A5082573738- Fluorine in Organic Chemistry
- Synthesis and Reactions of Organic Compounds
- Inorganic Fluorides and Related Compounds
- Chemical Reactions and Mechanisms
- Chemical Synthesis and Reactions
- Synthesis and properties of polymers
- Anesthesia and Sedative Agents
- Renal function and acid-base balance
- Inorganic and Organometallic Chemistry
- Per- and polyfluoroalkyl substances research
- Non-Invasive Vital Sign Monitoring
- Porphyrin and Phthalocyanine Chemistry
- Renin-Angiotensin System Studies
- 3D Printing in Biomedical Research
- Hemodynamic Monitoring and Therapy
- Synthesis and Catalytic Reactions
- Complement system in diseases
- Nausea and vomiting management
- Physiological and biochemical adaptations
- Carbon dioxide utilization in catalysis
- Cyclopropane Reaction Mechanisms
- Catalysis and Oxidation Reactions
- History and advancements in chemistry
- Chemical Reaction Mechanisms
- Anesthesia and Pain Management
Confluence Life Sciences (United States)
2022-2024
McMaster University
1989-1997
University of Manchester
1980-1989
SickKids Foundation
1987-1988
University of Toronto
1987-1988
Hospital for Sick Children
1987-1988
Institute of Science and Technology
1980
Queen's University
1978
Occidental College
1964
Planaria which have cannibalized untrained planaria exposed to photic stimuli only, handling or previous conditioning, all require significantly fewer trials in a conditioning situation than naive planaria.
The epidermis is a barrier that prevents water loss while keeping harmful substances from penetrating the host. impermeable cornified layer of stratum corneum maintained by balancing continuous turnover driven epidermal basal cell proliferation, suprabasal differentiation, and corneal shedding. desquamation process tightly regulated balance activities serine proteases Kallikrein-related peptidases (KLK) family their cognate inhibitor lymphoepithelial Kazal type-related (LEKTI), which encoded...
N-Fluoroquinuclidinium fluoride, prepared in high yield by treatment of a cold, dilute solution quinuclidine trichlorofluoromethane with fluorine at low pressure specially designed, virtually all glass vacuum system, acts as site-selective electrophilic fluorinating agent towards carbanionic substrates [PhCNa(CO2Et)2→ PhCF(CO2Et)2; Me2CLiNO2→ Me2CFNO2; RMgX → RF (R = Ph, X Br; R c-C6H11, Cl); [graphic omitted]H2→ omitted]HF; PhSiCl3/F–(in situ)→ PhF].
Perfluorovinylsulphur pentafluoride is attacked by sodium methoxide in methanol to give 1,2,2-trifluoro-2-methoxyethylsulphur pentafluoride, and bromine (→ SF5·CFBr·CF2Br), hydrogen bromide SF5·CHF·CF2Br), trifluoroiodomethane SF5·CFl·C2F5) under photochemical conditions monochloride SF5·CFCl·CF2Br, SF5·CFBr·CF2Cl) thermal yield the corresponding 1 : adducts by-products derived from C–S bond fission. Hexafluoro-1,1-di-iodopropane, a by-product of reaction between olefin trifluoroiodomethane,...
1. The rate of smooth muscle cell proliferation in age-matched 1-4-week-old spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats was compared using autoradiography. 2. Labelling index, defined as labelled cells/sum unlabelled cells × 1000, obtained from perfusion-fixed superior mesenteric large arteries. 3. In the arteries, labelling indices were similar between SHR WKY at all age groups, except 1 week when index higher SHR. 4. rat strains groups. 5. We conclude that,...
U.v. irradiation of a mixture sulphur chloride pentafluoride and trifluoroethylene yields (ca. 7 : 3) 2-chloro-1,2,2-trifluoroethylsulphur (I) 2-chloro-1,1,2-trifluoroethylsulphur (II). Both (II) give, inter alia, chlorotrifluoroethylene when pyrolysed. Isomer perfluorovinylsulphur treated with potassium hydroxide, but isomer appears to be completely destroyed by this reagent.
