A5103031719- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Angiogenesis and VEGF in Cancer
- Traditional Chinese Medicine Analysis
- Genomics, phytochemicals, and oxidative stress
- Biomarkers in Disease Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related gene regulation
- Congenital Anomalies and Fetal Surgery
- Cancer Risks and Factors
- Atherosclerosis and Cardiovascular Diseases
- Lipid metabolism and disorders
- Nutritional Studies and Diet
- Extracellular vesicles in disease
- Traditional Chinese Medicine Studies
- Medicinal Plant Pharmacodynamics Research
- Telomeres, Telomerase, and Senescence
- Kruppel-like factors research
- RNA Research and Splicing
- S100 Proteins and Annexins
- Corneal Surgery and Treatments
- Glutathione Transferases and Polymorphisms
- Corneal surgery and disorders
Ningxia Medical University
2020-2025
Ningxia Medical University General Hospital
2025
Jilin University
2019-2024
Shanghai University of Traditional Chinese Medicine
2016-2024
Yueyang Hospital
2016-2024
Central South University
2024
Xi'an Honghui Hospital
2024
Xi'an Jiaotong University
2024
Guangxi Medical University
2019-2021
Guangzhou Vocational College of Science and Technology
2021
Atherosclerosis is one of the most common vascular diseases, and inflammation participates in all stages its progression. Laminar shear stress protects arteries from atherosclerosis reduces endothelial inflammation. Long noncoding RNAs have emerged as critical regulators many including atherosclerosis. However, expression functions long subjected to laminar cells remain unclear. This study aimed reveal mechanism by which stress–regulated contribute anti-inflammation. In this study, we...
The pathogenesis of osteoporosis is considered extremely intricate. Osteoblast differentiation and angiogenesis can greatly affect bone development formation, given their coupling role in these processes. Exosome-mediated miRNA regulates cellular senescence, proliferation, differentiation. However, whether senescent osteoblasts regulate the senescence vascular endothelial cell by through exosomal pathway remains unclear. In this study, could function, promote apoptosis, decrease...
Background: The current study aimed to investigate the molecular mechanism of long non-coding RNA (lncRNA) MEG3 in development breast cancer. Methods: regulating relationships among lncRNA MEG3, miRNA-330 and CNN1 were predicted by bioinformatics analysis cancer samples Cancer Genome Atlas database. differential expression was first validated tissues cells. effects on malignant properties evaluated manipulating its MCF-7 BT-474 Rescue experiments, dual-luciferase assays, immunoprecipitation...
<title>Abstract</title> Background: Disturbance of the immune microenvironment was critical throughout development hepatic fibrosis (HF) to cirrhosis and induction hepatocellular carcinoma (HCC). It is essential explore key biomarkers which related investigate a potential target diagnosis immunological therapy in progression HF HCC. Methods: The GSE89377, GSE63898, GSE84044 Cancer Genome Atlas (TCGA) TCGA-HCC datasets were enrolled screen common differentially expressed genes (co-DEGs) HF,...
Numbers of emerging evidence suggest that variable microRNA (miRNA) expression facilitates the aging process. In this study, we distinguished aberrant miRNA in aged skin and explored biological functions potential mechanism upregulated miR-302b-3p. At first, microarray analysis was examined to explore profiling mice model by D-galactose (d-gal) injection. We identified 29 miRNAs skin. Next, KEGG enrichment conducted with DIANA-miPath v3.0, which revealed pathways involved such processes as...
Background: Triple-negative breast cancer (TNBC) is the most serious subtype of (BC) and has been a great health threat to females. Although chemotherapeutic agent contributes lot TNBC treatment, drug resistance obstacle for chemotherapies. Ursolic acid (UA), pentacyclic triterpenoid compound, was reported reverse paclitaxel in BC. However, whether UA could affect cells other drugs such as doxorubicin (DOX) remains be discovered. Materials Methods: MTT assay, EdU colony formation flow...
Recently, additional long noncoding RNAs (lncRNAs) have been identified and their possible roles were investigated in a variety of human tumors. One these lncRNAs, LINC01929, promoted the progression some cancers, whereas its expression biological function oral squamous cell carcinoma (OSCC) remains still mostly uncertain. The LINC01929 OSCC tissues or lines was via quantitative real-time polymerase chain reaction. counting kit-8, transwell migration, wound-healing, flow cytometry assays...
To construct a free and accurate breast cancer mortality prediction tool by incorporating lifestyle factors, aiming to assist healthcare professionals in making informed decisions.
Background: Long non-coding RNAs (lncRNAs) are pivotal mediators during the development of carcinomas; however, it remains to be investigated whether lncRNAs implicated in oral squamous cell carcinoma (OSCC). Methods: In this study, quantitative real-time PCR was conducted for detecting expression LINC01614 OSCC lines. The biological functions were assessed by loss- and gain-of-function experiments both vivo vitro. Cellular proliferation, migration, invasion herein, dual luciferase reporter...
MicroRNAs (miRNAs) regulate the progression of human malignancy by targeting oncogenes or tumor suppressors, which are 12 promising targets for cancer treatment. Increasing evidence has suggested aberrant expression and tumor-suppressive function miR-1298 in cancers, however, regulatory mechanism breast (BC) remains unclear. Here, our findings showed that was down-regulated BC tissues cell lines. Lower level significantly correlated with advanced patients. Experimental study overexpression...
Cholangiocarcinoma (CCA) is one of the most deadly cancers in world. It usually has a bad prognosis and challenging to identify its early stages. Long noncoding RNAs (lncRNAs) have been shown an increasing number studies be important control signaling pathways, cell behaviors, epigenetic modification that contribute growth tumors. The purpose this work was examine relationship between CCA lncRNA AL161431.1.