Abstract: Liver cancer is a leading cause of deaths worldwide. The combination therapy cytotoxic and chemosensitizing agents loaded in nanoparticles has been highlighted as an effective treatment for different cancers. However, such studies liver remain very limited. In our study, we aim to develop novel lipid with doxorubicin (DOX) (an drug cancer) curcumin (Cur) (a chemosensitizer) simultaneously, examined the efficacy chemotherapy cancer. DOX Cur codelivery (DOX/Cur-NPs) were successfully...

Gynura procumbens (Lour.) Merr. is a plant used in traditional Chinese medicine that reduces hepatotoxicity, relieves kidney discomfort, and has anti-inflammatory antioxidant properties. We aimed to explore the mechanisms underlying therapeutic effects of an ethanol extract from G. stems (EEGS) selected metabolites on injury renal anemia associated with chronic disease (CKD). An adenine-induced rat CKD model was elucidate effective mechanism EEGS correct anemia. The results showed treatment...

The present study aimed to evaluate the hepatoprotective effect and mechanism of action Gynura procumbens on acute chronic ethanol-induced liver injuries. Ethanol extract from G. stems (EEGS) attenuated serum alanine aminotransferase levels hepatic lipid accumulation. Therefore, EEGS was successively extracted by petroleum, ethyl acetate, n-butyl alcohol. results showed that alcohol active fraction EEGS, hence it further fractionated a polyamide glass column. 60% ethanol-eluted contained...

Chronic pain, or sometimes referred to as persistent reduces the life quality of patients who are suffering from chronic diseases such inflammatory diseases, cancer and diabetes. Hence, herbal medicines draw many attentions have been shown effective in treatment relief pain.Here this study, we used CFA-injected rats a sustainable pain model test anti-inflammatory analgesic effect nutmeg oil, spice flavor additive beverages baked goods produced seed Myristica fragrans tree.We demonstrated...

Introduction Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer kind. According to recent research, a fatty increases risk of hepatocellular cancer. Nevertheless, AMPK signaling pathway crucial. In addition, 5’-AMP-activated protein kinase (AMPK) strongly linked alterations in tumor microenvironment, such as inflammation, hypoxia, and aging. The objective this study evaluate impact on progression HCC. Methods study, we established mouse model using high-fat diets...

Gynura procumbens (Lour.) Merr., utilized in traditional Chinese medicine, is known for its liver-protective, liver-soothing, and depression-alleviating properties. This research examines the antidepressant anti-hyperprolactinemia potentials of an ethanol extract from G. stems (EEGS) specific metabolites. To model depression hyperprolactinemia, chronic unpredictable mild stress (CUMS) was induced mice risperidone administered to rats, respectively. Treatments involved administering low (5...

Polyaniline nanomaterial (nPANI) is getting popular in many industrial fields due to its conductivity and stability. The fate effect of nPANI the environment paramount importance towards technological applications. In this work, cytotoxicity nPANI, which was prepared by rapid surface polymerization, studied on rat celiac macrophages. Cell viability macrophages treated with various concentrations different periods ranging from 24 72 hours tested a MTT assay. Damages structures were evaluated...

Electroacupuncture (EA) is reported to effectively relieve the central poststroke pain (CPSP). However, underlying mechanism remains unclear. The present study investigated detailed mechanisms of action EA treatment at different frequencies for CPSP. A CPSP model was established with a single collagenase injection left ventral posterolateral nucleus thalamus. EA-treated groups then received frequency 2, 2/15, or 15 Hz 30 min daily five days. pain-related behavioral responses, neuronal...

Background: Although substance P (SP) is an important primary afferent modulator in nociceptive processes, it unclear whether SP regulates its own release from sensory neurons. Results: Using a highly sensitive radioimmunoassay for SP, we have demonstrated that the activation of neurokinin-1 receptor by or GR73632 (a potent agonist) triggered increase cultured adult rat dorsal root ganglion (DRG) neurons depending on dose and exposure time within 60 min, thereafter, level gradually decreased...

How β-catenin/COX-2 contribute to inflammation-induced fibroblasts migration remains poorly understood. Therefore, in this study, lipopolysaccharide (LPS) was used as a stimulus accelerate the of NIH3T3 cells, which mimicked tissue repair process. LPS treatment increased cell concentration-and time-dependent manner. And NS398, COX-2 inhibitor, inhibited LPS-induced cells migration. DKK-1, an antagonist Wnt/β-catenin signaling, also that However, TWS119, inducer β-catenin via GSK-3β, or...

Microporous organic capsules with hollow interiors have received enormous attention due to their unusual encapsulation efficiency confine chemicals within cavities and prompted controlled release by circumventing ripening or poisoning. To this end, herein, we report the design synthesis of carboxylic group functionalized microporous (HMOCs) using a facile emulsion polymerization technique that show extraordinary high (up 98%) morphine·HCl its promising prolonged release. The HMOCs are found...

Invasion to lymphatic vessels and metastasis lymph nodes are frequent complications in invasive micropapillary carcinoma (IMPC) of human breast cancer. Vascular endothelial growth factor‐C (VEGF‐C) its receptor, VEGFR‐3 have been implicated as the important factors formation recent experimental evidence strongly suggests that lymphangiogenesis tumor promotes metastasis. To clarify mechanism occurrence, expression VEGF‐C, vessel density (LVD) was examined 40 cases IMPC (pure mixed type)...

Background and aims: Lipid nanoparticles (LNs) are widely applied in drug delivery systems because they can incorporate stabilize lipophilic hydrophilic molecules. LNs generally considered quite safe convenient for vivo applications. However, we previously observed that certain types of could cause a loss Kupffer cells, kind resident macrophage the liver. As result, investigated details this phenomenon. Methods: MTT assay, Annexin-V-FITC/PI double staining, JC-1 flow cytometry, Western blot...

Liver cancer is one of the most common malignant tumors, with death rate ranking fourth among all types cancer. Over past few decades, several studies have reported that liver tumorigenesis associated dysfunction in autophagy. However, detailed mechanism remains unclear. In this paper, we used tissue micro-array (TMA) to detect proteins regulation autophagic signaling non-cancerous and cancerous regions by immunohistochemical staining. Those contained 4-HNE, p-AMPK, Erk1/2, p-Erk1/2, CARM1,...

Abstract It has been reported that massive levels or/and high frequency exposure of diethylnitrosamine could induce hepatic neoplasm. However, it would be more interesting to figure out the hepatotoxic effects at trace level and low frequency, which common in our daily life. We found both mRNA protein expression β-catenin were aberrant all liver tissues, accompanied by inflammation, steatosis, fibrosis neoplasm after 10-week (dissolved sesame oil, 0.16 mmol per kg body weight) mice. In...