Photochemical isomerization of 1-ethoxycarbonyl-, 1-cyano-, or 1-amido-hexafluoro-1H-azepine yields the respective 2-substituted hexafluoro-2-azabicyclo[3.2.0]hepta-3,6-diene (92–98%).The 2-ethoxycarbonylheptadiene undergoes Diels–Alder addition cyclopentadiene, to give four adducts by exo-attack at CFCF bonds, and furan, three analogous (attack CFCFN bond is preferred), adds phenyl azide reluctantly a 15 : 2 1 mixture adducts, where predominates, gives 3 trans- cis-exo-3,4-dibromides,...
Hexafluorobicyclo[2,2,0]hexa-2,5-diene reacts with chlorine or bromine in the dark to give a mixture of corresponding exo,exo- and trans-5,6-dihalogenohexafluorobicyclo[2,2,0]hex-2-enes; further, photochemical reaction halogen gives all-exo- exo,exo,exo,endo-2,3,5,6-tetrahalogenohexafluoro[2,2,0]hexanes. Catalytic hydrogenation diene at –50° exo-5H,6H/-hexafluorobicyclo[2,2,0]hex-2-ene. Hydrogen bromide adds photochemically mainly bicyclohexene arising from cis,exo-addition; cis,exo-addition...
Hexafluorobicyclo[2.2.0]hexa-2,5-diene is an active dipolarophile, reacting with the representative 1,3-dipoles phenyl azide. diazomethane, 2,2,2-trifluorodiazoethane. 2,4,6-trimethylbenzonitrile oxide, and benzonitrile N-phenylimide to give 1 : adducts, mixtures of 2 adducts. Related compounds are similarly reactive, addition CF:CF double bond 2-methoxypentafluorobicyclo [2.2.0]hexa-2,5-diene, exo-5,6-dibromohexa-fluorobicyclo [2.2.0]hex-2-ene, occurring azide respectively. 19F N.m.r....
The hexafluoro-Dewar-benzene adduct of phenyl azide yields hexafluoro-1-phenyl-1H-azepine on pyrolysis. Reaction ethyl azidoformate with hexafluorobenzene hexafluoro-1H-azepine-1-carboxylate (21%), octafluoronaphthalene 1,2-(ethoxycarbonylimino)-1,2,3,4,5,6,7,8-octafluoro-1,2-dihydronaphthalene (23%), and 1,2,3,4-tetrafluoronaphthalene 1,2-(ethoxycarbonylimino)-1,2,3,4-tetrafluoro-1-1,2-dihydronaphthalene (18%) 5,6,7,8-tetrafluoro-1-naphthylcarbamate (48%). No azepines were obtained from the...
M. G. Barlow, R. N. Haszeldine and W. D. Morton, J. Chem. Soc. D, 1969, 931 DOI: 10.1039/C29690000931
Hexafluoropropene reacts with pentafluorobenzonitrile in the presence of caesium fluoride to give two mono-(2- and 4-), di-(2,4- 2,5-), tri-(2,4,5- 2,4,6-)(perfluoroisopropyl) derivatives; no solvent is necessary. The 2,4,5-derivative rearranges less sterically hindered 2,4,6-derivative when heated ion. ring fluorine atoms perfluoroisopropyl derivatives are highly susceptible nucleophilic displacement; cyano-group resists hydrolysis.
In this study, the cardiac output of 11 children (5 days to 18 yr age) was measured following cardiopulmonary bypass. Standard dye dilution outputs and an indirect Fick-CO2 technique were simultaneously determined. A rebreathing maneuver is described estimate oxygenated mixed venous PCO2 (PvCO2). This PvCO2 combined with end tidal CO2 production give a non-invasive Fick output. Non-invasive correlated well those by dye-dilution (r2 = 0.94) over range from 490-7280 ml/min. All determinations...
Abstract Die Titelverbindung (I) addiert Chlor unter Bildung der Isomeren (IIa) und (IIIa) (bei äquimolarer Chlor‐Menge im Dunkeln bei Raumtemperatur) bzw. (IVa) (Va) Chlorüberschuß Licht).
Abstract Das Perfluorvinylsul?d (II) reagiert mit Na‐methylat zu dem gesättigten Äther (I).
Abstract Die bereits ohne Lösungsmittel in Gegenwart von CsF ablaufende Reaktion zwischen den Titelverbindungen (I) und (II) [Bildung der Produkte (III)‐(VI) Reaktionsbedingungen abhängiger Verteilung] wird untersucht.
Abstract Die Titelverbindung reagiert mit den entsprechenden 1,3‐dipolaren Verbindungen zu 1:1‐Addukten (I) bzw. (II).