Gang Xu

ORCID: 0000-0003-2487-7002
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About
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Research Areas
  • Sarcoma Diagnosis and Treatment
  • Lung Cancer Diagnosis and Treatment
  • Oral and Maxillofacial Pathology
  • Advanced Radiotherapy Techniques
  • Bone Tumor Diagnosis and Treatments
  • Lung Cancer Treatments and Mutations
  • Cardiovascular Function and Risk Factors
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Pulmonary Hypertension Research and Treatments
  • Gastroesophageal reflux and treatments
  • Metastasis and carcinoma case studies
  • Acupuncture Treatment Research Studies
  • Lymphoma Diagnosis and Treatment
  • Esophageal and GI Pathology
  • Cancer Research and Treatments
  • Breast Lesions and Carcinomas
  • Neuroendocrine Tumor Research Advances
  • Liver Disease Diagnosis and Treatment
  • Virus-based gene therapy research
  • Salivary Gland Tumors Diagnosis and Treatment
  • Thyroid Cancer Diagnosis and Treatment
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Medical Research and Treatments
  • Therapeutic Uses of Natural Elements
  • Breast Cancer Treatment Studies

Shenzhen Second People's Hospital
2023-2025

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2007-2024

University of Electronic Science and Technology of China
2024

Army Medical University
2023

Shanghai University of Traditional Chinese Medicine
2017-2023

Shanghai University
2023

Nanjing Medical University
2010-2021

Nanjing Drum Tower Hospital
2021

Huaian First People’s Hospital
2010-2021

First Hospital of Jilin University
2020

Detection of exogenous p53 gene and target expression in cervical cancer cell lines SiHa C33A infected by recombinant adenovirus-p53 (rAd-p53) vitro. The rAd-p53 infection evidently increased the gene, p21 Bax gene. radiosensitization rates were 1.19 1.18 To evaluate effect safety transfer combined with radiotherapy (RT) patients cancer, (group PRT) 69 was compared a control group treated alone RT) 35 cancer. Patients intratumorally injected (1 × 1012 virus particles) once week for 6 weeks....

10.1089/hum.2016.043 article EN Human Gene Therapy 2016-08-30

Preoperative denosumab has been an essential part of the management giant cell tumor bone (GCTB) which enhanced subchondral integrity and facilitated joint preservation surgery. However, evidence suggests that denosumab-induced sclerotic changes may potentially increase risk postoperative recurrence. This study evaluates efficacy microwave ablation (MWA) as adjuvant to intralesional curettage following treatment in advanced GCTB. A retrospective review was conducted on 54 patients with...

10.1186/s13018-025-05589-3 article EN cc-by-nc-nd Journal of Orthopaedic Surgery and Research 2025-02-18

In this paper, a new acoustic emission detection technology for boiler pipeline leakage using random forest and KNN classifier is proposed. The signal parameter index processed as feature vector, which overcomes the shortcoming of traditional method requires large number sample data training classification. First, characteristic parameters are extracted, then extracted input into vectors classification processing. Eight indexes including amplitude, ringing count, duration, energy, rise time,...

10.33142/mes.v6i2.15056 article EN Mechanical Engineering Science 2025-01-16

The growth, invasiveness, and metastasis of human cancers are not only determined by the cancer cells but also their microenvironment. purpose this study was to extend our previous studies examine cellular changes in tumor microenvironment (stroma) esophageal squamous cell carcinomas (ESCCs). proliferative activity, components, angiogenesis status different compartments (non-tumor stroma, periphery stroma) ESCCs were evaluated immunohistochemistry. results revealed a hyperproliferative rate...

10.1007/s13277-011-0281-3 article EN Tumor Biology 2011-12-02

Giant cell tumor of bone (GCTB) is a locally aggressive neoplasm with high propensity for recurrence following intralesional curettage. The introduction denosumab, RANKL inhibitor, has shown potential in facilitating joint-sparing surgery. However, concerns exist regarding its impact on local rates. This study aimed to evaluate the efficacy and safety combined preoperative denosumab adjuvant microwave ablation (MWA) treatment high-risk GCTB.

