A5103274339- Endometrial and Cervical Cancer Treatments
- Management of metastatic bone disease
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Advanced Radiotherapy Techniques
- Cervical Cancer and HPV Research
- Head and Neck Cancer Studies
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Esophageal Cancer Research and Treatment
- Ovarian cancer diagnosis and treatment
- Atrial Fibrillation Management and Outcomes
- Autophagy in Disease and Therapy
- Colorectal Cancer Surgical Treatments
- MRI in cancer diagnosis
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Atherosclerosis and Cardiovascular Diseases
- Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Advanced biosensing and bioanalysis techniques
- Breast Cancer Treatment Studies
Jilin University
2016-2025
Union Hospital
2016-2025
Xinjiang Medical University
2025
Wuhan University
2010-2024
Wuhan Asia Heart Hospital
2010-2024
Guangdong University of Finance
2023-2024
Guangzhou University
2023-2024
Second Hospital of Shandong University
2022-2024
Union Hospital
2013-2023
University of South China
2022
To ascertain if preoperative short-term radiotherapy followed by chemotherapy is not inferior to a standard schedule of long-term chemoradiotherapy in patients with locally advanced rectal cancer.Patients distal or middle-third, clinical primary tumor stage 3-4 and/or regional lymph node-positive cancer were randomly assigned (1:1) (25 Gy five fractions over 1 week) four cycles (total neoadjuvant therapy [TNT]) (50 25 5 weeks, concurrently capecitabine [chemoradiotherapy; CRT]). Total...
A Se-containing heptamethine cyanine dye based fluorescent probe was successfully developed and used for HClO detection with rapid response high selectivity on aggregation behavior. The could react significant change in its fluorescence profile, which makes it practical detecting fetal bovine serum living mice.
Hydrazine is an important industrial chemical but also very toxic thus requiring rapid detection agents. A ratiometric fluorescence probe that enables rapid, low-limit and naked-eye successfully designed used for hydrazine determination in live cells.
LncRNAs have become a hot topic in various cancer-related researches. Radio-resistance is great threat for cancer therapy. However, how lncRNAs affect the radio-resistance cervical masked. As our paper, it was discovered that NEAT1 highly expressed tissues and non-sensitive as well radio-resistant cell lines. And overexpression of accelerated proliferation, while knockdown had opposite result. The effect on proliferation dependent dose ionizing radiation. silence also caused cycle arrest...
This study compared VMAT and IMRT plans for intact breast radiotherapy left sided cancer evaluated the irradiated dose of planning target volume OARs, especially focusing on heart coronary artery. Eleven patients with whose was relatively smaller (the mean volumes is 296 cc) treated breast-conserving surgery were prescribed 50 Gy in 25 fractions using two or four-field step shoot (2 4-F IMRT), one two-arc (1 2-arc VMAT). The 10 electron boost to tumor bed after delivery not included...
The neuropathology of the effects ethanol on developing central nervous system are similar to those patients with mutations in L1, a neural cell adhesion molecule. This observation suggests that inhibition L1 plays role pathogenesis alcohol-related neurodevelopmental disorders. Here we examine homophilic binding and L1-mediated neurite outgrowth. Ethanol had no effect or aggregation myeloma line expressing full-length human L1. In contrast, rate outgrowth rat postnatal day 6 cerebellar...
The well-known rhodamine spiro-lactam framework offers an ideal model for the development of fluorescence-enhanced chemosensors through simple and convenient syntheses. Herein, we report a new tridentate PNO receptor, which was introduced into system to develop Pd(2+)-chemosensor RPd4, that displayed significantly improved sensing properties palladium. Compound RPd4 shows very fast response time (about 5 s), high sensitivity (5 nM), excellent specificity Pd(2+) ions over other PGE (Pt(2+),...
Purpose: Cell death is one of the most important endpoints radiosensitivity. The tumor suppressor p53 participates not only in regulation apoptosis, but also autophagy mechanism. In this study, H1299-P53 (with wild-type p53) and H1299-175H mutant 175H) were used, effects on radiosensitivity analyzed. Methods: models with different status established by gene engineering, cell viability was examined colony formation assay, counting kit-8 (CCK-8), 3-Methyladenine, Z-VAD used to block...
