A5004864827- Proteoglycans and glycosaminoglycans research
- Fibroblast Growth Factor Research
- Glycosylation and Glycoproteins Research
- Breast Cancer Treatment Studies
- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- Medicinal Plant Pharmacodynamics Research
- Colorectal Cancer Treatments and Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Cancer Mechanisms and Therapy
- Advanced Breast Cancer Therapies
- Venous Thromboembolism Diagnosis and Management
- Cancer Genomics and Diagnostics
- Economic and Financial Impacts of Cancer
- PI3K/AKT/mTOR signaling in cancer
Beijing Hospital of Traditional Chinese Medicine
2017-2025
Capital Medical University
2017-2025
Henan Cancer Hospital
2024
Zhengzhou University
2024
Capital University
2024
Beijing University of Chinese Medicine
2024
Science for Life Laboratory
2020
For patients with de novo stage IV breast cancer (BC), the conditions under which primary tumor resection (PTR) may offer benefit remain unclear.
Elemene (ELE), a natural plant drug extracted from Curcumae Rhizoma, has been widely used for cancer treatment in China more than 20 years. Although it is reported to be broad‑spectrum anticancer drug, the mechanism underlying action of ELE breast remains fully elucidated. Heparanase, mammalian endo‑D‑glucuronidase, involved degradation extracellular matrix (ECM), and thus promotes tumor progression metastasis. The downregulation heparanase can effectively reduce malignant behaviors. In...
The current criteria for defining the recurrence risks of stage II colorectal cancer (CRC) are not robust; therefore, we aimed to explore novel gene signatures predict and reveal underlying mechanisms CRC. First, expression profiles 124 patients with CRC from Cancer Genome Atlas (TCGA) database were obtained screen differentially expressed genes (DEGs). A total 202 DEGs, including 128 upregulated 74 downregulated, identified in group (n = 24) compared nonrecurrence 100). Furthermore, top 5...
Gleditsiae Spina, widely used in traditional Chinese medicine, has a good curative effect on malignant tumors such as ovarian cancer, but the mechanism is not clear. So, we aimed to analyze pharmacological of Spina treatment high-grade serous cancer (HGSC) based network pharmacology and biological experiments.The main active ingredients were identified by high performance liquid chromatography (HPLC) mass spectrometry (MS), performed ADME screening. The component targets screened using...
The hypercoagulable status, which forms a vicious cycle with hematogenous metastasis, is common systemic alteration in cancers. As modeling key approach research, model suitable for studying how the status promotes metastasis breast cancer urgently needed.
Abstract Anti-angiogenic therapy sometimes triggers alternative vasculogenic mimicry, which is a predictor of poor prognosis. Researches on angiogenesis and mimicry double-related targets the mechanism behind them could help with this dilemma. The interaction between HS growth factors in extracellular matrix can affect various biological behaviors cells, including tumor cells. Heparinase III from Flavobacterium heparin an enzyme primarily degrading heparan sulfate (HS). Using heparinase...