A5024606825- Polysaccharides and Plant Cell Walls
- Gut microbiota and health
- Diet and metabolism studies
- Traditional Chinese Medicine Analysis
- Immune cells in cancer
- Proteoglycans and glycosaminoglycans research
- Glaucoma and retinal disorders
- Pharmacological Effects of Natural Compounds
- Genetics, Aging, and Longevity in Model Organisms
- Glycosylation and Glycoproteins Research
- Probiotics and Fermented Foods
- Phytochemistry and biological activity of medicinal plants
- Metabolomics and Mass Spectrometry Studies
- Phytoestrogen effects and research
- Fungal Biology and Applications
- Ginseng Biological Effects and Applications
- Seaweed-derived Bioactive Compounds
- Medicinal Plants and Bioactive Compounds
- Phytochemicals and Antioxidant Activities
- Immune Response and Inflammation
- Selenium in Biological Systems
- Cancer Cells and Metastasis
- PI3K/AKT/mTOR signaling in cancer
- Chromatography in Natural Products
- Medicinal Plant Pharmacodynamics Research
Lanzhou University
2022-2025
First Hospital of Lanzhou University
2022-2025
Nanchang University
2020-2023
Zunyi Medical University
2023
Infinitus (China)
2012-2022
Jiangmen Polytechnic
2019
Dalian Medical University
2018
Chinese Academy of Agricultural Sciences
2014-2017
Oil Crops Research Institute
2014-2017
South China University of Technology
2011
Inflammatory bowel disease (IBD) results from alterations in intestinal flora and the immune system. Sulfasalazine (SASP) is a sulfa antimicrobial used to treat IBD clinic for years. However, how SASP affects gut microbes its potential functions remains unclear. To investigate relationships of SASP, IBD, microbiome, we 2,4,6-trinitrobenzenesulfonic acid (TNBS) induce experimental colitis rats, analyzed microbiota fecal samples, which come control group (treated with ethanol + saline), model...
Astragalus membranaceus is a medicinal plant traditionally used in China for variety of conditions, including inflammatory and neural diseases. polysaccharides are shown to reduce the adverse effect levodopa which treat Parkinson’s disease (PD). However, neuroprotective per se PD lacking. Using Caenorhabditis elegans models, we investigated protective astragalan, an acidic polysaccharide isolated from A. , against neurotoxicity 6‐hydroxydopamine (6‐OHDA), neurotoxin that can induce...
Polyglutamine (polyQ) aggregation plays a pivotal role in the pathological process of Huntington’s disease and other polyQ disorders. Therefore, strategies aiming at restoring dysfunction reducing stresses mediated by toxicity are therapeutic interest for proteotoxicity diseases. Salidroside, glycoside from Rhodiola rosea, has been shown to have variety bioactivities, including antioxidant activity. Using transgenic Caenorhabditis elegans models, we show here that salidroside is able reduce...
Supplementation with specific <italic>Bifidobacterium</italic> strains will attenuate some hallmark parameters of metabolic syndrome in high-fat–high-sucrose treated rats, elevate the levels SCFAs gut and change microbiota composition beneficially.
The fruits of Lycium barbarum are considered medicinal foods with high nutritional value and bioactivity. In this study, we aimed to evaluate the effect a crude L. polysaccharide (LBP) two derived fractions, LBP-1 LBP-2, on lifespan Drosophila melanogaster (fruit fly). average fruit flies was extended by supplementing their diet either three LBP preparations. vivo analysis antioxidant activities detected increased superoxide dismutase (SOD) catalase (CAT) decreased malondialdehyde (MDA)...
Immunity due to immune balance contributes disease prevention and treatment. Radix Codonopsis polysaccharide (RCP) is isolated from the root of Chinese herb pilosula. Previous studies have indicated that RCP has immunomodulatory activities; however, effects on immunity, especially balance, are still largely unknown. In present study, we investigated T-cell in mice. The mice were pretreated intragastrically with or without for 15 days injected hydrocortisone 10–15 disturb system. spleen...
Epimedium has been traditionally used to treat a variety of medical conditions, including neurological disorders. In this study, an acidic polysaccharide EbPS-A1 is isolated from brevicornum and found contain mainly galacturonic acid, galactose, rhamnose but also arabinose glucuronic acid. Using Caenorhabditis elegans models, we show that capable inhibiting behavioral dysfunction mediated by polyglutamine (polyQ), which implicated in several neurodegenerative disorders such as Huntington's...
Compound polysaccharides may be used as a functional food to modulate the composition and metabolism of gut microbiota, help maintain health intestinal microecosystem.
Chronic pain, or sometimes referred to as persistent reduces the life quality of patients who are suffering from chronic diseases such inflammatory diseases, cancer and diabetes. Hence, herbal medicines draw many attentions have been shown effective in treatment relief pain.Here this study, we used CFA-injected rats a sustainable pain model test anti-inflammatory analgesic effect nutmeg oil, spice flavor additive beverages baked goods produced seed Myristica fragrans tree.We demonstrated...
Polysaccharides can alleviate obesity in mammals; however, studies on mechanism of this alleviation are limited. A few have indicated that polysaccharides improve by regulating the metabolism body. Therefore, a metabolomics approach, consisting high resolution nuclear magnetic resonance (NMR) spectroscopy and multivariate statistical technique, was applied to explore protective effects lentinan Flos Lonicera (LF) high-fat diet (HFD) induced obesity. In study, rats were randomly divided into...
Novel ordered mesoporous silica immobilized lipase arrays are described for enzymatic deacidification of the high-acid rice bran oil and simultaneous preparation phytosterol esters-enriched functional oil.
Lycium barbarum polysaccharide (LBP) is isolated from the fruit of Chinese herbal . Previous studies had demonstrated that LBP could inhibit tumor growth and enhance immunity in mice. However, effect on systemic local immune responses vivo , especially phenotypic functional changes T cells, still largely unknown. In present study, we investigated effects cell-dependent antitumor H22 tumor-bearing The results showed solid mice, but little body weight or spleen index. Furthermore, maintain...
Despite decades of research, malignant tumors are extremely difficult to eliminate with conventional methods. Although surgical resection potentially eradicates the problem, only a few cases suitable for operation, and other approaches often involve harmful consequences. Revolutionary methods desperately needed improve patient outcomes diminish side effects. Myeloid-derived suppressor cells (MDSCs), downregulators innate adaptive immune systems, have been widely studied over past 2 decades....
The aim of the present study was to investigate whether fraction from Lycium barbarum polysaccharide (LBP) could reduce immunotoxicity and enhance antitumor activity doxorubicin (Dox) in mice. A water-soluble LBP fraction, designated LBP3, isolated edible Chinese herbal used this study. To effect LBP3 on Dox-induced immunotoxicity, tumor-free mice were treated with either normal saline, Dox, or Dox plus LBP3. H22 tumor-bearing results showed that did not protect against body weight loss...
The present study aimed to use a chemometric compare the in-vitro antioxidant activities and bioactive compounds of flaxseed based on variety geographical origins, further explore specific components constructed endogenous system in China. differential contents α-linolenic acid (35.83–58.91%), lignans (11.37–33.31 mg/g), total phenolic acids (109.93–246.88 mg/100 g) phytosterols (56.52–125.12 mg/g) 32 varieties were observed. Concomitantly, varied from 32.56 46.22 mg TE/100 g, 0.58 1.08...
A combination of probiotics and polysaccharides may be used as a functional food to modulate the composition function gut microbiota.