A5032753703- Head and Neck Cancer Studies
- Advanced Radiotherapy Techniques
- Cancer survivorship and care
- Gastric Cancer Management and Outcomes
- Head and Neck Surgical Oncology
- Lung Cancer Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Management of metastatic bone disease
- Salivary Gland Tumors Diagnosis and Treatment
- Oral health in cancer treatment
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Brain Metastases and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Advances in Oncology and Radiotherapy
- Health Systems, Economic Evaluations, Quality of Life
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Dysphagia Assessment and Management
- Palliative Care and End-of-Life Issues
- Economic and Financial Impacts of Cancer
- Colorectal Cancer Treatments and Studies
- Esophageal and GI Pathology
Princess Margaret Cancer Centre
2016-2025
University of Toronto
2016-2025
University Health Network
2016-2025
Queen's University
2013-2025
Columbia University
2020
Fistula Foundation
2020
Université de Montréal
2020
CHU Dinant Godinne UCL Namur
2019
Washington University in St. Louis
2019
Centre Hospitalier de l’Université de Montréal
2017
Purpose To describe outcomes of prospective trials stereotactic body radiotherapy (SBRT) for hepatocellular carcinoma (HCC). Patients and Methods Two SBRT patients with active HCC unsuitable standard locoregional therapies were conducted from 2004 to 2010. All had Child-Turcotte-Pugh class A disease, at least 700 mL non-HCC liver. The dose range was 24 54 Gy in six fractions. Primary end points toxicity local control 1 year (LC1y), defined as no progressive disease (PD) irradiated by RECIST...
To define human papillomavirus (HPV) -positive oropharyngeal cancers (OPC) suitable for treatment deintensification according to low risk of distant metastasis (DM).OPC treated with radiotherapy (RT) or chemoradiotherapy (CRT) from 2001 2009 were included. Outcomes compared HPV-positive versus HPV-negative patients. Univariate and multivariate analyses identified outcome predictors. Recursive partitioning analysis (RPA) stratified the DM risk.HPV status was ascertained in 505 (56%) 899...
To report on the outcomes of a phase I study stereotactic body radiotherapy (SBRT) for treatment liver metastases.Patients with metastases that were inoperable or medically unsuitable resection, and who not candidates standard therapies, eligible this individualized SBRT. Individualized radiation doses chosen to maintain same nominal risk radiation-induced disease (RILD) three estimated levels (5%, 10%, 20%). Additional patients treated at maximal dose (MSD) in an expanded cohort. Median...
Purpose To refine stage and prognostic group for human papillomavirus (HPV) –related nonmetastatic (M0) oropharyngeal cancer (OPC). Methods All patients with p16-confirmed OPC treated radiotherapy or without chemotherapy from 2000 to 2010 were included. Overall survival (OS) was compared among TNM stages HPV-related HPV-unrelated separately. For OPC, recursive partitioning analysis (RPA) derived new RPA objectively. Cox regression used calculate adjusted hazard ratios (AHRs) derive AHR...
Purpose Promising results in a randomized phase II trial with the hypoxic cytotoxin tirapazamine (TPZ) combined cisplatin (CIS) and radiation led to this III trial. Patients Methods previously untreated stage or IV (excluding T1-2N1 M1) squamous cell carcinoma of oral cavity, oropharynx, hypopharynx, larynx were randomly assigned receive definitive radiotherapy (70 Gy 7 weeks) concurrently either CIS (100 mg/m 2 ) on day 1 weeks 1, 4, (75 plus TPZ (290 /d) alone (160 days 3, 5 3 (TPZ/CIS)....
A significant proportion of oropharyngeal squamous cell carcinomas (OSCC) are associated with the human papilloma virus (HPV), particularly HPV16. The optimal method for HPV determination on archival materials however, remains unclear. We compared a quantitative real-time polymerase chain reaction (qRT-PCR) assay HPV16 mRNA to DNA in situ hybridization (ISH) method, and evaluated their significance overall (OS) disease-free (DFS) survival.Matched, biopsies from 111 patients OSCC were using...
The goal of this study was to determine what magnitude change in a patient-reported outcome score is clinically meaningful, so clinicians' guide may be provided for estimating the minimal important difference (MID) when empiric estimates are not available.Consecutive laryngeal cancer patients (n = 98) rated their quality life (QOL) relative other patients. These comparisons were contrasted with arithmetic differences scores on Functional Assessment Cancer Therapy-Head and Neck (FACT-H&N)...
The National Cancer Institute’s Common Terminology Criteria for Adverse Events (NCI-CTCAE) reporting system is widely used by clinicians to measure patient symptoms in clinical trials. European Organization Research and Treatment of Cancer's Quality Life core questionnaire (EORTC QLQ-C30) enables cancer patients rate their related quality life. We examined the extent which clinician symptom scoring agreement could contribute estimation overall survival among patients. analyzed baseline data...
BACKGROUND The objective of this study was to examine the prognostic value baseline health‐related quality life (HRQOL) for survival with regard different cancer sites using 1 standardized and validated patient self‐assessment tool. METHODS In total, 11 pooled from 30 European Organization Research Treatment Cancer (EORTC) randomized controlled trials were selected study. For each site, univariate multivariate Cox proportional hazards modeling used assess ( P < .05) 15 HRQOL parameters...
The objective of this study was to investigate the prognostic value pretreatment circulating neutrophil count (CNC), monocyte (CMC), and lymphocyte (CLC) in human papillomavirus (HPV)-related (HPV+) HPV-unrelated (HPV-) oropharyngeal cancer (OPC).All p16-confirmed HPV+ HPV- OPC cases treated with chemoradiotherapy from 2000 2010 were included. Overall survival (OS) recurrence-free (RFS) compared for high low CNCs, CMCs, CLCs (dichotomized by median values). A multivariate analysis (MVA)...
Osteoradionecrosis (ORN) of the mandible is a late toxicity affecting patients treated with radiotherapy for head and neck malignancies. To authors' knowledge, ORN has no standardized grading system its reporting based on retrospective findings in heterogeneous patient populations. The rate era intensity-modulated (IMRT) still unknown.The authors report incidence from prospectively collected data regarding 1196 who were diagnosed squamous cell carcinoma oropharynx curative-intent IMRT, or...