A5065825530- Bone Tissue Engineering Materials
- Supramolecular Chemistry and Complexes
- Supramolecular Self-Assembly in Materials
- Dental Implant Techniques and Outcomes
- Dental materials and restorations
- Oral microbiology and periodontitis research
- Neuroinflammation and Neurodegeneration Mechanisms
- Polymer composites and self-healing
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Aerogels and thermal insulation
- Advanced Materials and Mechanics
- Titanium Alloys Microstructure and Properties
- Renal Diseases and Glomerulopathies
- Endoplasmic Reticulum Stress and Disease
- Luminescence and Fluorescent Materials
- Heat shock proteins research
- Periodontal Regeneration and Treatments
- Silicone and Siloxane Chemistry
- Higher Education and Teaching Methods
- Chronic Kidney Disease and Diabetes
- Liver Disease Diagnosis and Treatment
- Parasites and Host Interactions
- Pickering emulsions and particle stabilization
Xi'an Jiaotong University
2010-2025
Shanghai Jiao Tong University
2012-2025
First Affiliated Hospital of Xi'an Jiaotong University
2025
Kunming University of Science and Technology
2024
Fujian Medical University
2018-2024
Jiangnan University
2024
China Medical University
2015-2024
Zhejiang University
2023-2024
Wuxi People's Hospital
2018-2024
Qilu Hospital of Shandong University
2024
<h3>Objectives</h3> Long non-coding RNAs (lncRNA) have been shown to play important roles in the development and progression of cancer. However, functional lncRNAs their downstream mechanisms are largely unknown molecular pathogenesis oesophageal adenocarcinoma (EAC) its progression. <h3>Design</h3> that abnormally upregulated EACs were identified by RNA-sequencing analysis, followed quantitative RT-PCR (qRTPCR) validation using tissues from 25 EAC patients. Cell biological assays...
Nature has been inspiring scientists to fabricate impact protective materials for applications in various aspects. However, it is still challenging integrate flexible, stiffness-changeable, and properties into a single polymer, although these merits are of great interest many burgeoning areas. Herein, we report an impact-protective supramolecular polymeric material (SPM) with unique impact-hardening reversible stiffness-switching characteristics by mimicking sea cucumber dermis. The...
Although PTEN/Akt signaling is frequently deregulated in human gastric cancers, the vivo causal link between its dysregulation and tumorigenesis has not been established. Here we show that inactivation of PTEN mouse epithelium initiates spontaneous carcinogenesis with complete penetrance by 2 months age. Mechanistically, activation Akt suppresses abundance p53, leading to decreased transcription miR-365, thus causing upregulation cyclin D1 cdc25A, which promotes cell proliferation....
Abstract Mortise‐and‐tenon joints have been widely used for thousands of years in wooden architectures virtue their artistic and functional performance. However, imitation similar structural mechanical design philosophy to construct mechanically adaptive materials at the molecular level is a challenge. Herein, we report mortise‐and‐tenon joint inspired interlocked network (MIN), which [2]rotaxane crosslink not only mimics structure, but also reproduces its function modifying properties MIN....
Abstract Integrating individual microscopic motion to perform tasks in macroscopic sale is common living organisms. However, developing artificial materials which molecular-level motions could be amplified behave macroscopically still challenging. Herein, we present a class of mechanically interlocked networks (MINs) carrying densely rotaxanated backbones as model system understand mechanical properties stemmed from the integration and amplification intramolecular embedded [2]rotaxane...
Owing to their low density, high porosity and unique micro-nanostructures, aerogels are attractive for application in various fields; however, they suffer from shrinkage and/or cracking during preparation, mechanical brittleness, production efficiency non-degradation. Herein, we introduce the concept of dynamic covalent polymer chemistry produce a new class aerogels-referred as DCPAs. The resulting lightweight DCPAs have potential be prepared on large scale feature (90.7%-91.3%), degrees...
Mechanically interlocked molecules are considered promising candidates for the construction of self-adaptive materials by virtue their fascinating structural and dynamic features. However, it is still a great challenge to fabricate such with higher complexity richer functionality. Herein, we propose concept mechanically aerogels (MIAs) in which three-dimensional (3D) porous frameworks made dense modules, thereby enabling integration mechanical adaptivity multifunctionality single entity. The...
Ferroptosis is an iron-dependent cell death and associated with cancer therapy. Can it play a role in resistance of postoperative infection implants, especially extracellular supplement Fe ions non-cytotoxic dose? To answer this, "nanoswords" Fe-doped titanite are fabricated on Ti implant surface to resist bacterial invasion by synergistic action ferroptosis-like bacteria killing, proton disturbance, physical puncture. The related antibiosis mechanism explored atomic force microscopy genome...
Polycatenanes are extremely attractive topological architectures on account of their high degrees conformational freedom and multiple motion patterns the mechanically interlocked macrocycles. However, exploitation these peculiar structural dynamic characteristics to develop robust catenane materials is still a challenging goal. Herein, we synthesize an oligo[2]catenane that showcases properties at both microscopic macroscopic scales. The key feature design controlling force-bearing points...
