A5100429584- DNA Repair Mechanisms
- Extracellular vesicles in disease
- Cancer-related gene regulation
- Hippo pathway signaling and YAP/TAZ
- Cardiac Imaging and Diagnostics
- MicroRNA in disease regulation
- Chromatin Remodeling and Cancer
- Protein Degradation and Inhibitors
- Liver physiology and pathology
- Sphingolipid Metabolism and Signaling
- Phytoplasmas and Hemiptera pathogens
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Antiplatelet Therapy and Cardiovascular Diseases
- Fibroblast Growth Factor Research
- Coronary Interventions and Diagnostics
- Cocoa and Sweet Potato Agronomy
- Epigenetics and DNA Methylation
- Advanced X-ray and CT Imaging
- Acute Myocardial Infarction Research
- Traditional Chinese Medicine Analysis
- Inflammasome and immune disorders
- Advanced MRI Techniques and Applications
- Genomics and Phylogenetic Studies
- Immune cells in cancer
Guizhou University
2022-2025
Children's Hospital of Fudan University
2022-2025
University of Michigan
2023-2025
Sichuan University
2022-2025
Kunming Medical University
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Institute of Entomology
2025
First Affiliated Hospital of Kunming Medical University
2025
Capital Medical University
2015-2024
Nanjing University of Chinese Medicine
2022-2024
Coronary revascularization is among the most common hospital-based major interventional procedures performed in United States. It uncertain how new technologies, clinical evidence from trials, and updated guidelines have influenced volume distribution of coronary revascularizations over past decade.
<b><i>Background:</i></b> Hyperglycemia during acute ischemic stroke may augment brain injury, predispose to intracerebral hemorrhage (ICH), or both. <b><i>Method: </i></b> To analyze the relationship between admission glucose level and clinical outcomes from stroke, authors performed multivariate regression analysis with National Institute of Neurological Disorders Stroke recombinant tissue plasminogen activator (rt-PA) Trial data. Neurologic improvement was defined as on NIH Scale by 4...
To ascertain if preoperative short-term radiotherapy followed by chemotherapy is not inferior to a standard schedule of long-term chemoradiotherapy in patients with locally advanced rectal cancer.Patients distal or middle-third, clinical primary tumor stage 3-4 and/or regional lymph node-positive cancer were randomly assigned (1:1) (25 Gy five fractions over 1 week) four cycles (total neoadjuvant therapy [TNT]) (50 25 5 weeks, concurrently capecitabine [chemoradiotherapy; CRT]). Total...
In the SWI/SNF chromatin-remodeling complex, mutually exclusive catalytic ATPase subunits SMARCA2 and SMARCA4 proteins have a synthetic-lethal relationship. Selectively targeting for degradation is promising new therapeutic strategy human cancers harboring inactivated mutated SMARCA4. this study, we report design, synthesis, biological evaluation of novel SMARCA2/4 ligands our subsequent design PROTAC degraders using high-affinity SMARCA VHL-1 ligands. Our efforts led to discovery...
NLR family pyrin domain containing 3 (NLRP3) inflammasome accompanies chronic liver injury and is a critical mediator of inflammation-driven fibrosis. Sphingosine 1-phosphate (S1P)/S1P Receptor (S1PR) signaling participates in fibrogenesis by affecting bone marrow (BM)-derived monocytes/macrophages (BMMs) activation. However, the relationship between S1P/S1PRs NLRP3 BMMs remains unclear. Here, we found significantly elevated gene expression components (NLRP3, pro-interleukin-1β,...
Abstract Inappropriate neutrophil infiltration and subsequent extracellular trap (NET) formation have been confirmed to be involved in chronic inflammatory conditions. Fatty liver disease is an increasingly severe health problem worldwide currently considered the most common cause of disease. Sphingosine 1-phosphate (S1P), a product membrane sphingolipid metabolism, regulates vital physiological pathological actions by inducing activation various cell types through S1P receptors (S1PRs)....
SMARCA2 is an attractive synthetic lethality target for human cancers with SMARCA4 deficiency. Herein, we report the design, synthesis, and biological evaluation of selective protein degraders developed using proteolysis targeting chimera (PROTAC) technology. Our efforts have led to discovery a series potent degraders, exemplified by SMD-3040. SMD-3040 degrades low nanomolar DC50 Dmax > 90% demonstrates excellent degradation selectivity over protein. It displays cell growth inhibitory...
