A5100422660- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Diabetes Treatment and Management
- Pain Mechanisms and Treatments
- Spinal Cord Injury Research
- Nerve injury and regeneration
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Mitochondrial Function and Pathology
- Cardiovascular Function and Risk Factors
- Berberine and alkaloids research
- Effects and risks of endocrine disrupting chemicals
- Synthesis and Properties of Aromatic Compounds
- Seaweed-derived Bioactive Compounds
- Iron Metabolism and Disorders
- Polysaccharides and Plant Cell Walls
- Orthopedic Infections and Treatments
- Acupuncture Treatment Research Studies
- Biomarkers in Disease Mechanisms
- Inflammation biomarkers and pathways
- Gastrointestinal motility and disorders
- Bone and Joint Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Nanocluster Synthesis and Applications
- Plant-based Medicinal Research
The University of Texas Health Science Center at Houston
2024
Southern Medical University
2023
The First Affiliated Hospital, Sun Yat-sen University
2022
Sun Yat-sen University
2022
Nanjing Medical University
2014-2022
Tianjin Chest Hospital
2022
Jiangxi University of Traditional Chinese Medicine
2021
Nankai University
2011-2020
State Key Laboratory of Medicinal Chemical Biology
2017-2020
State Key Laboratory of Chemical Engineering
2020
Astragalus membranaceus is a medicinal plant traditionally used in China for variety of conditions, including inflammatory and neural diseases. polysaccharides are shown to reduce the adverse effect levodopa which treat Parkinson’s disease (PD). However, neuroprotective per se PD lacking. Using Caenorhabditis elegans models, we investigated protective astragalan, an acidic polysaccharide isolated from A. , against neurotoxicity 6‐hydroxydopamine (6‐OHDA), neurotoxin that can induce...
Huntington's disease (HD) is a neurodegenerative disorder caused by polyglutamine (polyQ) expansion in Huntingtin protein (Htt). PolyQ Httexp causes selective degeneration of striatal medium spiny neurons (MSN) HD patients. A number previous studies suggested that dopamine signaling plays an important role pathogenesis. specific inhibitor vesicular monoamine transporter (VMAT2) tetrabenazine (TBZ) has been recently approved Food and Drug Administration for treatment patients the USA. TBZ...
Abstract Objective Efficacious modalities are limited in chronic low back pain (cLBP). We determined the efficacy of auricular point acupressure (APA) older adults with cLBP. Methods Participants, ≥ 60 years cLBP, were randomized (1:1:1) to APA ear points targeted cLBP (T-APA, n = 92), non-targeted (NT-APA, 91), or waitlist education control (n 89), and followed up 6 months (6M). Participants groups received 4 weekly sessions; group educational sessions. Primary outcomes function. Results...
Abstract Autophagy is an process for the degradation of cytoplasmic aggregated proteins and damaged organelles plays important role in development SCI. In this study, we investigated therapeutic effect Netrin-1 its potential mechanism autophagy regulation after A rat model SCI was established used analysis. Results showed that administration not only significantly enhanced phosphorylation AMP-activated protein kinase (AMPK) but also reduced mammalian target rapamycin (mTOR) P70S6K. addition,...
Berberine exerts neuroprotective effect in neuroinflammation and neurodegeneration disease. However, berberine acute spinal cord injury is yet to be elucidated. Herein, we investigated the of (SCI). Sprague-Dawley rats were subjected SCI by an intraperitoneal injection post-injury. The neurobehavioral recovery, cytokines pro-inflammatory factors (TNF-α IL-1β), autophagy-related proteins (LC3B, ATG16L, ATG7), apoptosis-related protein cleaved caspase-3 determined. expressions 2',...
Resveratrol exerts protective effects on ovarian injury, decreased oocyte quality and zona pellucida softening due to obesity.
Irritable bowel syndrome (IBS) is associated with a state of chronic visceral hypersensitivity, but the underlying molecular mechanisms hyperalgesia remain elusive. This study was designed to examine changes in excitability and alterations voltage-gated K+ currents subpopulations colonic dorsal root ganglion (DRG) neurons rat model IBS-like hypersensitivity.The hypersensitivity induced by intracolonic infusion 0.5% acetic acid (AA) saline from postnatal days 8 -21. Experiments were conducted...
Recombinant human fibroblast growth factor 10 (rhFGF-10) is frequently used to treat patients with skin injuries. It can also promote hair growth. However, the effective application of rhFGF-10 limited because its poor stability and transdermal absorption. In this study, polymerase chain reaction (PCR) Southern blotting were identify transgenic safflowers carrying a gene encoding an oleosin-rhFGF-10 fusion protein. The size structural integrity in oil bodies extracted from safflower seeds...
Abstract Vascular calcification (VC) has been associated with a risk of cardiovascular diseases. Iron may play critical role in progressive VC. Therefore, we investigated the effects iron overload on aorta rats. A rat model was established by intraperitoneal injection Iron-Dextran. The levels iron, calcium, and ALP activity were detected. Von Kossa staining Perl’s conducted. expression metabolism-related related factors examined aortic tissue results showed serum increased induced excessive...
A shift in the final size distribution and morphology was observed, more pronounced X-ray diffraction peaks were achieved lysozyme crystals with addition of 3D CNMs.
This study aimed to determine whether adrenomedullin (ADM, 7.2 μg/kg/day, ip), an important endogenous active peptide, has a protective role in cardiac remodeling and function obesity-related hypertension (OH) rats. A high-fat diet (HFD) was used induce OH for 20 weeks. H9c2 cells incubated with palmitate (PA, 200 μM) mimic high free fatty acid obesity were as vitro model. In rats, ADM not only decreased body weight (BW) blood pressure (BP) but also improved systemic inflammation oxidative...
Objective Chemotherapy-induced neuropathy (CIN) significantly impacts cancer patients, leading to functional disability, diminished quality of life, and increased healthcare costs amid the ongoing opioid crisis. Auricular point acupressure (APA), a non-invasive non-pharmacological alternative, has shown potential for alleviating pain, numbness, tingling associated with CIN. This study aims assess efficacy APA CIN symptoms physical function examine mechanisms underlying APA’s effects on...
Objective To explore the characteristics and organ maintenance method of brain dead donation donors caused by spontaneous cerebral hemorrhage. Methods The clinical data 71 hemorrhage in our hospital from March 2015 to June 2018 was retrospectively analyzed, then summarized treatment methods donors. Results 67 completed cases, 4 cases were unable donate due sepsis. The kidney 5 discarded because high creatinine value irreversible lesions suggested renal biopsy; liver 1 case not...
Objective To investigate the effects of adiponectin (APN) pretreatment on peripheral blood polymorphonuclear leucocyte (PMN) CD1 1b expression and respiratory burst activity in septic rats.Methods Seventy-two male Sprague-Dawley rats,weighing 250-300 g,were randomly allocated into 3 groups (n =24 each) using a random number table:control group (C group),cecal ligation puncture (CLP) APN (APN group).Sepsis was induced by CLP groups.In group,recombinant 6 mg/kg injected intraperitoneally at 12...