A5047039369- Head and Neck Cancer Studies
- Chromatin Remodeling and Cancer
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- RNA modifications and cancer
- Cancer Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Head and Neck Surgical Oncology
- Reconstructive Surgery and Microvascular Techniques
- Ear and Head Tumors
- Photodynamic Therapy Research Studies
- Cancer-related molecular mechanisms research
- Nanoplatforms for cancer theranostics
- Spectroscopy Techniques in Biomedical and Chemical Research
- CRISPR and Genetic Engineering
- Cancer-related gene regulation
- Sarcoma Diagnosis and Treatment
- Otitis Media and Relapsing Polychondritis
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Bone Tumor Diagnosis and Treatments
- Oral Health Pathology and Treatment
University of California, Davis
2019-2025
UC Davis Comprehensive Cancer Center
2022-2025
University of Michigan
2015-2024
University of California Davis Medical Center
2022-2024
UC Davis Health System
2021-2024
Stanford University
2018-2020
Michigan Medicine
2014-2019
Stanford Medicine
2019
Michigan Center for Translational Pathology
2016-2018
Michigan United
2016-2018
The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity (including mucosal lip), pharynx, larynx, paranasal sinuses. Occult primary cancer, salivary gland melanoma (MM) are also addressed. specific site of disease, stage, pathologic findings guide treatment (eg, appropriate surgical procedure, radiation targets, dose fractionation radiation, indications systemic therapy). Panel meets at least annually to review comments from reviewers within their...
The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity (including mucosal lip), pharynx, larynx, paranasal sinuses, as well occult primary cancer, salivary gland melanoma (MM). specific site of disease, stage, pathologic findings guide treatment (eg, appropriate surgical procedure, radiation targets, dose fractionation radiation, indications systemic therapy). Panel meets at least annually to review comments from reviewers within their institutions, examine...
Recent genome-wide association studies have identified a genetic locus at human chromosome 8q24 as having minor alleles associated with lower levels of plasma triglyceride (TG) and LDL cholesterol (LDL-C), higher HDL-C, well decreased risk for myocardial infarction. This contains only one annotated gene, tribbles homolog 1 (TRIB1), which has not previously been implicated in lipoprotein metabolism. Here we demonstrate role Trib1 regulator metabolism mice. Hepatic-specific overexpression...
Although surgical resection has been the primary treatment modality of solid tumors for decades, surgeons still rely on visual cues and palpation to delineate healthy from cancerous tissue. This may contribute high rate (up 30%) positive margins in head neck cancer resections. Margin status these patients is most important prognostic factor overall survival. In addition, second lesions be present at time surgery. often unnoticed by medical team, can have significant survival ramifications....
Abstract Purpose: Despite major advancements in surgical oncology, the positive margin rate for primary head and neck cancer resection remains around 15%–30%. In particular, deep surface is most challenging to adequately assess. Inadequate margins are directly correlated poor survival, as such, mitigation of these rates critical improve patient outcomes. We have developed an ex vivo imaging strategy that utilizes fluorescence intensity peaks (relative background signal) injected anti-EGFR...
Objective: To demonstrate the diagnostic ability of label-free, point-scanning, fiber-based Fluorescence Lifetime Imaging (FLIm) as a means intraoperative guidance during oral and oropharyngeal cancer removal surgery. Methods: FLIm point-measurements acquired from 53 patients (n = 67893 pre-resection in vivo, n 89695 post-resection ex vivo) undergoing or surgery were used for analysis. Discrimination healthy tissue was investigated using various FLIm-derived parameter sets classifiers...
Given the emerging diagnostic utility of extracellular vesicles (EVs), it is important to account for non-EV contaminants. Lipoprotein present in EV-enriched isolates may inflate particle counts and decrease sensitivity biomarkers interest, skewing chemical analyses perpetuating downstream issues labeling or functional analysis. Using label free surface enhanced Raman scattering (SERS), we confirm that three common EV isolation methods (differential ultracentrifugation, density gradient size...
