A5044870790- Endometrial and Cervical Cancer Treatments
- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Cervical Cancer and HPV Research
- Colorectal and Anal Carcinomas
- Management of metastatic bone disease
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Ovarian cancer diagnosis and treatment
- Advances in Oncology and Radiotherapy
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods in Clinical Trials
- Breast Cancer Treatment Studies
- Glioma Diagnosis and Treatment
- Radiation Dose and Imaging
- Head and Neck Surgical Oncology
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Economic and Financial Impacts of Cancer
- Advanced Causal Inference Techniques
- Cancer survivorship and care
- Effects of Radiation Exposure
University of California, San Diego
2016-2025
Moores Cancer Center
2014-2025
UC San Diego Health System
2014-2025
Precision for Medicine (United States)
2018-2023
University of San Diego
2022
University of California San Diego Medical Center
2009-2021
NRG Oncology
2018
Stanford University
2013-2016
Peking University
2015-2016
Case Western Reserve University
2016
Treatment is complex for patients with head and neck (H&N) cancers specific site of disease, stage, pathologic findings guiding treatment decision-making. planning H&N involves a multidisciplinary team experts. This article describes supportive care recommendations in the NCCN Guidelines Head Neck Cancers, as well rationale supporting new section on imaging cancers. also updates to very advanced salivary gland tumors, specifically systemic therapy recommendations.
Head and neck cancers, including those of the lip oral cavity, nasal paranasal sinuses, oropharynx, larynx nasopharynx represent nearly 700,000 new cases 380,000 deaths worldwide per annum, account for over 10,000 annual in United States alone. Improvement outcomes are needed patients with recurrent or metastatic squamous cell carcinoma head (HNSCC). In 2016, US Food Drug Administration (FDA) granted first immunotherapeutic approvals - anti-PD-1 immune checkpoint inhibitors nivolumab...
<section class="abstract"><p id="P1">The NCCN Guidelines for Head and Neck (H&N) Cancers provide treatment recommendations cancers of the lip, oral cavity, pharynx, larynx, ethmoid maxillary sinuses, salivary glands. Recommendations are also provided occult primary H&N, separate algorithms have been developed by panel very advanced H&N cancers. These Insights summarize panel's discussion most recent regarding evaluation nasopharyngeal carcinoma. </section>
PURPOSE Death from noncancer causes (competing mortality) is an important event in head and neck cancer, but studies identifying predictors of this are lacking. We sought to identify competing mortality develop a risk stratification model for events. PATIENTS AND METHODS Cohort study 479 patients with stage III IV carcinoma the diagnosed between August 1993 November 2004. Patients were treated on consecutive prospective clinical trials involving organ-preserving chemoradiotherapy surgery....
Context. The benefits of continuity pediatric care remain controversial. Objective. To determine whether there is an association between having a continuous relationship with primary provider and decreased risk emergency department (ED) visitation hospitalization. Design. Retrospective cohort study. Setting Population. We used claims data from 46 097 patients enrolled at Group Health Cooperative, large staff-model health maintenance organization, January 1, 1993, December 31, 1998, for our...
The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity (including mucosal lip), pharynx, larynx, paranasal sinuses. Occult primary cancer, salivary gland melanoma (MM) are also addressed. specific site of disease, stage, pathologic findings guide treatment (eg, appropriate surgical procedure, radiation targets, dose fractionation radiation, indications systemic therapy). Panel meets at least annually to review comments from reviewers within their...
The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck Cancers provide treatment recommendations cancers of the lip, oral cavity, pharynx, larynx, ethmoid maxillary sinuses, salivary glands. Recommendations are also provided occult primary head neck (H&N), separate algorithms have been developed by panel very advanced H&N cancers. These Insights summarize panel's discussion most recent regarding increase human papillomavirus–associated oropharyngeal cancer...
Reducing radiation treatment dose could improve the quality of life (QOL) patients with good-risk human papillomavirus-associated oropharyngeal squamous cell carcinoma (OPSCC). Whether reduced-dose produces disease control and QOL equivalent to standard chemoradiation is not proven.In this randomized, phase II trial, p16-positive, T1-T2 N1-N2b M0, or T3 N0-N2b M0 OPSCC (7th edition staging) ≤ 10 pack-years smoking received 60 Gy intensity-modulated therapy (IMRT) over 6 weeks concurrent...
