Detection of exogenous p53 gene and target expression in cervical cancer cell lines SiHa C33A infected by recombinant adenovirus-p53 (rAd-p53) vitro. The rAd-p53 infection evidently increased the gene, p21 Bax gene. radiosensitization rates were 1.19 1.18 To evaluate effect safety transfer combined with radiotherapy (RT) patients cancer, (group PRT) 69 was compared a control group treated alone RT) 35 cancer. Patients intratumorally injected (1 × 1012 virus particles) once week for 6 weeks....

Preoperative denosumab has been an essential part of the management giant cell tumor bone (GCTB) which enhanced subchondral integrity and facilitated joint preservation surgery. However, evidence suggests that denosumab-induced sclerotic changes may potentially increase risk postoperative recurrence. This study evaluates efficacy microwave ablation (MWA) as adjuvant to intralesional curettage following treatment in advanced GCTB. A retrospective review was conducted on 54 patients with...

In this paper, a new acoustic emission detection technology for boiler pipeline leakage using random forest and KNN classifier is proposed. The signal parameter index processed as feature vector, which overcomes the shortcoming of traditional method requires large number sample data training classification. First, characteristic parameters are extracted, then extracted input into vectors classification processing. Eight indexes including amplitude, ringing count, duration, energy, rise time,...

The growth, invasiveness, and metastasis of human cancers are not only determined by the cancer cells but also their microenvironment. purpose this study was to extend our previous studies examine cellular changes in tumor microenvironment (stroma) esophageal squamous cell carcinomas (ESCCs). proliferative activity, components, angiogenesis status different compartments (non-tumor stroma, periphery stroma) ESCCs were evaluated immunohistochemistry. results revealed a hyperproliferative rate...

Giant cell tumor of bone (GCTB) is a locally aggressive neoplasm with high propensity for recurrence following intralesional curettage. The introduction denosumab, RANKL inhibitor, has shown potential in facilitating joint-sparing surgery. However, concerns exist regarding its impact on local rates. This study aimed to evaluate the efficacy and safety combined preoperative denosumab adjuvant microwave ablation (MWA) treatment high-risk GCTB.

To better characterize spindle cell metaplastic carcinoma (SpCMC) of breast, a rare variant breast cancer that has been classified under the broad rubric carcinoma.We presented herein 19 cases with dominant component. All were clinically origin, showed more than 80% morphology, 10 exhibited pure spindled 8 contained invasive ductal (IDC) and 1 in situ elements.Immunohistochemical studies evidence suggesting myoepithelial epithelial differentiation as by immunoreactivity for at least one...

This meta-analysis aimed to determine whether interferon (IFN) therapy could improve clinical effects of patients with chronic hepatitis B virus (HBV)or C (HCV) infection-related primary hepatocellular carcinoma (HCC) after surgery.An electronic search from January 1998 December 2012 was conducted identify comparative studies evaluating IFN on recurrence and survival surgical treatment HCC.The estimated odds ratios (OR) for the 1-, 2-, 3- 5-year overall rates HBV-related HCC were 3.37 (95%...

Familial papillary thyroid cancer (fPTC) is recognized as a distinct entity only recently and no fPTC predisposing genes have been identified. Several potential regions susceptibility loci for sporadic PTC reported. We aimed to evaluate the role of reported risk genomic region in Chinese familial multinodular goiter (fMNG) with family.We sequenced related analyzed known family members who consented join study. These included (1) point mutations BRAF RET; (2) possible PTC; (3) suggested fMNG...

The present study reports the local recurrence, distant metastasis, progression-free survival, overall survival and radiation toxicity between two arms of stage III non-small cell lung cancer (NSCLC) treated with intensity-modulated radiotherapy (IMRT); one arm clinical target volume (CTV) other without CTV. grade 3-4 esophagitis hematological had no statistical significance. However, pneumonia rate group CTV was significantly decreased. This supports concept that NSCLC IMRT, which omitted...

Substitution of Cys674 (C674) in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) causes SERCA2 dysfunction which leads to activated inositol requiring enzyme 1 alpha (IRE1α) and spliced X-box binding protein (XBP1s) pathway accelerating cell proliferation pulmonary artery smooth muscle cells (PASMCs) followed by significant vascular remodeling resembling human hypertension. Based on this knowledge, we intend investigate other potential mechanisms involved dysfunction-induced...