Abstract Methicillin‐resistant Staphylococcus aureus (MRSA) is threatening human health due to its resistance multiple antibiotics. Excessive copper (Cu) ions target the lipoylated proteins of tricarboxylic acid cycle cancer cells, inducing proteotoxic stress and their cuproptosis death. Whether plays a part in killing MRSA by low‐dose supplement Cu remains be explored. Herein, Cu‐doped hydroxyapatite nanorods (PC) are prepared on polyetheretherketone (PEEK) resist infection improve PEEK...
The energy dissipative features of hydrogen bonds under conditions mechanical strain have provided an ongoing incentive to explore bonding units for the purpose controlling and customizing properties polymeric materials. However, there remains a need bond that (1) possess directionality, (2) provide selectivity, (3) dissipate effectively, (4) can be incorporated readily into materials regulate their properties. Here, we report mechanically interlocked incorporate multiple within [2]catenane...
Mechanically interlocked networks (MINs) with dense mechanical bonds can amplify the dynamic behaviors of to exhibit decent properties. Energy dissipation resulting from bond motion is essential for improving toughness, yet effective strategies optimize this process remain underexplored. Here, by designing models controllable mobility, we establish a fortification strategy two key factors governing energy dissipation, host–guest recognition and sliding friction, thereby enabling property...
Context: Hypoxic-ischemic encephalopathy (HIE) has a high morbidity and mortality rate. Resveratrol possesses numerous biological properties including antioxidant, anti-inflammatory neuroprotective activities.Objective: The current experiment investigates the efficacy of resveratrol (RESV) against HIE by modulating Nrf2/HO-1 pathway in neonatal rats.Materials methods: Seven-day-old pups (n = 48) were divided into four groups. Group-I rats receiving 2% DMSO saline (sham), group-II underwent...
Abstract Photosensitizer protoporphyrin IX (PpIX) fluorescence, intracellular localization and cell response to photodynamic therapy (PDT) were analyzed in MCF10A normal breast epithelial cells a panel of human cancer including estrogen receptor (ER) positive, epidermal growth factor 2 (HER2) positive triple negative (TNBC) after treatment with PpIX precursor aminolevulinic acid (ALA). Although fluorescence was heterogeneous different cells, TNBC showed significantly lower level than ER- or...
Abstract The integration of three-dimensional (3D) bioprinted scaffold’s structure and function for critical-size bone defect repair is immense significance. Inspired by the basic component innate cortical tissue—osteons, many studies focus on biomimetic strategy. However, complexity hierarchical microchannels in osteon, requirement mechanical strength bone, biological angiogenesis osteogenesis remain challenges fabrication osteon-mimetic scaffolds. Therefore, we successfully built mimetic...
A number of epidemiological and clinical studies have suggested an inverse association between allergy helminth infection, such as Schistosomiasis. Therefore, we hypothesize that Schistosoma japonicum egg antigens, a type native antigen, can induce production CD4(+) CD25(+) T cells with regulatory activity, modulating airway inflammation inhibiting asthma development. The frequency was determined by flow cytometry for mice treated ovalbumin (OVA), depletion/OVA, schistosome antigens/OVA...
Long noncoding RNAs (lncRNAs) have been acknowledged as important regulators in various human cancers. lncRNA MNX1-AS1 has shown to be an oncogene epithelial ovarian cancer. However, the function of glioblastoma (GBM) remains largely unknown. Here we found that expression was significantly upregulated GBM tissues and cell lines. Knockdown inhibited proliferation, migration, invasion cells. In terms mechanism, could bind miR-4443 Overexpression vice versa. Moreover, there inverse correlation...
An ideal intraosseous transcutaneous implant should form a tight seal with soft tissue, besides requirement of osseointegration at the bone-fixed position. Si substituted hydroxyapatite (Si-HA) nanorods releasing ion and simulating nanotopography natural tissue were designed on Ti to enhance fibroblast response
Titanium is widely utilized for manufacturing medical implants due to its inherent mechanical strength and biocompatibility. Recent studies have focused on developing coatings impart unique properties Ti implants, such as antimicrobial behavior, enhanced cell adhesion, osteointegration. Ca- Si-based ceramic (CS) can enhance bone integration through the release of Ca Si ions. However, high degradation rates CS ceramics create a basic environment that reduces viability. Polymeric or...
Abstract Bone defects are seriously threatening the health of orthopedics patients and it is difficult for implants to accelerate bone regeneration without using growth factors. Herein, a fast photothermal ion therapeutic strategy developed based on bandgap engineering nanostructured TiO 2 through (Si/P)‐dual elemental doping by micro‐arc oxidation treatment titanium implants. The can tune surface structure decreasing broadening valence band simultaneously, which confirmed density functional...