A5061481520- Peroxisome Proliferator-Activated Receptors
- Microplastics and Plastic Pollution
- Nanoparticles: synthesis and applications
- Advanced biosensing and bioanalysis techniques
- Wound Healing and Treatments
- Metabolism and Genetic Disorders
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Gastrointestinal motility and disorders
- Lipid metabolism and biosynthesis
- Nanocluster Synthesis and Applications
- Effects and risks of endocrine disrupting chemicals
- Advanced Nanomaterials in Catalysis
- Plant Stress Responses and Tolerance
- Neuroscience and Music Perception
- Adipose Tissue and Metabolism
- Recycling and Waste Management Techniques
- Tendon Structure and Treatment
- Biosensors and Analytical Detection
- Electrospun Nanofibers in Biomedical Applications
- Carbon and Quantum Dots Applications
- Cancer, Lipids, and Metabolism
- CO2 Sequestration and Geologic Interactions
- Plant Gene Expression Analysis
- Hydrocarbon exploration and reservoir analysis
Shandong Normal University
2015-2024
Beihang University
2022-2024
Xi'an Jiaotong University
2020-2024
Guizhou Normal University
2018-2024
State Key Laboratory of Medicinal Chemical Biology
2017-2023
Nankai University
2016-2023
Tulane University
2023
First Affiliated Hospital of Xi'an Jiaotong University
2023
Johns Hopkins University
2001-2022
Kennedy Krieger Institute
2003-2022
Acyl-coenzyme A synthetases (ACSs) catalyze the fundamental, initial reaction in fatty acid metabolism. "Activation" of acids by thioesterification to CoA allows their participation both anabolic and catabolic pathways. The availability sequenced human genome has facilitated investigation number ACS genes present. Using two conserved amino sequence motifs probe DNA databases, 26 family genes/proteins were identified. activity either humans or rodents was demonstrated previously for 20...
Inflammatory bowel disease (IBD) is a chronic nonspecific with unknown etiology. Currently, the anti-inflammatory therapeutic approaches have achieved certain extent of effects in terms inflammation alleviation. Still, final pathological outcome intestinal fibrosis has not been effectively improved yet.In this study, dextran-coated cerium oxide (D-CeO2) nanozyme superoxide dismutase (SOD) and catalase (CAT) activities was synthesized by chemical precipitation. Our results showed that D-CeO2...
Chronic wounds such as diabetic feet undergo a lifetime risk of developing into incurable ulcers. Current treatments for chronic remain unsatisfactory due to the lack ideal wound dressings that integrate facile dressing change, long-acting treatment, and high therapeutic efficacy one system. Herein, synergistically detachable microneedle (MN) with dual-layer structure is presented enable programmed treatment via one-time application. Such MN system (DDMNS) composed chitosan (CS) hydrogel...
As emerging pollutants of global concern, absorbed nanoplastics might have negative impacts on plant development and nutrient uptake, thereby decreasing yields. If are transferred to the edible parts plants, they may pose a threat human health when large quantities ingested. While nanoplastic-induced phytotoxicity is attracting increasing attention, little known about how inhibit nanoplastic accumulation in plants reduce subsequent adverse effects. Here we investigated absorption polystyrene...
Abstract The limitations of protein‐based hydrogels, including their insufficient mechanical properties and restricted biological functions, arise from the highly specific functions proteins as natural building blocks. A potential solution to overcome these shortcomings is development protein–protein which integrate structural functional proteins. In this study, a hydrogel formed by crosslinking bovine serum albumin (BSA) genetically engineered intrinsically disordered collagen‐like protein...
Fatty acid transport protein 4 (FATP4) is a fatty acyl-CoA synthetase that preferentially activates very long chain substrates, such as C24:0, to their CoA derivatives. To gain better insight into the physiological functions of FATP4, we established dermal fibroblast cell lines from FATP4-deficient wrinkle-free mice and wild type (w.t.) mice. FATP4 -/- fibroblasts had no detectable by Western blot. Compared with w.t. fibroblasts, cells lacking an 83% decrease in C24:0 activation. Peroxisomal...
Background The urban environment has been criticized for promoting 'nature-deficit' and 'child-nature disconnectedness'. Keeping in mind the importance of nature exposure its extensive health benefits, many environmental programs around world hope to (re)connect children with nature. To evaluate effectiveness such efforts, valid tools measure Connectedness Nature (CN) are needed but do not exist today, especially use pre-schoolers. Methods original CN Index was modified tested among Parents...
Sweet potato is the sixth most important crop widely cultivated around world with abundant varieties. Different varieties gain different phenolic profiles which has drawn researchers’ attention for its unique health benefits. Our study evaluated profiles, total and cellular antioxidant activities, antiproliferative cytotoxicity in 10 of sweet colours. Among fourteen metabolites detected our study, hyperoside, ferulic acid caffeic were considered as prominent SPSRs. According to principle...
Abstract On‐demand drug delivery systems (DDSs) have tremendous promise for clinical in vivo personalized delivery. However, the current DDSs are monofunctional and unable to meet individualized needs of patients. Herein, a biodegradable multifunctional active‐controlled system (ADDS) is reported. The device can be implanted various tissues with valves controlled by deactivation magnesium (Mg) rapid release from reservoirs long‐term biodegradation ADDS. Multiple chambers constructed...
Nanoplastics (NPs) and acetaminophen (APAP) are thought to be common contaminants invariably detected in the environment. Despite increasing awareness of their toxicity humans animals, embryonic toxicity, skeletal development mechanism action combined exposure have not been clarified. This study was performed investigate whether NPs APAP induces abnormal zebrafish explore potential toxicological mechanisms. All juveniles high-concentration compound group showed some phenomena such as...
Abstract NAC transcription factors are widely distributed in the plant kingdom and play an important role response to various abiotic stresses species. Tritipyrum , octoploid derived from hybridization of Triticum aestivum (AABBDD) Thinopyrum elongatum (EE), is genetic resource for integrating desirable traits Th. into wheat. In this study, we investigated tissue distribution expression genes whole genomes T. after obtaining their complete genome sequences. Based on phylogenetic...
The family of proteins that includes very long-chain acyl-CoA synthetases (ACSVL) consists six members. These enzymes have also been designated fatty acid transport proteins. We cloned full-length mouse Acsvl3 cDNA and characterized its protein product ACSVL3/fatty 3. predicted amino sequence contains two highly conserved motifs characteristic synthetases. Northern blot analysis revealed the mRNA is expressed in adrenal gland, testis, ovary, with lower expression brain adult mice. A...
Detection of circulating tumor cells (CTCs) could be used as a "liquid biopsy" for tracking the spread cancer. In vitro detection methods based on blood sampling and in CTC capture often suffer from small volume error. Here, vivo CTCs transfusion with surface-modified vein indwelling needle is proposed. When was applied to vein, simultaneous performed. To investigate actual efficiency method, labeled MCF-7 were directly injected into veins rabbits, wild type mice, nude mice successfully...