With the development of social economy, ecological environment damage has become increasingly serious, and how to better protect security gradually attracted people's attention. This paper takes Hubei Province in China as research object, using PLUS model version 1.4 design four scenarios predict land use cover changes (LUCC) 2035: natural scenario (S1), cultivated protection (S2), area restriction (S3), pattern (ESP) (S4). The study evaluates effects under these different Conefor Sensinode...
342 Background: With the publication of several clinical research results, efficacy ICI combined with chemotherapy has gradually been recognized in HER-2 negative advanced GC field. We analyzed 1st-line PD-1 inhibitor patients using real-world data and conducted exploratory analysis. aim to identify factors that can predict treatment efficacy, provide a basis for practice. Methods: prospectively collected from between November 2020 April 2024. The staging was stage IV. All were HER2 pMMR....
Little is known about how different financial incentives between Medicare Advantage and fee-for-service (FFS) reimbursement structures influence use of cardiovascular procedures.To compare regional procedure rates FFS beneficiaries.Cross-sectional study beneficiaries older than 65 years 2003-2007 comparing coronary angiography, percutaneous intervention (PCI), artery bypass graft (CABG) surgery across 32 hospital referral regions in 12 states.Rates PCI, CABG surgery.We evaluated a total...
Fisetin, a natural flavonoid found in variety of edible and medical plants, has been suggested to inhibit the proliferation various tumor cells induce apoptosis. However, effects fisetin on breast cancer have rarely reported underlying mechanism is still undefined. The present study explored anti‑cancer mammary carcinoma mechanisms. Following treatment with fisetin, viability 4T1, MCF‑7 MDA‑MB‑231 were measured by MTT assay. inhibitory proliferation, migration invasion evaluated 4T1 using...
Here microRNAs (miRNAs) with potentially therapeutic effects were screened and explored during liver fibrogenesis angiogenesis via targeting the important mediators. Chimera mice EGFP+ bone marrow mesenchymal stromal cells (BMSCs) fed methionine-choline-deficient high-fat (MCDHF) diet to induce injury. Increased expression of platelet-derived growth factor receptor-beta (PDGFR-β) was detected in MCDHF mice, a positive correlation fibrosis markers. BMSCs contributed significant proportion...
Abstract Biliary atresia (BA) is a severe inflammatory and fibrosing neonatal cholangiopathy disease characterized by progressive obstruction of extrahepatic bile ducts, resulting in cholestasis hepatic failure. Cholestasis may play an important role the fibrotic pathological processes, but its specific mechanism still unclear. Necroptosis mediated Z-DNA-binding protein 1 (ZBP1)/phosphorylated-mixed lineage kinase domain-like pseudokinase (p-MLKL) prominent pathogenic factor diseases,...
Abstract Abundant cellular transcripts occupy most of the sequencing reads in transcriptome, making it challenging to assay for low-abundant transcripts. Here, we utilize adaptive sampling function Oxford Nanopore selectively deplete and enrich RNAs interest without biochemical manipulation before sequencing. Adaptive performed on a pool vitro transcribed resulted net increase 22-30% proportion population. Enriching depleting different proportions Candida albicans transcriptome also 11-13.5%...
The aim of this study was to investigate the use de-blooming algorithm in coronary CT angiography (CCTA) for optimal evaluation calcified plaques. Calcified plaques were simulated on a vessel phantom and cardiac motion phantom. Two convolution kernels, standard (STND) high-definition (HD STND), used imaging reconstruction. A dedicated processing. We found smaller bias towards measurement stenosis using (STND: 24.6% vs 15.0%, range 10.2% 39.0% 4.0% 25.9%; HD STND: 17.9% 11.0%, 8.9% 30.6% 0.5%...
The present study was designed to examine whether rabbits fed a diet containing high fat and sucrose could develop obesity insulin resistance (IR), the major pathophysiological features of metabolic syndrome. Male Japanese white were either normal chow (control) or (HFSD) for 36 weeks. Plasma levels triglycerides (TG), total cholesterol (TC), glucose measured. To evaluate metabolism, we performed an intravenous tolerance test. In addition, compared adipose tissue accumulation in HFSD-fed...
The biological roles of sphingosine 1-phosphate (S1P) and S1P receptors (S1PRs) have been broadly investigated. However, at present pathophysiological S1P/S1PRs axis in liver fibrosis are not well defined. Here, we investigated the functions human hepatic stellate cells (HSC) line, LX-2 cells. We found that S1PR types 1, 2 3 (S1PR1-3) clearly detected cells, as determined by RT-PCR, Western blot immunocytochemistry analysis. exerted a powerful migratory action on Boyden chambers, stimulated...