This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Head and Neck Cancers focuses on glottic laryngeal cancer, which is most common type of cancer has an excellent cure rate. The lymphatic drainage glottis sparse, early stage primaries rarely spread to regional nodes. Because hoarseness symptom, at diagnosis. Updates these guidelines 2014 include revisions "Principles Radiation Therapy" each site Surgery," addition a new section Dental Evaluation Management."
These NCCN Guidelines Insights focus on recent updates to the 2015 for Head and Neck (H&N) Cancers. describe different types of particle therapy that may be used treat H&N cancers, in contrast traditional radiation (RT) with photons (x-ray). Research is ongoing regarding therapy, including protons carbon ions, goals reducing long-term side effects from RT improving therapeutic index. For update, Cancers Panel agreed delete recommendations neutron salivary gland because its limited...
Abstract BACKGROUND: Stereotactic body radiotherapy (SBRT) is a technique used to deliver high, ablative doses of radiation in limited number fractions ≥1 extracranial target(s). To the authors' knowledge, prevalence SBRT use among oncologists United States unknown. METHODS: A random sample 1600 American was surveyed via e‐mail and facsimile (fax) regarding usage, including year adoption, motivations, disease sites treated, common prescriptions used. RESULTS: Of 1373 contactable physicians,...
Abstract Purpose: To characterize the role of B cells on human papilloma virus (HPV)-associated cancer patient outcomes and determine effects radiation PD-1 blockade B-cell populations. Experimental Design: Tumor RNA-sequencing data from over 800 patients with head neck squamous cell carcinoma (HNSCC) cervical cancer, including a prospective validation cohort, was analyzed to study impact gene expression overall survival (OS). A novel murine model HPV+ HNSCC used radiotherapy activation,...
Spine metastasis can be treated with high-dose radiation therapy advanced delivery technology for long-term tumor and pain control.
The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity (including mucosal lip), pharynx, larynx, paranasal sinuses, as well occult primary cancer, salivary gland melanoma (MM). specific site of disease, stage, pathologic findings guide treatment (eg, appropriate surgical procedure, radiation targets, dose fractionation radiation, indications systemic therapy). Panel meets at least annually to review comments from reviewers within their institutions, examine...
PURPOSE Radiotherapy (RT)/cetuximab (C) demonstrated superiority over RT alone for locally advanced squamous head and neck cancer. We tested this in completely resected, intermediate-risk METHODS Patients had cell carcinoma of the (SCCHN) oral cavity, oropharynx, or larynx, with one more risk factors warranting postoperative RT. were randomly assigned 1:1 to intensity-modulated (60-66 Gy) once-per-week C alone. The primary hypothesis was that + would improve overall survival (OS)...
To report a multicenter experience treating anal canal cancer patients with concurrent chemotherapy and intensity-modulated radiation therapy (IMRT).From October 2000 to June 2006, 53 were treated IMRT for squamous cell carcinoma at three tertiary-care academic medical centers. Sixty-two percent T1-2, 67% N0; eight HIV positive. Forty-eight received fluorouracil (FU)/mitomycin, one FU/cisplatin, four FU alone. All underwent computed tomography-based treatment planning pelvic regions inguinal...
Objective. Reports have suggested that streptococcal infection may be etiologically related to pediatric autoimmune neuropsychiatric disorders (PANDAS), but there are few good epidemiologic studies support this theory. Using population-based data from a large West-Coast health maintenance organization, we assessed whether was associated with increased risk for obsessive-compulsive disorder (OCD), Tourette's syndrome (TS), or tic disorder. Methods. This is case-control study of children 4 13...
Background. Despite an increasing prevalence of diagnosed attention-deficit/hyperactivity disorder (ADHD) among children, the impact ADHD on utilization and costs health care services is largely unknown. Objective. To examine differences in between children with without ADHD. Design. Retrospective matched cohort study conducted from January 1 to December 31, 1997. Setting. Health maintenance organization western Washington State. Participants. Children aged 3 through 17 years who were...
Intensity-modulated radiation therapy (IMRT) is a novel approach to the planning and delivery of therapy. The prevalence IMRT use among oncologists in U.S. appears be increasing, despite limited data evaluating its risks benefits.A random sample U.S., including cohort 441 physicians who were surveyed 2002, was regarding use. users questioned their frequency use, clinical applications, reasons for adopting IMRT. nonusers asked not using IMRT, whether they planned it future, wanting adopt...