A5101721251- Genetic and phenotypic traits in livestock
- Wastewater Treatment and Nitrogen Removal
- Cancer-related molecular mechanisms research
- Genetic Mapping and Diversity in Plants and Animals
- Hair Growth and Disorders
- Endoplasmic Reticulum Stress and Disease
- Water Quality Monitoring and Analysis
- Animal Genetics and Reproduction
- Ammonia Synthesis and Nitrogen Reduction
- Autophagy in Disease and Therapy
- Effects of Environmental Stressors on Livestock
- Constructed Wetlands for Wastewater Treatment
- CRISPR and Genetic Engineering
- Genetics and Plant Breeding
- RNA regulation and disease
- Circular RNAs in diseases
- RNA Research and Splicing
- Escherichia coli research studies
- Reproductive Physiology in Livestock
- Skin and Cellular Biology Research
- Salmonella and Campylobacter epidemiology
- Craniofacial Disorders and Treatments
- Veterinary medicine and infectious diseases
- Bacterial Genetics and Biotechnology
- thermodynamics and calorimetric analyses
Inner Mongolia Agricultural University
2015-2025
Inner Mongolia University of Science and Technology
2025
China Pharmaceutical University
2025
State Key Laboratory of Natural Medicine
2025
Jiangsu University of Science and Technology
2024
Ministry of Agriculture and Rural Affairs
2024
Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences
2013-2024
Northwest A&F University
2022-2023
Shanghai Jiao Tong University
2023
Northwestern Polytechnical University
2023
To date, 39 single nucleotide polymorphisms (SNPs) have been associated with blood pressure (BP) or hypertension in genome-wide association studies whites. Our hypothesis is that the loci/SNPs BP/hypertension are also BP response to antihypertensive drugs.We assessed of these loci atenolol hydrochlorothiazide monotherapy 768 hypertensive participants Pharmacogenomics Responses Antihypertensive study. Linear regression analysis was performed on whites for each SNP an additive model adjusting...
Inner Mongolia and Liaoning cashmere goats are two outstanding Chinese multipurpose breeds that adapt well to the semi-arid temperate grassland. These characterized by their soft fibers, thus making them great models identify genomic regions associated with fiber traits. Whole-genome sequencing of 70 produced more than 5.52 million single-nucleotide polymorphisms 710,600 short insertions deletions. Further analysis these genetic variants showed some population-specific molecular markers for...
Chlorine treatments are used in water and wastewater sanitation; the resistance of Escherichia coli to chlorine is thus concern public health. We show that a genetic island termed locus heat (LHR) protects E. not only against but also other oxidizing chemicals, adding our knowledge tools by resist stress. Specific detection oxidation different cellular targets combination with cloning fragments LHR provided insight into mechanisms protection demonstrated protect targets. In , presence...
The cashmere goat industry is one of the main pillars animal husbandry in Inner Mongolia Autonomous Region, and plays an irreplaceable role local economic development. With change feeding methods environment, produced by goats shows a tendency coarser, yield can not meet consumption demand people. However, genetic basis behind these changes fully understood. We measured traits, including (CY), diameter (CD), thickness (CT), fleece length (FL) traits for four consecutive years, utilized...
Salinity stress is a major abiotic factor that adversely affects plant growth and development. This study investigated the physiological molecular responses of Brassica rapa L. ssp. Pekinensis to salinity by subjecting seedlings varying concentrations NaCl. Physiological analysis revealed significant wilting, chlorosis, marked reduction in chlorophyll carotenoid contents NaCl-treated seedlings, indicating impaired photosynthetic efficiency oxidative mitigation. RNA-seq identified extensive...
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12864-024-10249-7.
The Inner Mongolia cashmere goat is a local breed valued for both its and meat production. Early growth traits include birth weight weaning weight. Generally, goats with higher weights tend to exhibit carcass at slaughter. Consequently, exploring the genetic variation associated these early crucial in enhancing production performance of goats. For this study, we performed genome-wide association analysis haplotype on 212 (72 rams, 140 ewes) identify molecular markers haplotypes significantly...
Pancreatic cancer is one of the most common malignant tumors digestive system, with majority patients not succumbing to primary tumor but rather metastasis. Epithelial-mesenchymal transition (EMT) abnormally activated in numerous cancers, whereby it promotes cell migration and invasion. Yes-associated protein 1 (YAP1) commonly overexpressed various types plays an oncogenic role. We demonstrated that FV-429, a derivative natural flavonoid wogonin, inhibited invasion metastasis pancreatic...
