A5100637076- Endometrial and Cervical Cancer Treatments
- Colorectal and Anal Carcinomas
- Maternal and fetal healthcare
- Cervical Cancer and HPV Research
- Maternal and Perinatal Health Interventions
- Management of metastatic bone disease
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Uterine Myomas and Treatments
- Pancreatic and Hepatic Oncology Research
- Pregnancy-related medical research
- Neuroblastoma Research and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Chronic Kidney Disease and Diabetes
- Microstructure and mechanical properties
- Liver Disease Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Luminescence Properties of Advanced Materials
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Radiomics and Machine Learning in Medical Imaging
- Animal Virus Infections Studies
- Ectopic Pregnancy Diagnosis and Management
- Cancer Research and Treatments
- Acute Kidney Injury Research
Peking University
2015-2025
Peking University Cancer Hospital
2015-2025
Chinese PLA General Hospital
2011-2025
Jinan University
2025
Qingdao Municipal Center for Disease Control and Prevention
2021-2025
Oregon Health & Science University
2022-2024
Hunan University
2021-2024
Circle Cardiovascular Imaging
2024
University of Science and Technology Beijing
2023-2024
State Council of the People's Republic of China
2024
The stomach is the main digestive organ in humans. Patients with gastric cancer often develop problems, which result poor nutrition. Nutritional status closely related to postoperative complications and quality of life (QoL) patients cancer. controlling nutritional (CONUT) score a novel tool evaluate patients. However, relationship CONUT complications, QoL, psychological has not been investigated. present follow-up study was conducted 106 who underwent radical gastrectomy our hospital...
Metastasis is a major challenge in breast cancer therapy. The successful chemotherapy of largely depends on the ability to block metastatic process. Herein, we designed dual-targeting and stimuli-responsive drug delivery system for targeted against metastasis.AS1411 aptamer-modified chondroitin sulfate A-ss-deoxycholic acid (ACSSD) was synthesized, unmodified CSSD used as control. Chemotherapeutic doxorubicin (DOX)-containing ACSSD (D-ACSSD) micelles were prepared by dialysis method....
Detection of exogenous p53 gene and target expression in cervical cancer cell lines SiHa C33A infected by recombinant adenovirus-p53 (rAd-p53) vitro. The rAd-p53 infection evidently increased the gene, p21 Bax gene. radiosensitization rates were 1.19 1.18 To evaluate effect safety transfer combined with radiotherapy (RT) patients cancer, (group PRT) 69 was compared a control group treated alone RT) 35 cancer. Patients intratumorally injected (1 × 1012 virus particles) once week for 6 weeks....
To assess the efficacy and safety of longitudinal parallel compression suture to control heavy postpartum hemorrhage (PPH) in patients with placenta previa/accreta.Fifteen women received a stop life-threatening PPH due previa or without accreta during cesarean section. The apposed anterior posterior walls lower uterine segment together using an absorbable thread A 70-mm round needle Number-1 was used. point entry 1 cm above upper margin cervix from right lateral border wall. threaded through...
Concurrent chemoradiotherapy (CCRT) involves the simultaneous administration of chemotherapy and radiotherapy, in which low-dose enhances effectiveness radiotherapy. This combined approach mitigates tumor recurrence metastasis, ultimately improving patient prognosis. The primary mechanism behind increased radiosensitivity induced by concurrent inhibiting cell repair complementary effects radiotherapy on different phases cycle. Despite CCRT application patients with locally advanced cervical...
5522 Background: Enlonstobart is a PD-1 inhibitor that has demonstrated durable anti-tumor activity and acceptable safety in patients with PD-L1 positive recurrent/metastatic cervical cancer multicenter, single-arm, open-label, phase II study. At primary cutoff date (May 27, 2023), the overall survival (OS) was not reached. Here, we report results from pre-planned further follow-up (August 20, 2024). Methods: Eligible were ≥18 years old PD-L1-positive (combined score ≥ 1) who had progression...
Anti-Thy1 nephritis is a well-established experimental mesangial proliferative model. Exploring the molecular mechanisms of pathophysiology in anti-Thy1 may elucidate pathogeneses proliferation. We examined roles and acting differentially expressed proteins (DEPs) by bioinformatics analysis glomeruli proteomic profiles during course nephritis. In total, 108 DEPs were found two-dimensional fluorescence difference gel electrophoresis (2D-DIGE), 40 identified matrix-assisted laser desorption...