10.1186/s13018-024-04981-9 article EN cc-by-nc-nd Journal of Orthopaedic Surgery and Research 2024-08-17

To better characterize spindle cell metaplastic carcinoma (SpCMC) of breast, a rare variant breast cancer that has been classified under the broad rubric carcinoma.We presented herein 19 cases with dominant component. All were clinically origin, showed more than 80% morphology, 10 exhibited pure spindled 8 contained invasive ductal (IDC) and 1 in situ elements.Immunohistochemical studies evidence suggesting myoepithelial epithelial differentiation as by immunoreactivity for at least one...

10.1111/ajco.12322 article EN Asia-Pacific Journal of Clinical Oncology 2014-12-08

This meta-analysis aimed to determine whether interferon (IFN) therapy could improve clinical effects of patients with chronic hepatitis B virus (HBV)or C (HCV) infection-related primary hepatocellular carcinoma (HCC) after surgery.An electronic search from January 1998 December 2012 was conducted identify comparative studies evaluating IFN on recurrence and survival surgical treatment HCC.The estimated odds ratios (OR) for the 1-, 2-, 3- 5-year overall rates HBV-related HCC were 3.37 (95%...

10.1111/hepr.12109 article EN Hepatology Research 2013-03-14

Familial papillary thyroid cancer (fPTC) is recognized as a distinct entity only recently and no fPTC predisposing genes have been identified. Several potential regions susceptibility loci for sporadic PTC reported. We aimed to evaluate the role of reported risk genomic region in Chinese familial multinodular goiter (fMNG) with family.We sequenced related analyzed known family members who consented join study. These included (1) point mutations BRAF RET; (2) possible PTC; (3) suggested fMNG...

10.1186/1472-6823-13-48 article EN cc-by BMC Endocrine Disorders 2013-10-21

The present study reports the local recurrence, distant metastasis, progression-free survival, overall survival and radiation toxicity between two arms of stage III non-small cell lung cancer (NSCLC) treated with intensity-modulated radiotherapy (IMRT); one arm clinical target volume (CTV) other without CTV. grade 3-4 esophagitis hematological had no statistical significance. However, pneumonia rate group CTV was significantly decreased. This supports concept that NSCLC IMRT, which omitted...

10.3892/mco.2015.588 article EN Molecular and Clinical Oncology 2015-06-25

Substitution of Cys674 (C674) in the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2 (SERCA2) causes SERCA2 dysfunction which leads to activated inositol requiring enzyme 1 alpha (IRE1α) and spliced X-box binding protein (XBP1s) pathway accelerating cell proliferation pulmonary artery smooth muscle cells (PASMCs) followed by significant vascular remodeling resembling human hypertension. Based on this knowledge, we intend investigate other potential mechanisms involved dysfunction-induced...

10.1080/10641963.2023.2272062 article EN cc-by-nc Clinical and Experimental Hypertension 2023-10-29

X. Gong, Lu, Wu, R. Xu, Q. Tang, G. L. Wang, Zhang and Zhao Role of bone marrow imprints in haematological diagnosis: a detailed study 3781 cases Objectives: To explore the role routine (BM) diagnosis. Methods: The cellularity diagnostic accuracy BM imprints, aspirate smears trephine biopsy sections from patients were assessed using cytochemical staining. Seventy‐nine lymphoma 114 plasma cell myeloma (PCM) selected for correlation analysis tumour infiltration patterns. Another 21 to detect...

10.1111/j.1365-2303.2010.00825.x article EN Cytopathology 2010-12-03

Objective To compare objective measures of needle manipulation between students and teachers acupuncture using motion video analysis technology, to help support instructional education. Methods A total 30 60 participated in this study. Acupuncture needles were inserted at LI11 videos recorded for three subtypes ‘lifting-thrusting’ manipulation: (1) ‘mild reinforcing-attenuating’; (2) ‘reinforcing’; (3) ‘attenuating’. The analysed Simi Motion 3D software acquire the movement parameters four...

