Dong Chen

ORCID: 0000-0002-7692-7529
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About
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Research Areas
  • Diabetic Foot Ulcer Assessment and Management
  • Wound Healing and Treatments
  • Sexual function and dysfunction studies
  • Herpesvirus Infections and Treatments
  • Spinal Fractures and Fixation Techniques
  • Cancer Immunotherapy and Biomarkers
  • Renal Diseases and Glomerulopathies
  • Pressure Ulcer Prevention and Management
  • Hormonal and reproductive studies
  • Cancer Diagnosis and Treatment
  • Renal Transplantation Outcomes and Treatments
  • Growth Hormone and Insulin-like Growth Factors
  • Cardiac tumors and thrombi
  • Chemokine receptors and signaling
  • Esophageal and GI Pathology
  • Congenital Anomalies and Fetal Surgery
  • RNA modifications and cancer
  • Urinary Bladder and Prostate Research
  • Cardiovascular Function and Risk Factors
  • Breast Cancer Treatment Studies
  • Congenital gastrointestinal and neural anomalies
  • Organ and Tissue Transplantation Research
  • Venous Thromboembolism Diagnosis and Management
  • Chronic Kidney Disease and Diabetes
  • COVID-19 Clinical Research Studies

Capital Medical University
2014-2024

Beijing Hospital of Traditional Chinese Medicine
2022-2024

Huazhong University of Science and Technology
2007-2024

Union Hospital
2024

Qingdao University of Science and Technology
2024

Qingdao University of Technology
2024

Wenzhou Medical University
2019-2023

Beijing Ditan Hospital
2023

University of New Orleans
2023

Townsville Hospital
2023

Background Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a common disease of urology, which the pathogenesis and therapy remain to be further elucidated. Quercetin has been reported improve symptoms CP/CPPS patients. We aimed verify therapeutic effect quercetin on identify mechanism responsible for it. Methods A novel model induced with Complete Freund Adjuvant in Sprague Dawley rats was established prostates blood specimens were harvested measurement after oral...

10.1002/pros.23536 article EN The Prostate 2018-04-13

Bone is one of the common metastatic sites lung cancer, and its prognosis not optimistic. We performed a study to evaluate incidence, survival, prognostic factors cancer with bone metastasis (LCBM) at initial diagnosis, develop nomogram predict outcomes.We conducted retrospective choosing 13,541 patients LCBM from Surveillance, Epidemiology, End Results (SEER) 18 registry database. An X-tile analysis provided optimal age cutoff point. The overall were evaluated according patient information,...

10.21037/tlcr.2019.08.16 article EN Translational Lung Cancer Research 2019-08-01

Abstract Stromal cell-derived factor 1 (SDF-1) is a chemokine that can be expressed in injured cardiomyocytes after myocardial infarction (MI). By combining with its receptor CXCR4, SDF-1 induced stem and progenitor cells migration. CXCR7, novel for SDF-1, has been identified recently. We aimed to explore the roles of SDF-1/CXCR4 SDF-1/CXCR7 pathway their crosstalk CSCs In present study, CXCR4 CXCR7 expression were CSCs. Transwell assay showed caused migration dose- time-dependent manner,...

10.1038/srep16813 article EN cc-by Scientific Reports 2015-11-18

Objective: The aim of this study is to analyze the microbiological characteristics diabetic foot ulcer (DFU) and drug resistance multidrug-resistant organisms (MDROs) reveal potential risk factors for MDROs. This provides a basis early empiric antibiotic treatment. Methods: included 348 patients with in Chu Hsien-I Memorial Hospital & Metabolic Disease Tianjin Medical University between May 2020 November 2021. A total 475 strains bacteria were cultured, among which 240 bacteria, accounting...

10.2147/idr.s359157 article EN cc-by-nc Infection and Drug Resistance 2022-04-01

RNA secondary structure elements in the mRNA 3'-untranslated regions (3'UTR) play important roles post-transcriptional regulation. viral provide valuable model for studying diverse regulation mechanisms. Herpesvirus genomes are double-stranded DNA with GC-rich sequences, which can be transcribed into abundant RNAs. It is to explore structures and function of those We identified a G2-quadruplex-forming sequence named PQS18-1 3'UTR unique immediate early gene Pseudorabies virus (PRV), an...