Abstract Crossovers generated by homologous recombination ensure proper chromosome segregation during meiosis. Crossover interference results in chiasmata being more evenly distributed along chromosomes, but the mechanism underlying crossover remains elusive. Based on large pedigrees of Holstein and Jersey cattle with genotype data, we extracted three-generation families, including 147,327 male 71,687 female meioses Holstein, 108,163 37,008 Jersey, respectively. We identified crossovers...
Objective: Body weight is an important economic trait for a goat, which greatly affects animal growth and survival. The purpose of this study was to identify genes associated with birth (BW), weaning (WW), yearling (YW). Materials Methods: In study, genome-wide association (GWAS) BW, WW, YW determined using the GGP_Goat_70K single-nucleotide polymorphism (SNP) chip in 1,920 Inner Mongolia cashmere goats. Results: We discovered that 21 SNPs were significantly BW on levels. These located 10...
Due to recent innovations in gene editing technology, great progress has been made livestock breeding, with researchers rearing gene-edited pigs, cattle, sheep, and other livestock. Gene-editing technology involves knocking in, out, deleting, inhibiting, activating, or replacing specific bases of DNA RNA sequences at the genome level for accurate modification, such processes can edit genes a fixed point without needing templates. In years, although clustered regularly interspaced short...
Fast and deep debromination of polybrominated diphenyl ethers (PBDEs) under mild conditions is a challenge in the field pollution control. A strategy was developed to achieve it by exploiting Cu/TiO2 composites as noble-metal-free catalyst. Toward 2,2',4,4'-tetrabromodiphenyl ether (BDE47) typical PBDE, use catalyst hydrazine hydrate (N2H4·H2O) reducing agent yielded degradation removal 100% efficiency 87.7% 3 s. complete BDE47 at 1500 mg L-1 possible successively adding N2H4·H2O. pathway...
Objective Mature hair follicles represent an important stage of follicle development, which determines the stability structure and its ability to enter cycle. Here, we used weighted gene co-expression network analysis (WGCNA) identify hub genes mature skin in Inner Mongolian cashmere goats. Methods We transcriptome sequencing data for goats from fetal days 45–135 days, divided co expressed into different modules by WGCNA. Characteristic values were screen out that highly follicles. Module...
microRNA (miRNA) is a type of endogenous short-chain non-coding RNA with regulatory function found in eukaryotes, which involved the regulation variety cellular and biological processes. However, research on development cashmere goat secondary hair follicles still relatively scarce. In this study, small libraries mRNA 45 days, 55 65 75 days fetal skin goats were constructed, constructed sequenced using Illumina Hiseq4000, expression profiles miRNA obtained. The differentially expressed...
As a charismatic species, cashmere goats have rich genetic resources. In the Inner Mongolia Autonomous Region, there are three goat varieties named and approved by state. These renowned for their high production superior quality. Therefore, it is vitally important to protect resources as they will serve breeding material developing new in future.
Abstract Compared with the commercially available single nucleotide polymorphism (SNP) chip based on Bead Chip technology, solution hybrid selection (SHS)-based target enrichment SNP is not only design-flexible, but also cost-effective for genotype sequencing. In this study, we propose to design an animal using SHS-based strategy first time. As update international collaboration goat research, a 66 K cashmere was created from whole-genome sequencing data of 73 individuals. Verification 436...
The function of human Golgi antiapoptotic proteins (GAAPs) resembles that BAX inhibitor-1, with apoptosis inhibition triggered by intrinsic and extrinsic stimuli. However, little is known about the GAAP-related in plants. Here, we studied Arabidopsis GAAP1 GAAP3 found they were localized on cellular membrane, including endoplasmic reticulum (ER) membrane. GAAP1/GAAP3 ER-stress response was tested, results showed single or double mutation reduced plant survival enhanced cell death under ER...
Hair follicle stem cells (HFSCs) have been shown to be essential in the development and regeneration of hair follicles (HFs). The Inner Mongolia Cashmere goat (Capra hircus) has two types HFs, primary secondary, with cashmere being produced from secondary follicle. To identify genes associated growth, transcriptome profiling anagen telogen HFSCs was performed by RNA-Seq. RNA-Seq analysis generated over 58 million clean reads each group, 2717 differentially expressed (DEGs) detected between...