X. Gong, Lu, Wu, R. Xu, Q. Tang, G. L. Wang, Zhang and Zhao Role of bone marrow imprints in haematological diagnosis: a detailed study 3781 cases Objectives: To explore the role routine (BM) diagnosis. Methods: The cellularity diagnostic accuracy BM imprints, aspirate smears trephine biopsy sections from patients were assessed using cytochemical staining. Seventy‐nine lymphoma 114 plasma cell myeloma (PCM) selected for correlation analysis tumour infiltration patterns. Another 21 to detect...

Objective To compare objective measures of needle manipulation between students and teachers acupuncture using motion video analysis technology, to help support instructional education. Methods A total 30 60 participated in this study. Acupuncture needles were inserted at LI11 videos recorded for three subtypes ‘lifting-thrusting’ manipulation: (1) ‘mild reinforcing-attenuating’; (2) ‘reinforcing’; (3) ‘attenuating’. The analysed Simi Motion 3D software acquire the movement parameters four...

e21514 Background: To evaluate the efficacy and safety for treatment of advanced soft tissue sarcoma with recombinant human adenovirus p53 (rAd-p53, Gendicine) injection radiotherapy. Methods: From October 1, 2001, to May 2013, 37 patients have been treated rAd-p53 plus Gene therapy: multipoint within neoplasm was given head neck as well abdominal pelvic tumor by ultrasound guided pulmonary metastatic lesion CT guided. injected or perfused 1 × 1012 VP / 2 ml once a week 3-16 weeks, average 7...

Primary lung cancer is one of the most frequently diagnosed cancers. The common metastatic sites are liver, bones, brain, adrenal glands and central nervous system. However, gastrointestinal metastases, particularly esophageal from rare. There no cases metastases which refer to its particular treatment.We report a case cancer. patient was 55-year-old Han Chinese man who first attended our hospital due dry cough with late-stage Three months later, complained dysphagia. Endoscopic...

Objective: To evaluate the toxicity and maximum tolerated dose (MTD) of paclitaxel concurrently with three-dimensional (3D) conformal radiotherapy for patients locally advanced non-small cell lung cancer (LANSCLC) after 2–3 cycles induction chemotherapy.Research design methods: Patients histologically proven stage III (NSCLC) were eligible. Induction chemotherapy regimen included cisplatin (40 mg/m2) on days 1 2, vinorelbine (25 8 every 3 weeks 2 or cycles, followed a month later by...

Recent researches have investigated the link between rs1800796 polymorphism (-572G/C) in interleukin-6 (IL-6) gene and risk of abdominal aortic aneurysm (AAA). However, no Chinese studies addressed association AAA this polymorphism.This case-control study included 153 patients 205 controls. Diabetes mellitus, hypertension, dyslipidemia, coronary artery disease (CAD) status were collected. The control groups 69.20 ± 7.56 68.50 7.12 years old, respectively.The analysis revealed that G allele...

Objective To investigate the expression of murine double minute 2 （mdm2） , p53, p21 and latent membrane protein 1 （LMP-1） in nasal NK/T-eell lymphoma （NKTL） analyze their relationship with clinical stage prognosis. Methods The elinicopathological follow-up data 62 patients NKTL proven by pathology were collected. Paraffin-embedded tissue sections examined for mdm2, ancl LMP-1 proteins mieroarray technique immunohistechemistry. In situ hybridization was used to detect EBER1/2. Results...

Objective: To investigate the clinicopathological and radiological features of benign fibro-osseous lesion (BFOL). Methods: Sixty-five cases craniofacial BFOL, eight peripheral ossifying fibroma (POF) one case low-grade central osteosarcoma diagnosed at Sichuan Provincial People's Hospital between January 2010 March 2019 were collected. The clinicopathologic features, hematoxylin-eosin immunohistochemical (IHC) staining radiographic analyzed. MDM2 gene amplification was detected by FISH in...

The periacetabular bone defects caused by metastatic disease often necessitate acetabular reconstruction and various techniques have been employed with varying degrees of success. purpose this study was to evaluate the efficacy safety in conjunction adjuvant microwave ablation as a surgical intervention for patients metastases.