Objectives To describe the impact that coronavirus disease 2019 (COVID‐19) pandemic had on presentation of patients with head and neck cancer in a single tertiary care center. Study Design Retrospective cohort study. Setting Academic institution. Methods We performed retrospective review newly diagnosed squamous cell carcinoma (HNSCC) who presented as new between September 10, 2019, 11, 2020. Patients presenting during 6 months leading up to announcement (pre–COVID‐19 period) March 2020,...
The indications for neck dissection concurrent with salvage laryngectomy in the clinically N0 setting remain unclear. Our goals were to determine prevalence of occult nodal disease, analyze disease distribution patterns, and identify predictors a cohort.Case series planned data collection.Tertiary academic center.Patients persistent or recurrent laryngeal squamous cell carcinoma (LSCC) after radiation/chemoradiation failure undergoing dissection.We analyzed single-institution retrospective...
Abstract As a rapid, label-free, non-destructive analytical measurement requiring little to no sample preparation, Raman spectroscopy shows great promise for liquid biopsy cancer detection and diagnosis. We carried out analysis mass spectrometry of plasma saliva from more than 50 subjects in cohort head neck patients benign controls (e.g., with oral masses). Unsupervised data models were built assess diagnostic performance. spectra collected either biofluid provided moderate performance...
<h3>Objective</h3>To describe the complications and adverse effects of postoperative radiotherapy in patients with Fanconi anemia (FA).<h3>Design</h3>Cohort study.<h3>Setting</h3>Patients FA treated at community tertiary care hospitals throughout United States.<h3>Patients</h3>The study included who were enrolled International Registry (IFAR) developed head neck squamous cell carcinoma received radiotherapy.<h3>Main Outcome Measures</h3>Demographics dosages...
Total laryngectomy remains the treatment of choice for recurrent/persistent laryngeal squamous cell carcinoma (SCC) after radiotherapy (RT) or chemoradiotherapy (CRT). However, despite attempts at aggressive surgical salvage, survival in this cohort suboptimal.A prospectively maintained single-institution database was queried patients undergoing total SCC initial RT/CRT between 1998 and 2015(n = 244). Demographic, clinical, data were abstracted. The Kaplan-Meier curves hazard ratios (HRs)...
While sequencing studies have provided an improved understanding of the genetic landscape head and neck squamous cell carcinomas (HNSCC), there remains a significant lack data derived from non-Caucasian cohorts. Additionally, is wide variation in HNSCC incidence mortality worldwide both between within various geographic regions. These epidemiologic differences are part accounted for by varying exposure to environmental risk factors such as tobacco, alcohol, high human papilloma viruses betel...
ERBB2 (formerly HER2) is an important drug target in breast cancer, where anti-ERBB2 therapy has been shown to lead improvements disease recurrence and overall survival. status head neck squamous cell carcinoma (HNSCC) not well studied. Identification of ERBB2-positive tumors characterization response could targeted treatment options HNSCC.To identify aberrations HNSCCs investigate the potential for ERBB2-targeted HNSCCs.A retrospective case series patients with laryngeal (42 tumor...
Objective: Complete surgical resection is the standard of care for treatment oral cancer although positive margin rate remains 15-30%. Tissue sampling from resected specimen and wound bed frozen section analysis (FSA) mainstay intraoperative assessment but subject to error can require processing multiple samples. We sought understand if an ex vivo imaging strategy using a tumor-targeted fluorescently labeled antibody could accurately identify closest peripheral on mucosal surface tumor...
This study evaluated whether fluorescence lifetime imaging (FLIm), coupled with standard diagnostic workups, could enhance primary lesion detection in patients p16+ head and neck squamous cell carcinoma of the unknown (HNSCCUP).FLIm was integrated into transoral robotic surgery to acquire optical data on six HNSCCUP patients' oropharyngeal tissues. An additional 55-patient FLIm dataset, comprising conventional tumors, trained a machine learning classifier; output predicted presence location...