10.1136/acupmed-2016-011348 article EN Acupuncture in Medicine 2017-08-27

e21514 Background: To evaluate the efficacy and safety for treatment of advanced soft tissue sarcoma with recombinant human adenovirus p53 (rAd-p53, Gendicine) injection radiotherapy. Methods: From October 1, 2001, to May 2013, 37 patients have been treated rAd-p53 plus Gene therapy: multipoint within neoplasm was given head neck as well abdominal pelvic tumor by ultrasound guided pulmonary metastatic lesion CT guided. injected or perfused 1 × 1012 VP / 2 ml once a week 3-16 weeks, average 7...

10.1200/jco.2014.32.15_suppl.e21514 article EN Journal of Clinical Oncology 2014-05-20

Primary lung cancer is one of the most frequently diagnosed cancers. The common metastatic sites are liver, bones, brain, adrenal glands and central nervous system. However, gastrointestinal metastases, particularly esophageal from rare. There no cases metastases which refer to its particular treatment.We report a case cancer. patient was 55-year-old Han Chinese man who first attended our hospital due dry cough with late-stage Three months later, complained dysphagia. Endoscopic...

10.1186/s13256-021-02765-x article EN cc-by Journal of Medical Case Reports 2021-05-11

Objective: To evaluate the toxicity and maximum tolerated dose (MTD) of paclitaxel concurrently with three-dimensional (3D) conformal radiotherapy for patients locally advanced non-small cell lung cancer (LANSCLC) after 2–3 cycles induction chemotherapy.Research design methods: Patients histologically proven stage III (NSCLC) were eligible. Induction chemotherapy regimen included cisplatin (40 mg/m2) on days 1 2, vinorelbine (25 8 every 3 weeks 2 or cycles, followed a month later by...

10.1185/030079907x187874 article EN Current Medical Research and Opinion 2007-04-19

Recent researches have investigated the link between rs1800796 polymorphism (-572G/C) in interleukin-6 (IL-6) gene and risk of abdominal aortic aneurysm (AAA). However, no Chinese studies addressed association AAA this polymorphism.This case-control study included 153 patients 205 controls. Diabetes mellitus, hypertension, dyslipidemia, coronary artery disease (CAD) status were collected. The control groups 69.20 ± 7.56 68.50 7.12 years old, respectively.The analysis revealed that G allele...

10.2147/pgpm.s328894 article EN cc-by-nc Pharmacogenomics and Personalized Medicine 2021-09-01

Objective To investigate the expression of murine double minute 2 (mdm2) , p53, p21 and latent membrane protein 1 (LMP-1) in nasal NK/T-eell lymphoma (NKTL) analyze their relationship with clinical stage prognosis. Methods The elinicopathological follow-up data 62 patients NKTL proven by pathology were collected. Paraffin-embedded tissue sections examined for mdm2, ancl LMP-1 proteins mieroarray technique immunohistechemistry. In situ hybridization was used to detect EBER1/2. Results...

10.3760/cma.j.issn.0253-3766.2009.05.007 article EN 2009-05-01

Objective: To investigate the clinicopathological and radiological features of benign fibro-osseous lesion (BFOL). Methods: Sixty-five cases craniofacial BFOL, eight peripheral ossifying fibroma (POF) one case low-grade central osteosarcoma diagnosed at Sichuan Provincial People's Hospital between January 2010 March 2019 were collected. The clinicopathologic features, hematoxylin-eosin immunohistochemical (IHC) staining radiographic analyzed. MDM2 gene amplification was detected by FISH in...

10.3760/cma.j.issn.0529-5807.2020.02.004 article EN PubMed 2020-02-08

The periacetabular bone defects caused by metastatic disease often necessitate acetabular reconstruction and various techniques have been employed with varying degrees of success. purpose this study was to evaluate the efficacy safety in conjunction adjuvant microwave ablation as a surgical intervention for patients metastases.

10.3389/fonc.2024.1484876 article EN cc-by Frontiers in Oncology 2024-10-31
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