A5069234901- Fibroblast Growth Factor Research
- Toxic Organic Pollutants Impact
- Kruppel-like factors research
- Monoclonal and Polyclonal Antibodies Research
- Insects and Parasite Interactions
- Insect and Pesticide Research
- Glycosylation and Glycoproteins Research
- Cancer-related gene regulation
- Carcinogens and Genotoxicity Assessment
- Adipose Tissue and Metabolism
- Insect and Arachnid Ecology and Behavior
- CAR-T cell therapy research
- Effects and risks of endocrine disrupting chemicals
- Wnt/β-catenin signaling in development and cancer
- Immunotoxicology and immune responses
- Advanced Biosensing Techniques and Applications
- Environmental Toxicology and Ecotoxicology
- Drug Transport and Resistance Mechanisms
- Cancer Cells and Metastasis
- Insect Resistance and Genetics
- Teratomas and Epidermoid Cysts
- Chromatin Remodeling and Cancer
- Porphyrin Metabolism and Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Protein Degradation and Inhibitors
Apath (United States)
2011
Center for Environmental Health
1995-2004
University of California, Davis
1995-2002
Abstract Recent single-cell studies of cancer in both mice and humans have identified the emergence a myofibroblast population specifically marked by highly restricted leucine-rich-repeat-containing protein 15 (LRRC15) 1–3 . However, molecular signals that underlie development LRRC15 + cancer-associated fibroblasts (CAFs) their direct impact on anti-tumour immunity are uncharacterized. Here mouse models pancreatic cancer, we provide vivo genetic evidence TGFβ receptor type 2 signalling...
The mammalian SWItch/Sucrose Non-Fermentable (SWI/SNF) helicase SMARCA4 is frequently mutated in cancer and inactivation results a cellular dependence on its paralog, SMARCA2, thus making SMARCA2 an attractive synthetic lethal target. However, published data indicates that achieving high degree of selective inhibition likely essential to afford acceptable therapeutic index, realizing this objective challenging due the homology with paralog. Herein we report discovery potent...
<h3>Objective</h3> Wnt/Tcf, Lgr5, Ascl2 and/or Bmi1 signalling is believed to define the mouse intestinal stem cell niche(s) from which adenomas arise. The aim of this study was determine relevance these putative markers human colorectal cancer. <h3>Design</h3> 19 markers, including and were identified published data an evaluation a gene expression database. Associations between genes assessed by isotopic in situ hybridisation (ISH) 57 adenocarcinomas. Multiplex fluorescent ISH chromogenic...
Fibroblast growth factors (FGF) play important roles in development, angiogenesis, and cancer. FGF19 uniquely binds to FGF receptor 4 (FGFR4). Our previous study has shown that transgenic tumors have an activated Wnt-pathway phenotype. Wnt signaling is implicated initiating or promoting various cell types organs. In this study, we examined whether inhibition of affects the beta-catenin pathway using human colon cancer lines (HCT116, Colo201). results show increases tyrosine phosphorylation...
Hedgehog (Hh) signaling is critical to the patterning and development of a variety organ systems, both ligand-dependent ligand-independent Hh pathway activation are known promote tumorigenesis. Recent studies have shown that in tumors promoted by ligands, occurs within stromal microenvironment. Testing whether ligand-driven promotes tumor angiogenesis, we found antagonism reduced vascular density Hh-producing LS180 SW480 xenografts. In addition, ectopic expression sonic hedgehog...
The epidermis is a barrier that prevents water loss while keeping harmful substances from penetrating the host. impermeable cornified layer of stratum corneum maintained by balancing continuous turnover driven epidermal basal cell proliferation, suprabasal differentiation, and corneal shedding. desquamation process tightly regulated balance activities serine proteases Kallikrein-related peptidases (KLK) family their cognate inhibitor lymphoepithelial Kazal type-related (LEKTI), which encoded...
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease representing serious unmet medical need. The associated with the loss of self-tolerance and exaggerated B cell activation, resulting in autoantibody production formation immune complexes that accumulate kidney, causing glomerulonephritis. TLR7, an important mediator innate response, drives expression type-1 interferon (IFN), which leads to IFN induced genes aggravates lupus pathology. Because lysosomal peptide symporter...
Significance The ubiquitin ligase CRL4 COP1/DET1 modifies specific transcription factor substrates with polyubiquitin so that they are degraded. However, the Ras–MEK–ERK signaling pathway can inactivate and thereby promote rapid accumulation of these factors. Here we show constitutive photomorphogenesis 1 (COP1) has a critical role in mouse brain development because its deletion from neural stem cells stabilizes factors c-JUN, ETV1, ETV4, ETV5, leading to perturbation normal gene expression...
Squamous cell carcinomas (SCCs) account for the majority of cancer mortalities. Although TP63 is an established lineage-survival oncogene in SCCs, therapeutic strategies have not been developed to target or it's downstream effectors. In this study we demonstrate that directly regulates NRG1 expression human SCC lines and a critical component transcriptional program. Notably, show squamous tumors are dependent signaling vivo, both genetically engineered mouse models xenograft models,...
Abstract Ovarian cancer is a diverse class of tumors with very few effective treatment options and suboptimal response rates in early clinical studies using immunotherapies. Here we describe LY6/PLAUR domain containing 1 (LYPD1) as novel target for therapeutic antibodies the ovarian cancer. LYPD1 broadly expressed both primary metastatic ∼70% prevalence serous subset. Bispecific targeting CD3 on T cells tumor antigen have demonstrated significant activity hematologic cancers. We developed an...
ABSTRACT Organochlorine compounds are known to be atmospherically transported long distances from their original sources. To understand the influence of California's Sierra Nevada range on air transport and subsequent distribution pattern some these residues within range, we have chosen salmonid fish as an indicator species. Fish were collected 10 locations throughout northern central polychlorinated biphenyl (PCB), toxaphene, chlordane, DDT [1,1,1‐trichloro, 2,2′‐bis ( p ‐chlorophenyl)...
Previously, we reported that several of the toxic effects 2,3,7,8-tetrachlorodibenzo-p -dioxin (TCDD) were not fully expressed in c-src −/− and −/+ mice (1). In current study, studied basic molecular mechanism their differential responses. First, could show chemical inhibition kinase produce practically same phenomenon reduced toxicity TCDD wild-type cotreated with geldanamycin, a specific inhibitor known to suppress kinase. Second, established level Ah receptor associated (2) is indeed low...
Chronic kidney disease (CKD) can be characterized by inflammation and fibrosis of the kidney. Although standard care methods have been limited in scope, safety, spatial distribution, MRI diffusion tensor imaging (DTI) has emerged as a promising noninvasive technology to evaluate renal vivo. In this study, we performed DTI an oxalate mouse model CKD systematically identify local injury. parameters strongly correlated with histology, blood biomarkers, hydroxyproline, gene expression.
Abstract We compared the ability of two clonally derived murine preadipocyte cell lines, 3T3‐L1(L1) and 3T3‐F442A (F442A), to differentiate after treatment by 2,3,7,8‐tetrachlorodibenzo‐ p ‐dioxin (TCDD), found that former line was clearly suppressed TCDD but latter not. It initially postulated easiest way explain lack response in F442A cells could be an alteration aryl hydrocarbon receptor (AhR) functionality. This hypothesis tested first, no differences were levels or functions AhR. To...