A5100337039- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Skin Protection and Aging
- Circular RNAs in diseases
- Dermatology and Skin Diseases
- RNA Interference and Gene Delivery
- Immune cells in cancer
- Pregnancy and preeclampsia studies
- Cancer and Skin Lesions
- Cancer-related molecular mechanisms research
- Bone and Joint Diseases
- Asthma and respiratory diseases
- Bone Metabolism and Diseases
- Contact Dermatitis and Allergies
- Genomics, phytochemicals, and oxidative stress
- melanin and skin pigmentation
- Breast Lesions and Carcinomas
- RNA modifications and cancer
- Bone health and treatments
- Cancer Diagnosis and Treatment
- Neurological and metabolic disorders
- Dermatologic Treatments and Research
- Cardiovascular Disease and Adiposity
- Acne and Rosacea Treatments and Effects
- Genetic and rare skin diseases.
Guangxi Medical University
2013-2025
Nanjing University
2013-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2025
First Affiliated Hospital of GuangXi Medical University
2025
Chinese Academy of Medical Sciences Dermatology Hospital
2025
Kunming University of Science and Technology
2024
Nantong University
2020-2024
Huazhong University of Science and Technology
2024
Hubei Cancer Hospital
2024
Soochow University
2024
Abstract Background Polycyclic aromatic hydrocarbons (PAHs) are of environmental and public health concerns contribute to adverse skin attributes such as premature aging pigmentary disorder. However, little information is available on the potential roles chronic urban PAH pollutant exposure cutaneous microbiota. Given microbiota have healthy undesirable phenotypes relationships between PAHs properties, we hypothesize that may be associated with changes in In this study, over two hundred...
Pleural effusion (PE) is a common clinical complication of many pulmonary and systemic diseases, including lung cancer tuberculosis. Nevertheless, there no effective biomarker to identify the cause PE. We attempted investigate differential expressed exosomal miRNAs in PEs adenocarcinoma (APE), tuberculous (TPE), other benign lesions (NPE) by using deep sequencing quantitative polymerase chain reaction (qRT-PCR). As result, 171 differentiated were observed 3 groups PEs, 11 significantly...
Abstract Secreted microRNAs (miRNAs) are novel endocrine factors that play essential pathological and physiological roles. Here, we report pancreatic β cell‐released exosomal miR‐29 family members (miR‐29s) regulate hepatic insulin sensitivity control glucose homeostasis. Cultured islets were shown to secrete miR‐29s in response high levels of free fatty acids (FFAs) vitro. In vivo, FFAs, promoted by either high‐fat diet (HFD) feeding (physiopathological) or fasting (physiological),...
The process of bone repair is highly regulated by a large number bioactive factors. Thus, "cocktail" factors supplemented to the defect sites desirable for repair. In this regard, small extracellular vesicles (sEVs) derived from mesenchymal stem cells hold great potential in tissue Nevertheless, poor homing and retention sEVs greatly limited their possible clinical application. present work, DMPE-PEG-CREKA was inserted into membrane released adipose-derived obtain CREKA functionalized...
The prediction of side-effects is a key issue in the REACH initiative on chemicals preclinical testing drugs. dermal irritation and skin sensitization toxicity potential new molecule, vitacoxib, were invested rabbits guinea pigs compliance with Organization for Economic Cooperation Development guideline. To assess irritation, dermally attached to vitacoxib 72 h or repeated application. results showed that no adverse reactions such as erythema edema observed throughout test. In test,...
Abstract Serum small extracellular vesicles (sEVs) have recently drawn considerable interest because of the diagnostic and therapeutic potential their miRNAs content. However, characteristics human, mouse rat serum sEVs differences in RNA contents are still unknown. In this study, through nanoparticle tracking analysis sequencing, we found that rat, exhibited distinct sizes particle numbers as well contents. contained not only abundant but also a large number tRNA fragments. Most existed...
The epidermis is a barrier that prevents water loss while keeping harmful substances from penetrating the host. impermeable cornified layer of stratum corneum maintained by balancing continuous turnover driven epidermal basal cell proliferation, suprabasal differentiation, and corneal shedding. desquamation process tightly regulated balance activities serine proteases Kallikrein-related peptidases (KLK) family their cognate inhibitor lymphoepithelial Kazal type-related (LEKTI), which encoded...
Bisphenol A (BPA) is an industrial chemical that commonly found in daily consumer products. BPA reportedly associated with lung diseases. However, the impact of on pulmonary fibrosis (PF) and its possible mechanisms action both remain unclear. PF mouse model was induced by bleomycin (BLM). Mouse fibroblasts (MLG 2908) alveolar epithelial cells (MLE-12) were treated to establish a cell model. Tissue staining, CCK-8 assays, western blot experiments relevant indicator kits used detect evaluate...