To evaluate whether two-dose of varicella vaccine would provide a better protection to children from than one-dose, we conducted 1:3 matched case-control study in Qingdao, China. A total 509 cases aged 6-11 y were collected the China Information System for Disease Control and Prevention (CISDCP). And 1,527 controls, who did not suffer varicella, selected with by age class. The effectiveness (VE) corresponding 95% confidence interval (95% CI) calculated. vaccination coverage rate one-dose was...
5514 Background: Cervical cancer is the fourth common malignancy in women, with a 5-year overall survival rate of 24%-76.1%. At present, there are few studies on targeted drugs combined concurrent chemoradiotherapy (CCRT) for locally advanced cervical (LACC) and results were not satisfactory. This CC3 study first randomized, controlled, multicenter phase 3 trial EGFR CCRT cancer, aims to evaluate efficacy safety nimotuzumab (humanized EGFR) combination LACC. (NCT04678791). Methods: All...
5526 Background: Platinum-based chemotherapy with or without bevacizumab is the first-line treatment for patients recurrent metastatic cervical cancer, and options are limited cancer after treatment. Enlonstobart (SG001) a fully humanized high-affinity anti-PD-1 immunoglobulin G4 monoclonal antibody. Previous phase 1b study demonstrated that SG001 had promising efficacy in PD-L1 positive recurrent/metastatic cancer. Here we present safety results of II (ClinicalTrials. gov identifier:...
The benefit of adjuvant chemotherapy after definitive chemoradiotherapy in patients with pelvic lymph node-positive cervical cancer has been poorly studied. This study aimed to test the hypothesis that addition radiotherapy or concurrent improves survival squamous cell carcinoma.This retrospective enrolled stage IB-IVA carcinoma, without para-aortic node metastases and initially treated between March 2007 February 2018. Patients were classified into (5-fluorouracil paclitaxel, plus...
Objective: To evaluated the oncologic outcomes associated with platinum-based adjuvant chemotherapy following concurrent chemoradiotherapy (CCRT) in management of patients locally advanced cervical cancer (LACC). Methods: A total 695 FIGO stage IB2, IIA2, IIB-IVA LACC treated at 6 medical facilities were enrolled and divided into 2 groups: 478 assigned to CCRT alone (CCRT group) 217 after (CCRT-ACT group). The treatment retrospectively compared reported propensity score matching (PSM)...
Abstract Consider a three-dimensional vortex sheet in inviscid, incompressible flow which is irrotational away from the sheet. We derive an equation for evolution of Lagrangian coordinates, i.e. that restricted to itself and analogous Birkhoff-Rott two-dimensional (planar) This general specialized sheets with axial or helical symmetry, without swirl.
Arahypin-16 (1), a new prenylated resveratrol with unique dihydrobenzofuran ring, has been isolated as microbial metabolite of (2) from whole-cell fermentation Aspergillus sp. SCSIOW2. The stereochemistry 1 was determined by ECD calculations. showed about half the extracellular radical scavenging effect (IC50 = 161.4 μM) compared 80.5 μM), while on biomembranes it exhibited same range protection effects against free radicals generated AAPH 78.6 μM and 87.9 μM).
To identify factors associated with receipt of incomplete cisplatin during chemoradiation for locally advanced cervical cancer and its impact on outcomes.Patients treated at our institution between November 2015 August 2020 were retrospectively identified. Patients who received ≤4 cycles identified as the 'incomplete' cohort those 5-6 'complete' cohort. The primary endpoint chemotherapy was evaluated multivariable logistic regression. Secondary endpoints locoregional failure, overall...
Although radiotherapy following mastectomy was demonstrated to reduce the recurring risk and improve prognosis of patients with breast cancer, it is also notorious for comprehensive side effects, hence only a selected group can benefit. Therefore, screening molecular markers capable predicting efficacy essential. We have established cohort 454 cancer cases 238 indications postoperative radiotherapy. Synuclein-γ (SNCG) protein levels were assessed by immunohistochemistry, SNCG status...
A characteristic region with vacancy concentration ranging from 0% to 2% was introduced into the single-crystal iron investigate effects of vacancies on plasticity and phase transformation under shock loading. The simulations were implemented by applying non-equilibrium molecular dynamics an excellent modified analytic embedded-atom method (MAEAM) potential. fixed piston velocity vp = 0.5 km/s applied in our simulations, which no or occurred perfect based description used MAEAM observably...
Abstract Background Cirrhosis patients often exhibit clinical symptoms such as right liver atrophy, portal hypertension, spleen enlargement and increased blood supply, which considerable variation between the left sections. These differences are hypothesized to stem from disparities in flow within vein (PV) branches. However, rigorous quantitative evidence remains scarce. Purpose We mainly aim at quantitatively revealing relationship rates of two PV branches volumes, providing theoretical...