Esophageal squamous cell carcinoma (ESCC) is a prevalent and aggressive subtype of esophageal cancer, posing significant mortality economic burden, especially in East Southeast Asia. Current therapeutic strategies have limitations improving patient survival, particularly regarding disease progression resistance. This study aimed to investigate the impact neoadjuvant chemoradiotherapy (NCRT) on ESCC microenvironment. We utilized single-cell RNA sequencing systematically characterize tumor...

Background: Real-world evidence on direct oral anticoagulant outcomes among Non-Valvular Atrial Fibrillation (NVAF) patients is limited. We aimed to evaluate stroke/systemic embolism (SE) and major bleeding (MB) risks NVAF continuing or switching different anticoagulants. Methods: Using Optum’s de-identified Clinformatics® Data Mart Database, we identified initiating apixaban rivaroxaban between 1 January 2013 31 December 2021. Patients therapies within 30 days before 90 after discontinuing...

Minimally invasive McKeown esophagectomy is an important surgical approach for esophageal cancer. Anastomotic leak one of its common and serious complications. We assumed that the preoperative risk factors postoperative indicators would predict or detect anastomotic leak.Between December 2016 July 2017, patients underwent minimally were identified their variables test recorded. Fisher's exact test, 2-tailed unpaired t nonparametric logistic regression used to compare these datum between with...

Platinum-based chemotherapeutic drugs such as cisplatin, carboplatin and oxaliplatin are widely applied for the treatment of various types tumors. However, poor solubility, serious side effects, more importantly, intrinsic acquired resistance limit their clinical applications. These factors motivate scientists to design synthesize novel potent analogues lacking disadvantages platinum drugs. Platinum (IV) complexes one representatives. In this review, we summarized investigations undertaken...

Abstract The Lilium lancifolium Thunb. is a herb with multiple functions in both medicine and food China, its extracts have shown antidepressant effects. In this study, fresh bulbs of were processed to study the effects different drying processes on changes main chemical components. We found that methods can affect constituents herb. Among these components, Regaloside A has been as characteristic component. Here, Cell Counting Kit‐8 assay, Western blotting used evaluate neuroprotective A....

For thoracic surgeons, three-dimensional computed tomography bronchography and angiography (3-DCTBA) is a convenient way to analyze pulmonary variations before segmentectomy. Mediastinal lingular artery (MLA) one of the representative variations.The 3-DCTBA data left upper lobe (LUL) were collected from patients who underwent surgery January 2018 December 2019. We reviewed patterns bronchi vessels grouped them according different classifications.Among all 404 cases 3-DCTBA, mediastinal was...

慢性肾脏病（CKD）患儿生长发育较同性别、同年龄、同种族的健康儿童相对落后，但针对CKD患儿的病因及治疗仍缺乏系统研究，实现正常生长已成为CKD患儿管理中具挑战性的问题之一。本文对CKD患儿生长发育障碍的病因及其治疗进行综述，以期延缓我国CKD患儿生长发育带来的不良临床结局。.

Primary lung cancer is one of the most frequently diagnosed cancers. The common metastatic sites are liver, bones, brain, adrenal glands and central nervous system. However, gastrointestinal metastases, particularly esophageal from rare. There no cases metastases which refer to its particular treatment.We report a case cancer. patient was 55-year-old Han Chinese man who first attended our hospital due dry cough with late-stage Three months later, complained dysphagia. Endoscopic...

Anatomical sublobar resection was widely performed for small-sized nodule located in the deep field of lung. In this study, we compared surgical outcomes between anatomical left upper lobe including segmentectomy and subsegmentectomy. We also applied a technique based on bronchovascular patterns subsegmentectomy.A hundred fifty-one patients underwent our hospital period from January 2018 to December 2019 they were retrospectively reviewed. Patients' characteristics outcome subsegmentectomy...

患儿 女，13岁，因“血尿9年余，胃代食管术后贫血1年”就诊东部战区总医院儿科。患儿9年余前出现血尿，通过皮肤活检诊断X连锁Alport综合征，1年前出现进食哽咽，于外院行食管病损切除+食管良性肿瘤切除+胃代食管术，组织病理提示平滑肌瘤，术后出现血红蛋白降低。患儿贫血貌，此次入院进一步完善基因检测发现COL4A5基因外显子1杂合缺失及COL4A6基因外显子1-2杂合缺失，变异来源于母亲。结合患儿临床表现及基因结果，该患儿最终诊断为X连锁Alport综合征伴食管平滑肌瘤、胃代食管术后、缺铁性贫血。.

Osimertinib is a third-generation tyrosine kinase inhibitor that targets mutant epidermal growth factor receptor (EGFR). The success of FLAURA and ADAURA trials prompted the license for treatment EGFR non-small cell lung cancer (NSCLC) at advanced stage patients with stages IB to IIIA disease in post-operative setting. In present study, we described neoadjuvant use an NSCLC patient locally metastatic (T2aN2M0). Intriguingly, cavitated resembled impressive"Halloween pumpkin" appearance...

Balancing the allocation of preschool education resources is a crucial objective within China’s reform. Our analysis focused on investigating disparities between regions and urban-rural areas in China from 2011 to 2019, employing technique for order preference by similarity ideal solution (TOPSIS), spatial analysis, Markov chains. The results demonstrate gradual reduction gaps regions, rapid decrease gaps. Notably, Sichuan stands out with noticeably higher differences compared other...

Objective To explore the value of computer-assisted surgical systems (Higemi) for precise surgery in complex liver tumor children. Methods The clinical data 21 cases with tumors middle lobe or giant from June 2012 to January 2015 were analyzed. Computer-assisted system was used three-dimensional reconstruction and planning based upon thin-layer computed tomography (CT) imaging. It could accurately determine location adjacent relationship surrounding vessels, ascertain feasibility...

Several observational studies have compared apixaban with rivaroxaban in patients non-valvular atrial fibrillation (NVAF), but these analyses may be confounded by unmeasured characteristics. This study used provider prescribing preference (PPP) as an instrumental variable (IV) to assess the association between prescriber choice of vs. and outcomes stroke/systemic embolism (SE), major bleeding, death a retrospective cohort NVAF US. Initiators either medication were linked their prescribers...

Abstract Background: Tumor mutational burden (TMB) has been associated with efficacy of immune checkpoint therapy and is being investigated as a potential biomarker in several tumor types. The foundational studies evaluating TMB clinical trials have not examined factors that may affect estimates real-world practice, such the site biopsy relative to tissue origin. Methods: We used Flatiron Health/Foundation Medicine Clinico-Genomic Database (Presley CJ, et al. JAMA 2018; Singal G, 2019),...

Objective: To investigate risk factors for the long-term prognosis of primary focal segmental glomerulosclerosis (FSGS) and associated with renal in children. Methods: A retrospective study was conducted by collecting clinical data including general information, features pathological findings 124 children FSGS Department Pediatrics Jinling Hospital from January 2003 to December 2019. The cumulative survival rate calculated Kaplan-Meier analysis. related were identified Cox regression model...

Abstract Background: For thoracic surgeons, three-dimensional computed tomography bronchography and angiography (3-DCTBA) is a convenient way to analyze pulmonary variations before segmentectomy. Mediastinal lingular artery (MLA) one of the representative Methods: The 3-DCTBA data left upper lobe（LUL）were collected from patients who underwent surgery January 2018 December 2019. We reviewed patterns bronchi vessels grouped them according different classifications. Results: Among all 404 cases...