
- Retinal Imaging and Analysis
- T-cell and B-cell Immunology
- Uterine Myomas and Treatments
- Retinal and Macular Surgery
- Traumatic Ocular and Foreign Body Injuries
- Corneal surgery and disorders
- Retinal Diseases and Treatments
- Airway Management and Intubation Techniques
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- Head and Neck Surgical Oncology
- Ophthalmology and Visual Impairment Studies
- Gut microbiota and health
- Neonatal Health and Biochemistry
- Foreign Body Medical Cases
- Autoimmune Bullous Skin Diseases
Shanghai Children's Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Anhui University
2025
Hangzhou Women’s Hospital
2024
Shanghai University of Medicine and Health Sciences
2024
Sun Yat-sen University
2007-2024
Hebei Medical University
2024
Second Hospital of Hebei Medical University
2024
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Several cross-sectional studies have reported associations between oral diseases and obstructive sleep apnea (OSA). However, there been no reports regarding the structure composition of microbiota with simultaneous evaluation potential perturbed metabolic profiles in pediatric OSA.An integrated approach, combining metagenomics based on high-throughput 16S rRNA gene sequencing, metabolomics ultra-performance liquid chromatography coupled quadrupole time-of-flight mass spectrometry gas...
First branchial cleft anomalies (FBCA) are rare in the clinical setting, as they account for 1 to 8% of all abnormalities. The purpose this study is explore relationship between fistula tract and facial nerve surgical method FBCA. This retrospective included 30 cases FBCA children managed from 2009 2016. All patients underwent surgery remove We reviewed data obtain their demographics management. Thirty (11 male 19 female) with were diagnosed. ages ranged 13 years (median, 3 years). Twenty...
Background/Aims: Osteoarthritis (OA) as a degenerative disease is major problem in ageing populations. To better understand the molecular mechanisms pathogenesis of OA, this study explored role microRNA (miR)-146a articular chondrocytes. Methods: The chondrocyte line ATDC5 was used to simulate inflammatory injury by LPS administration vitro. Cell viability, apoptosis, mRNA expressions and productions factors were assessed, respectively. Mir-146a Cxcr4 measured qRT-PCR. Targeting effect...
Systemic lupus erythematosus (SLE) is an autoimmune-mediated diffuse connective tissue disease characterized by immune inflammation with unclear aetiology and pathogenesis. This work profiled the intestinal flora faecal metabolome of patients SLE using 16S RNA sequencing gas chromatography-mass spectrometry (GC-MS). We identified unchanged alpha diversity partially altered beta flora. Another important finding was increase in Proteobacteria Enterobacteriales decrease Ruminococcaceae among...
Objective:To investigate the safety and efficacy of submucous radiofrequency ablation inferior turbinate, to provide a clinical basis for surgical treatment allergic rhinitis in children. Methods:Patients with obstructive sleep apnea syndrome who were admitted Department Otolaryngology Head Neck Surgery Shanghai Children's Hospital from January 2021 December 2023 underwent bilateral turbinate adenoid tonsil included study. Observational statistical indexes used evaluate curative effect....
Laryngotracheal stenosis (LTS), a pathological narrowing of the upper airway caused by excessive extracellular matrix (ECM) deposition, often leads to dyspnea and even respiratory failure. However, systematic studies addressing specific subpopulations their contribution LTS development still remain underexplored. We collected laryngotracheal tissue at multiple time points rat model, established injuring lining, performed dynamic single-cell RNA sequencing (scRNA-seq) elucidate transcriptomic...
<h3>Background/aim</h3> To assess long-term effects of dexamethasone intravitreal implant (DEX implant) monotherapy on retinal morphology in diabetic macular oedema (DME). <h3>Methods</h3> Two multicentre, masked, phase III studies with identical protocols randomised patients DME, best-corrected visual acuity 34–68 Early Treatment Diabetic Retinopathy Study letters and central subfield thickness (CSRT) ≥300 µm to DEX 0.7, 0.35 mg or sham procedure. Patients were followed up for 3 years (39...
Neonatal hyperbilirubinemia is a common clinical condition that can lead to brain encephalopathy, particularly when concurrent with acidosis due infection, ischemia, and hypoxia. The prevailing view increases the permeability of blood-brain barrier bilirubin exacerbates its neurotoxicity. In this study, we found concentration cell death marker, lactate dehydrogenase (LDH) in cerebrospinal fluid (CSF), elevated infants both showed stronger correlation severity rather than increased...
Clinical observations and molecular analysis of the SMPD1 gene in Chinese patients with acid sphingomyelinase deficiency Niemann-Pick disease (NPD) are scarce.A cohort 27 diagnosed deficiency, within past five years, were collected investigated for genotype, phenotype, their correlations.The majority our (25/27) under 18 years age. From group, eight (30%) fulfilled characters type A. Four other experienced neurologic involvement after two age, these classified as intermediate type. The...
Abstract This study is to evaluate the visual outcome and identify its crucial related factors in children undergoing cataract surgery for bilateral total congenital (CC). prospective included consecutive patients primary at Zhongshan Ophthalmic Center (ZOC), Guangzhou, China from Jan 2010 May 2014. Visual was estimated by best-corrected acuity (BCVA) last follow-up. Potential factors, including gender, age follow-up, surgery, surgical procedure, postoperative complications (PCs), frequency...
China is the only country where nerve growth factor approved for large-scale use as a clinical medicine. More than 10 years ago, in 2003, injection was listed national drug. The goal of this article to evaluate comprehensively efficacy and safety treatment neurological diseases.A computer-based retrieval performed from six databases, including Cochrane Library, PubMed, EMBASE, Sino Med, CNKI, VIP database, searching establishment until December 31, 2013. key words searches were "nerve...
Précis: The overall incidence of postoperative suspected glaucoma and after congenital cataract surgery is low; however, the identification associated risk factors helps to monitor susceptible individuals provide real-time surveillance timely intervention. Purpose: Pediatric patients who have undergone for or infantile cataracts a developing glaucoma, but current evidence does not address our understanding glaucoma/glaucoma application in clinical standard care. Therefore, this study...
There have been few studies on congenital nasal dermoid and sinus cysts (NDSCs) in infants.This study was performed to obtain clinical data for the diagnosis treatment of NDSCs infants.We a retrospective analysis 11 infants admitted with between 2014 2019. Patient demographics, lesion site, preoperative radiological findings, surgical technique, intraoperative postoperative sequelae were analyzed.In total, (average age, 19 months; lowest 10 months) included this study. All patients presented...
Aims To report the incidence and associated risk factors for developing suspected definitive glaucoma after bilateral congenital cataract (CC) removal with a 5-year follow-up. Methods Secondary analysis of prospective longitudinal cohort study. Bilateral CC patients who had undergone surgery between January 2011 December 2014 at Zhongshan Ophthalmic Centre were recruited. Suspected was defined as persistent ocular hypertension requiring medical treatment. Definitive accompanied by...
For medical staff, job satisfaction is essential for advancement on an individual and organizational level. This study looked into the relationships between challenging demands, resources, personal well-being. Additionally, it examined potential mediating effects of emotional exhaustion work motivation within framework demands-resources (JD-R) model. Results from a cross-sectional 267 employees at second-grade comprehensive hospital in Jiangsu, China's mainland, indicated that demands were...