A5064900626- Endometrial and Cervical Cancer Treatments
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- MRI in cancer diagnosis
- Prostate Cancer Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Advances in Oncology and Radiotherapy
- Cervical Cancer and HPV Research
- Management of metastatic bone disease
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- Artificial Intelligence in Healthcare and Education
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Metabolism, Diabetes, and Cancer
- Sarcoma Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Urinary and Genital Oncology Studies
- Glioma Diagnosis and Treatment
- Angiogenesis and VEGF in Cancer
- Head and Neck Cancer Studies
- Radiation Therapy and Dosimetry
University of Toronto
2015-2024
Princess Margaret Cancer Centre
2015-2024
University Health Network
2015-2024
Canada Research Chairs
2019
Henry Ford Health System
2019
Radiation Oncology Associates
2003-2019
Gynecologic Oncology Group
1998-2019
Health Net
2008-2018
Health Sciences Centre
2011-2018
International Atomic Energy Agency
2016
BackgroundClinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indices in cancer improve risk stratification complement clinical factors.MethodsWe used DNA-based alone combination intra-prostatic hypoxia measurements develop four 126 low-risk intermediate-risk (Toronto cohort) who will receive radiotherapy. validated these...
Tumor hypoxia is a negative prognostic factor in multiple cancers, due part to its role causing resistance radiotherapy. Hypoxia arises tumor regions distal blood vessels as oxygen consumed by more proximal cells. Reducing the rate of consumption therefore potential strategy reduce hypoxia. We hypothesized that anti-diabetic drug metformin, which reduces through inhibition mitochondrial complex I, would improve radiation response increasing oxygenation.Tumor was measured xenografts before...
Refinement of radiomic results and methodologies is required to ensure progression the field. In this work, we establish a set safeguards designed improve support current through detailed analysis signature.A model (MW2018) was fitted externally validated using features extracted from previously reported lung head neck (H&N) cancer datasets gross-tumour-volume contours, as well images with randomly permuted voxel index values; i.e. without meaningful texture. To determine MW2018's added...
Purpose Multidisciplinary management improves complex treatment decision making in cancer care, but its impact for bladder (BC) has not been documented. Although radical cystectomy (RC) currently is viewed as the standard of care muscle-invasive (MIBC), radiotherapy-based, bladder-sparing trimodal therapy (TMT) that combines transurethral resection tumor, chemotherapy radiation sensitization, and external beam radiotherapy emerged a valid option. In absence randomized studies, this study...
Abstract Purpose: Tumor hypoxia is an important determinant of outcome in many human malignancies and associated with treatment resistance metastases. The aim this study was to determine the effect patients prostate cancer treated radiotherapy. Experimental Design: measured 247 clinically localized before radiotherapy, or without hormonal therapy. median pO2 6.8 mm Hg hypoxic percentage less than 10 (HP10) 63%. follow-up 6.6 years. Results: 5-year biochemical relapse-free rate (bRFR) 78%....
PURPOSE: This prospective clinical study was begun in 1994 to validate the independent prognostic impact of tumor hypoxia patients with cervix cancer treated definitive radiation therapy. PATIENTS AND METHODS: Between May and January 1999, 106 eligible epithelial had oxygen pressure (PO 2 ) measured using Eppendorf probe. Oxygenation data are presented as hypoxic proportion, defined percentage PO readings less than 5 mm/Hg (abbreviated HP median . RESULTS: The individual 48%,...
The objective of this study was to investigate the prognostic value pretreatment circulating neutrophil count (CNC), monocyte (CMC), and lymphocyte (CLC) in human papillomavirus (HPV)-related (HPV+) HPV-unrelated (HPV-) oropharyngeal cancer (OPC).All p16-confirmed HPV+ HPV- OPC cases treated with chemoradiotherapy from 2000 2010 were included. Overall survival (OS) recurrence-free (RFS) compared for high low CNCs, CMCs, CLCs (dichotomized by median values). A multivariate analysis (MVA)...
Caveolin-1 (CAV1) is an essential structural constituent of caveolae, specialized lipid raft microdomains on the cell membrane involved in endocytosis and signal transduction, which are inexplicably deregulated associated with aggressiveness numerous cancers. Here we identify CAV1 as a direct transcriptional target oxygen-labile hypoxia-inducible factor 1 2 that accentuates formation leading to increased dimerization EGF receptor within confined surface area caveolae its subsequent...
Abstract Despite the use of PSA, Gleason score, and T‐category as prognosticators in intermediate‐risk prostate cancer, 20–40% patients will fail local therapy. In order to optimize treatment approaches for patients, additional genetic are needed. Previous reports using array comparative genomic hybridization (aCGH) radical prostatectomy cohorts suggested a combination allelic loss PTEN gene on 10q gain c‐MYC 8q were associated with metastatic disease. We tested whether copy number...