3510 Background: It’s presented the results of a phase III trial short-term radiotherapy (SCRT) combined with chemotherapy versus long-term chemoradiotherapy (LCRT) in patients locally advanced rectal cancer (LARC). Methods: Patients distal or middle third, T3-T4 and/or N+ adenocarcinomas diagnosed by MRI, were randomly assigned to experimental group control group. In group, received SCRT (25 Gy / 5 fractions days), followed four courses CAPOX. LCRT (50 25 35 days concurrent capecitabine)....
The aim of this study was to analyse 19 recurrent keratocystic odontogenic tumours (KCOTs).19 patients with KCOTs were retrospectively analysed. These had been treated by either enucleation or a combination and Carnoy's solution. analyses covered major aspects primary KCOT and/or identities, including patient profile, clinical features, histopathology, radiology, treatment prognosis.19 (7.4%) out 257 cases recurred, an average age 30.5 years (age range 18-45 years). 15 lesions in the...
Colorectal cancer (CRC) is often resistant to conventional therapies. Previous studies have reported the anticancer effects of vitamin D in several cancers, its role radiotherapy (RT) remains unknown. We found that 1α, 25-dihydroxyvitamin 3 (VD ), biologically active form D, had antitumor effect on CRC and sensitized cells ionizing radiation (IR). VD demonstrated synergistic combination with IR, which were detected by colony formation cell proliferation assay. Radiosensitivity restoration...
A definitive optimal oncologic care regimen for recurrent multiple brain metastases (BMs) has yet to be established, and the accrual of high-quality evidence pertaining helical tomotherapy-based stereotactic radiotherapy (HT-SRT) in patients with BMs is needed. We treated a 64-year-old male smoker initially diagnosed non-small cell lung cancer (NSCLC) BMs, initial schedule involved administering linear accelerator-based hypofractionated (Linac-HSRT) targeting 6 intracranial lesions. Further...
Abstract Background Protein phosphatase 2 regulatory subunit A alpha ( PPP2R1A ) is the most common scaffold protein in PP2A complex and has known tumor-suppressive functions. However, its role gastric cancer (GC) still unclear. This study aims to elucidate potential of biological functions GC. Methods The mutation status expression levels GC were assessed through bioinformatics analysis, correlation between patient survival rates was examined, functional network analyzed. Stable AGS MGC803...
Self-assembly fluorescent vesicles were designed and prepared based on the supramolecular interaction of cyclodextrins N-alkylamino-l-anthraquinone (n-AQ). As guest molecules, n-AQs with alkyl lengths ranging from C0 to C18 synthesised by direct reaction alkylamine l-nitroanthraquinone in N,N-dimethylformamide. Transmission electron microscopy (TEM), scanning microscopy, dynamic light scattering epi fluorescence employed study vesicle system detail. The formation mechanism was suggested...
The role of Ataxia-telangiectasia mutated (ATM) in response to DNA damage has previously been studied, but its underlying mechanisms specific ionizing radiation (IR) have remained be elucidated. In this study, function ATM on radiation-induced cell death lung cancer H1299 cells was analysed.Human cells, H1299, were used, and models with ATM(-/-) MAPK14(-/-) established by genetic engineering. Radiosensitivity analysed using colony formation assays. Western blotting co-immunoprecipitation...
Objective: To evaluated the oncologic outcomes associated with platinum-based adjuvant chemotherapy following concurrent chemoradiotherapy (CCRT) in management of patients locally advanced cervical cancer (LACC). Methods: A total 695 FIGO stage IB2, IIA2, IIB-IVA LACC treated at 6 medical facilities were enrolled and divided into 2 groups: 478 assigned to CCRT alone (CCRT group) 217 after (CCRT-ACT group). The treatment retrospectively compared reported propensity score matching (PSM)...