10.1080/15476286.2020.1731664 article EN RNA Biology 2020-02-19

For patients with de novo stage IV breast cancer (BC), the conditions under which primary tumor resection (PTR) may offer benefit remain unclear.

10.1080/14737140.2024.2428695 article EN Expert Review of Anticancer Therapy 2024-11-10

Aging-related ED is predominantly attributed to neurovascular dysfunction mediated by NO suppression and increased oxidative stress in penis. The alterations of protein arginine methyltransferases 1 (PRMT1)/dimethylarginine dimethylaminohydrolase (DDAH)/asymmetrical dimethylarginine (ADMA)/NO synthase (NOS) pathway regulate production the vascular endothelium. Epigallocatechin-3-gallate (EGCG) one most abundant antioxidative ingredients isolated from green tea. In present study, 40...

10.4103/1008-682x.178486 article EN cc-by-nc-sa Asian Journal of Andrology 2016-03-10

<h3>Importance</h3> The incidence of hepatoblastoma is increasing, and liver transplant (LT) provides a potential cure for pediatric patients with unresectable hepatoblastoma; however, the use LT has not been examined in modern cohort. Moreover, data are lacking on association between type surgical management received overall risk death among hepatoblastoma. <h3>Objectives</h3> To examine receipt to assess survival who were treated chemotherapy after or resection (LR) using from national...

10.1001/jamanetworkopen.2019.12676 article EN cc-by-nc-nd JAMA Network Open 2019-10-04

Abstract The reward system plays a vital role in drug addiction. purpose of this study is to investigate the structural connectivity characteristics and driving-control subnetwork patterns circuits heroin abusers assess genetic modulation on network. We first defined network based systematic literature review, built diffusion tensor imaging data 78 (HAs) 79 healthy controls (HCs) using connectomics. Then we assessed factors that might modulate changes by performing imaging-genetic screening...

10.1038/s41398-018-0180-0 article EN cc-by Translational Psychiatry 2018-07-30

The undercoat fiber of the cashmere goat, from secondary hair follicle (HF), possesses commercial value. However, very few studies have focused on molecular details primary and HF initiation development in goat embryos. In this study, skin samples at embryonic day 45, 55, 65 (E45, E55, E65) were collected prepared for RNA sequencing (RNA-seq). We found that probably initiated E55 to E65 by analyzing functional pathways differentially expressed genes (DEGs). Most key canonical signaling...

10.1038/s41598-019-54315-7 article EN cc-by Scientific Reports 2019-11-28

Abstract Rationale: Coronavirus disease 2019 (COVID-19) is a novel infectious and became global issue. Treatment of COVID-19 especially in solid organ transplant recipients empirical controversial, the adjustment immunosuppressants. Patient concerns: A 29-year-old kidney recipient with symptoms pneumonia. Diagnoses: pneumonia after transplantation. Interventions: He was treated modified immunosuppressants (unchanged dose tacrolimus oral corticosteroids while discontinuing mycophenolate...

10.1097/md.0000000000020481 article EN cc-by-nc Medicine 2020-06-11

Adults of alveolar Echinococcus species with different uterine structures were collected from Vulpes corsac in the Hulunbeier Pasture Northeastern China 2001. They multilocularis Leuckart, 1863 (type No. 3, similar to E. m. multilocularis), vaselike uterus; cf. sibiricensis Rausch et Schiller, 1954 1), pyriform and sp. 2) spherical uterus at segment top. The metacestode development rodents also differed among those 3 parasites. In case 3), many germinal cells grew on inner surface early...

10.1645/ge-3526.1 article EN Journal of Parasitology 2006-08-01

There are different characteristics of BC in developing countries and developed countries. We intended to study the factors which influence survival prognosis between southern China United States. (a) To two groups patients from 2001 2016 SEER database 1975 2016. (b) register, collect analyze clinicopathological features treatment information. Our found that there significant differences tumor size, positive lymph node status KI-67 cohort (P < 0.000). The may be one causes difference...

10.1038/s41598-022-14573-4 article EN cc-by Scientific Reports 2022-06-21
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