The pathogenesis of osteoporosis is considered extremely intricate. Osteoblast differentiation and angiogenesis can greatly affect bone development formation, given their coupling role in these processes. Exosome-mediated miRNA regulates cellular senescence, proliferation, differentiation. However, whether senescent osteoblasts regulate the senescence vascular endothelial cell by through exosomal pathway remains unclear. In this study, could function, promote apoptosis, decrease...
Osteoclasts are of hematopoietic lineage and have the ability to degrade mineralized bone tissues. Abnormalities in osteoclastic activity under certain pathological conditions common diseases such as osteoporosis, osteosclerosis, arthritis. Although many kinds drugs currently used treat they obvious adverse reactions limitations. CYT387 is a new small-molecule Janus kinase (JAK) inhibitor involved hematopoiesis, immune modulation, fertility, lactation, embryonic development. However, it has...
Abstract Cardiac fibrosis is the hallmark of cardiovascular disease (CVD), which leading cause death worldwide. Previously, we have shown that interleukin‐10 (IL10) reduces pressure overload (PO)‐induced cardiac by inhibiting recruitment bone marrow fibroblast progenitor cells (FPCs) to heart. However, precise mechanism FPC involvement in remains unclear. Recently, exosomes and small extracellular vesicles (sEVs) been linked CVD progression. Thus, hypothesized pro‐fibrotic miRNAs enriched...
Abstract The balance among different CD4 + T cell subsets is crucial for repairing the injured spinal cord. Dendritic (DC)‐derived small extracellular vesicles (DsEVs) effectively activate T‐cell immunity. Altered peptide ligands (APLs), derived from myelin basic protein (MBP), have been shown to affect and reduce neuroinflammation levels. However, application of APLs challenging because their poor stability associated side effects. Herein, it demonstrate that DsEVs can act as carriers APL...
Cold has been a long-term survival challenge in the evolutionary process of mammals. In response to cold stress, addition brown adipose tissue (BAT) dissipating energy as heat through glucose and lipid oxidation maintain body temperature, stimulation can strongly activate thermogenesis expenditure beige fat cells, which are widely distributed subcutaneous layer. However, effects on other tissues systemic metabolism remain unclear. Our previous research indicated that, under BAT not only...
Abstract Emerging evidence emphasizes the functional impacts of host microbiome on etiopathogenesis autoimmune diseases, including rheumatoid arthritis (RA). However, there are limited mechanistic insights into contribution microbial biomolecules especially peptides toward modulating immune homeostasis. Here, by mining metagenomics data tonsillar microbiome, a deficiency encoding genes lantibiotic salivaricins in RA patients is identified, which shows strong correlation with circulating...
Numbers of emerging evidence suggest that variable microRNA (miRNA) expression facilitates the aging process. In this study, we distinguished aberrant miRNA in aged skin and explored biological functions potential mechanism upregulated miR-302b-3p. At first, microarray analysis was examined to explore profiling mice model by D-galactose (d-gal) injection. We identified 29 miRNAs skin. Next, KEGG enrichment conducted with DIANA-miPath v3.0, which revealed pathways involved such processes as...
UVB is a high energy source that causes the major risk factor for sunburn and skin tumor. However, photochemical interactions lead to beneficial effects such as synthesis of vitamin D corticosteroids. Therefore, reasonable therapeutic regime advocated reduce injuries but makes use synthesizing sunlight metabolite. Many natural compounds improving plant cells resistant oxidative stress by harnessing solar may be also used protect human cells. Although many nature plants have shown...
As a natural flavonoid compound, rutin could scavenge free radicals effectively to achieve remarkable antioxidant and anti-photoaging activity. Unfortunately, the extremely low water solubility of often leads poor percutaneous permeability unsatisfactory bioavailability, which has greatly restricted its clinical application. In this study, novel freeze-dried nanocrystal was developed improve saturation solubility, further redispersed in carbopol gel formulate targeted (NC-gel) for enhanced...
The structural differences of MYB14 promoter in two grapevine genotypes affect the expression and stilbene synthesis response to Al3+ UV-C radiation. Grapevines provide an important fruit crop worldwide, but production is often limited by pathogen infection. Stilbenes, a class secondary metabolite, represent phytoalexins that contribute defence against pathogens many plants, including grapevine. It known transcription factors MYB15 are required for activation promoters resveratrol synthase...