Karen Lim

ORCID: 0000-0002-4861-2108
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About
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Research Areas
  • Advanced Radiotherapy Techniques
  • Endometrial and Cervical Cancer Treatments
  • Radiomics and Machine Learning in Medical Imaging
  • MRI in cancer diagnosis
  • Cervical Cancer and HPV Research
  • Management of metastatic bone disease
  • Breast Cancer Treatment Studies
  • Medical Imaging and Analysis
  • Prostate Cancer Diagnosis and Treatment
  • Medical Image Segmentation Techniques
  • Lung Cancer Diagnosis and Treatment
  • Radiation Dose and Imaging
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Advances in Oncology and Radiotherapy
  • Prostate Cancer Treatment and Research
  • Radiation Therapy and Dosimetry
  • Medical Imaging Techniques and Applications
  • Ovarian cancer diagnosis and treatment
  • Antimicrobial Resistance in Staphylococcus
  • Colorectal and Anal Carcinomas
  • Bacterial Identification and Susceptibility Testing
  • Fractal and DNA sequence analysis
  • Head and Neck Cancer Studies
  • Sodium Intake and Health
  • Frailty in Older Adults

Liverpool Hospital
2013-2024

Cancer Australia
2019-2024

Ng Teng Fong General Hospital
2024

National University Health System
2013-2024

Redcliffe Hospital
2023

South Western Sydney Local Health District
2016-2022

UNSW Sydney
2012-2022

Ingham Institute
2015-2022

Western Sydney University
2014

University Health Network
2007-2012

Abstract Background Persistent Staphylococcus aureus bacteremia is associated with metastatic infection and adverse outcomes, whereas gram-negative normally transient shorter course therapy increasingly advocated for affected patients. Whether the prolonged detection of pathogen DNA in blood by culture-independent systems could have prognostic value guide management decisions unknown. Methods We performed a multicenter, prospective, observational study on 102 patients bloodstream (BSI) to...

10.1093/cid/ciad663 article EN cc-by-nc-nd Clinical Infectious Diseases 2023-10-27

Abstract Introduction This study quantified inter‐observer contouring variations for multiple male pelvic structures, many of which are emerging relevance prostate cancer radiotherapy progression and toxicity response studies. Methods Five patient datasets ( CT T2‐weighted MR ) were distributed to 13 observers contouring. structures contoured included the clinical target volume CTV ), seminal vesicles, rectum, colon, bowel bag, bladder peri‐rectal space PRS ). contours , trigone, membranous...

10.1111/1754-9485.12844 article EN Journal of Medical Imaging and Radiation Oncology 2019-01-04

Approximately 50% of cancer survivors experience moderate-severe fear recurrence (FCR). Self-guided digital interventions have potential to address the high level FCR-related unmet needs at scale, but existing demonstrated variable engagement and efficacy. This study aimed evaluate feasibility preliminary efficacy iConquerFear, a five-module self-guided FCR intervention. Eligible curatively treated breast were recruited. Participants reporting clinically significant (≥ 13 on Fear Cancer...

10.1007/s11764-022-01233-9 article EN cc-by Journal of Cancer Survivorship 2022-07-25

Stereotactic ablative body radiotherapy is used in prostate cancer to deliver a high dose of radiation the tumour over small number treatments. This involves simulation patient using both CT and MRI. Current practice insert an indwelling catheter (IDC) during assist with visualisation urethra subsequently minimise this highly critical structure. However, procedure invasive has associated risk infection. case study, which demonstrates our initial experience real-time non-invasive MRI...

10.1088/1361-6560/62/8/3003 article EN Physics in Medicine and Biology 2017-03-17

Abstract Introduction Magnetic resonance imaging ( MRI ) is increasingly used for target volume delineation in radiotherapy due to its superior soft tissue visualisation compared computed tomography CT ). The aim of this study was assess the impact a radiologist‐led workshop on inter‐observer variability . Methods Data from three separate studies evaluating lung, breast and cervix were collated. At pre‐workshop evaluation, observers involved each clinical site instructed delineate specified...

10.1002/jmrs.298 article EN cc-by Journal of Medical Radiation Sciences 2018-08-03

A prompt diagnosis of bacteraemia and sepsis is essential. Markers to predict the risk persistent metastatic infection are lacking. SeptiCyte RAPID a host response assay stratifying patients according infectious vs sterile inflammation through scoring system (SeptiScore). In this study we explore association between SeptiScore as well in context proven episode.

10.1080/23744235.2023.2294122 article EN Infectious Diseases 2023-12-13

Abstract This study aimed to identify potential anatomical variation triggers using magnetic resonance imaging for plan adaption of cervical cancer patients ensure dose requirements were met over an external beam radiotherapy course. Magnetic images (MRIs) acquired before and during treatment rigidly registered a pre-treatment computerised tomography (CT) image 11 retrospective cervix datasets. Target volumes (TVs) organs at risk (OARs) delineated on both MRIs propagated onto the CT....

10.1007/s13246-024-01473-2 article EN cc-by Physical and Engineering Sciences in Medicine 2024-08-08

Abstract Introduction The purpose of this survey was to explore the current patterns practice for brachytherapy in cervix cancer Australia and New Zealand. also intended clinician attitudes towards image‐guided adaptive ( IGABT ) identify barriers implementation . Methods Electronic surveys were sent all radiotherapy centres Zealand under collaboration with Gynaecology Oncology Group ANZGOG ), order practice. out December 2013, a reminder February 2014. Results Of 75 Zealand, 23 replied (31%...

10.1111/1754-9485.12614 article EN Journal of Medical Imaging and Radiation Oncology 2017-05-04

Abstract Introduction Magnetic Resonance Imaging ( MRI ) provides excellent soft tissue definition of pelvic tumours and organs. The aim this study was to quantify differences in delineated clinical target volumes CTV s) between computed tomography CT . Methods Twenty patients with locally advanced gynaecological malignancies were recruited. Patients underwent dedicated simulation following simulation. Four clinicians independently contoured each structures using the Radiation Therapy...

10.1111/1754-9485.12831 article EN Journal of Medical Imaging and Radiation Oncology 2018-12-03

Cervical cancer is a common in women globally, with treatment usually involving radiation therapy (RT). Accurate segmentation for the tumour site and organ-at-risks (OARs) could assist reduction of side effects improve planning efficiency. Magnetic Resonance Imaging (MRI) challenging due to limited amount training data available large inter- intra- patient shape variation OARs. The proposed Masked-Net consists masked encoder within 3D U-Net account dataset, additional dilated layers added...

10.1007/s13246-024-01415-y article EN cc-by Physical and Engineering Sciences in Medicine 2024-04-24
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