A5101442804- Hair Growth and Disorders
- Cancer-related molecular mechanisms research
- Skin and Cellular Biology Research
- Wnt/β-catenin signaling in development and cancer
- Medicinal Plants and Neuroprotection
- Infection Control and Ventilation
- Lipid metabolism and biosynthesis
- Essential Oils and Antimicrobial Activity
- Antioxidant Activity and Oxidative Stress
- Effects and risks of endocrine disrupting chemicals
- RNA Research and Splicing
- Alzheimer's disease research and treatments
- dental development and anomalies
- Biological and pharmacological studies of plants
- Cholinesterase and Neurodegenerative Diseases
- Neurological Disease Mechanisms and Treatments
- Phytochemical and Pharmacological Studies
- Skin Protection and Aging
- Traditional Chinese Medicine Analysis
- Drug-Induced Hepatotoxicity and Protection
- Mitochondrial Function and Pathology
- Air Quality and Health Impacts
- Phytochemicals and Medicinal Plants
- Additive Manufacturing and 3D Printing Technologies
- Medicinal Plants and Bioactive Compounds
Chifeng University
2020-2021
Dalian University of Technology
2021
Inner Mongolia Agricultural University
2017-2020
Northwest A&F University
2019
Guangdong Pharmaceutical University
2016-2017
China Pharmaceutical University
2011-2013
Astragalus membranaceus is a medicinal plant traditionally used in China for variety of conditions, including inflammatory and neural diseases. polysaccharides are shown to reduce the adverse effect levodopa which treat Parkinson’s disease (PD). However, neuroprotective per se PD lacking. Using Caenorhabditis elegans models, we investigated protective astragalan, an acidic polysaccharide isolated from A. , against neurotoxicity 6‐hydroxydopamine (6‐OHDA), neurotoxin that can induce...
Glutamate excitotoxicity is associated with many neurological diseases, including cerebral ischemia and neurodegenerative diseases. Tanshinone IIA, a diterpenoid naphthoquinone from Salvia miltiorrhiza, has been shown to suppress presynaptic glutamate release, but its protective mechanism against glutamate-induced neurotoxicity lacking. Using SH-SY5Y human neuroblastoma cells, we show here that excessive exposure decreases cell viability proliferation increases LDH release. Pretreatment...
Abstract Inner Mongolia cashmere goats, as an important part of animal husbandry production, play role in fiber industry. In recent years, scientific research has made a lot explorations on the molecular regulation mechanism hair follicle cycle growth, but few studies have been reported development fetal period. This study was based completion 21 skin samples mRNA and miRNA sequencing 7 periods (45 days, 55 days,65 days,75 days,95 days,115 days 135 days) Cashmere goat. The target genes...
ABSTRACT A rapid, sensitive and specific high‐performance liquid chromatography/electrospray ionization mass spectrometric (LC‐ESI‐MS) method was developed validated for the quantification of madecassoside, a major active constituent Centella asiatica (L.) Urb. herbs, in rat plasma. With paeoniflorin as an internal standard (IS), simple liquid–liquid extraction process employed plasma sample preparation. Chromatographic separation achieved within 6 min on Shim‐pack CLC‐ODS column using...
Inner Mongolia cashmere goat marks a precious gerplasm genetic resource due to its excellent traits. Therefore, it is of crucial importance investigate the development mechanism and search for important growth-related candidate genes. Fetal skin samples at 10 different periods were collected in this research. Moreover, high-throughput sequencing was conducted on RNA from side fetuses three critical hair follicle initiation, growth (namely, 45, 55 65 days) after balanced mix line with...
Objective This study investigated the expression of genes in cashmere goats at different periods their fetal development. Methods Bioinformatics analysis was used to evaluate data obtained by transcriptome sequencing fetus skin samples collected from Inner Mongolia on days 45, 55, and 65 age. Results We found that FoxN1, FoxE1, FoxI3 Fox gene family were probably involved growth development follicle formation hair, which is consistent with previous findings. Real-time quantitative polymerase...
The undercoat fiber of the cashmere goat, from secondary hair follicle (HF), possesses commercial value. However, very few studies have focused on molecular details primary and HF initiation development in goat embryos. In this study, skin samples at embryonic day 45, 55, 65 (E45, E55, E65) were collected prepared for RNA sequencing (RNA-seq). We found that probably initiated E55 to E65 by analyzing functional pathways differentially expressed genes (DEGs). Most key canonical signaling...
Abstract. This study is focused on the detection of ectodysplasin A (EDA) and receptor (EDAR) mRNA expression levels protein positions in seven stages cashmere goat fetus development (45, 55, 65, 75 95, 115, 135 d), with main goal investigating effect EDA EDAR genes related to hair follicle development. Quantitative real-time polymerase chain reaction (RT-qPCR) was used measure Immunohistochemistry (IHC) locate critical stage fetal (45–135 d). fibroblasts epithelial cells interfered by short...
MicroRNAs (miRNAs), a class of 22 nucleotide (nt) noncoding RNAs, negatively regulate mRNA posttranscriptional modification in various biological processes. Morphogenesis skin hair follicles cashmere goats is dynamic process involving many key signaling molecules, but the associated cellular mechanisms induced by these molecules have not been reported. In this study, differential expression, bioinformatics, and Gene Ontology/Kyoto Encyclopedia Genes Genomes enrichment analyses were performed...