A5102013844- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Cytomegalovirus and herpesvirus research
- Gut microbiota and health
- Brain Metastases and Treatment
- Lung Cancer Treatments and Mutations
- Helicobacter pylori-related gastroenterology studies
- Mechanisms of cancer metastasis
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Melanoma and MAPK Pathways
- interferon and immune responses
- Metastasis and carcinoma case studies
- Liver Disease and Transplantation
- Ferroptosis and cancer prognosis
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- Breast Cancer Treatment Studies
Tianjin Medical University
2021-2025
North China University of Science and Technology
2025
First Affiliated Hospital of Zhengzhou University
2017-2024
First Affiliated Hospital Zhejiang University
2019-2024
University of Shanghai for Science and Technology
2022-2024
Qingdao Agricultural University
2023-2024
Zhengzhou University
2022-2023
Jishou University
2023
Henan Cancer Hospital
2022-2023
Zhejiang University
2021-2022
During apoptotic cell death, surface ligands initiate phagocytosis of the dying cell. Clearance these cells is thought to occur without an immune response. Since a number autoantigens are located at or within blebs, we examined whether exposure mice syngeneic by intravenous route could induce autoantibody production. Normal injected with thymocytes developed antinuclear autoantibodies and anticardiolipin anti-ssDNA antibodies. The levels were generally lower than those observed in MRL/Faslpr...
Adenovirus (Ad) gene transfer vectors are rapidly cleared from infected hepatocytes in mice. To determine which effector mechanisms responsible for elimination of the Ad vectors, we mice that were genetically compromised immune pathways [perforin, Fas, or tumor necrosis factor α (TNF-α)] with vector, Ad5-chloramphenicol acetyl transferase (CAT). Mice sacrificed at 7–60 days postinfection, and levels CAT expression liver determined by a quantitative enzymatic assay. When livers harvested 28...
The Fas/APO-1 cytotoxic pathway plays an important role in the regulation of peripheral immunity. Recent evidence indicates that this regulatory function operates through deletion activated T and B lymphocytes by CD4+ cells expressing Fas ligand. Because macrophages play a key immunity, we asked whether was involved T-cell-macrophage interactions. Two-color flow cytometry revealed receptor (FasR) expressed on resting murine peritoneal macrophages. FasR expression upregulated after activation...
We aimed to evaluate the expression of microRNA-182 (miR-182) in triple-negative breast cancer (TNBC) tissues and TNBC cell line MDA-MB-231 investigate effects mirR-182 on cellular behavior target gene profilin 1 (PFN1), thus providing new methods strategies for treatment TNBC. Quantitative real-time PCR (qRT-PCR) was utilized miR-182 tissues, relatively normal adjacent MDA-MB-231. Forty-eight hours after cells were transfected with inhibitor, qRT-PCR detect changes levels, an MTT...
Esophageal squamous cell carcinoma (ESCC) is one of the most common aggressive malignancies worldwide, particularly in northern China. The absence specific early symptoms and biomarkers leads to late-stage diagnosis, while diagnosis risk stratification are crucial for improving overall prognosis. We performed UPLC-MS/MS on 450 ESCC patients 588 controls consisting a discovery group two validation groups identify detection Bioinformatics clinical statistical methods were used profiling...
With over 70 years of development, the Department Obstetrics and Gynecology at Tianjin Medical University General Hospital has evolved into a comprehensive center for clinical care, research, education, showcasing significant influence technical strength in field obstetrics gynecology. The department operates more than 200 beds, handles 260,000 outpatient emergency visits annually, performs nearly 10,000 surgeries each year. As final referral rescue complex critical cases Tianjin, excels...
The purpose of this study was to investigate the expression and clinical significance N6-methyladenosine demethylase FTO in thyroid cancer. Bioinformatic analysis showed that downregulated cancer tissues correlated with lymph node metastasis patients. We conducted experimental verification by collecting Asian samples. results quantitative reverse transcription-PCR mRNA blood 30 patients lower than control population. At same time, we found negative 16/56 (28.57%) cases 4/40 (10.00%) nontumor...
Gastric cardia adenocarcinoma (GCA) is classified as Siewert type II at the esophagogastric junction in Western countries. The majority of GCA patients do not exhibit early warning symptoms, leading to over 90% diagnoses an advanced stage, resulting a grim prognosis, with less than 20% 5-year survival rate.
Human cytomegalovirus (HCMV) is a major risk factor in transplantation and AIDS patients, which induces high morbidity mortality. These patients infected with HCMV experience an imbalance of redox homeostasis that cause accumulation reactive oxygen species (ROS) at the cellular level. H2O2, most common species, main byproduct oxidative metabolism. However, function H2O2 on infection not yet fully understood effect mechanism N-acetylcysteine (NAC) H2O2-stimulated replication unclear. We,...
We found GCSF was involved in lipid metabolism and NAFLD development. administration increased serum triglyceride levels patients. deficiency alleviated HFD-induced insulin resistance hepatic steatosis mice. could directly act on hepatocytes through GCSFR-SOCS3-JAK-STAT3 pathway, regulate the infiltration of immune cells into liver to indirectly modulate NAFLD. Our finding indicates that may provide new strategies for treatment
AIMS: The prognosis of hepatocellular carcinoma (HCC) remains dismal, and its molecular pathogenesis has not been completely defined. enzyme 3-mercaptopyruvate sulfurtransferase (MPST) regulates endogenous hydrogen sulfide (H2 S) biosynthesis. However, the role MPST in HCC never intensively investigated.MPST protein expression was analysed tumour tissues matched adjacent tissues. effect on progression studied vitro vivo.The mRNA significantly downregulated samples compared with their paired...
Background The impact of hospital volume on the long-term survival esophageal squamous cell carcinoma (ESCC) has not been well assessed in China, especially for stage I–III ESCC. We performed a large sample size study to assess relationships between and effectiveness ESCC treatment value at lowest risk all-cause mortality after esophagectomy China. Aim To investigate prognostic assessing postoperative patients Methods date 158,618 with were collected from database (1973–2020) established by...
Background: High rate of tumor recurrence jeopardized the long-term survival hepatocellular carcinoma (HCC) patients with complete response to transarterial chemoembolization (TACE). This study aims evaluate benefit liver resection (LR) following TACE for intermediate-stage HCC. Methods: A total 281 HCC followed by persistent observation (TACE group) or LR (TLR from January 01, 2011 December 31, 2021 three institutions in China were included. Overall (OS) and disease-free (DFS) compared...
Ulcerative colitis (UC) is one of the most important risk factors for developing colitis-associated cancer (CAC). Persistent DNA damage increases CAC and has been observed in patients with UC. We aimed to identify regulatory role RAD50, a double-strand breaks (DSBs) sensor, UC progression CAC.
To analyze the association between non-alcoholic fatty liver disease (NAFLD) and incidence of diabetic nephropathy in patients with type 2 diabetes, was assessed 413 patients, by testing 24 h urinary albumin excretion rate (UAER). The NAFLD diagnosed based on patient's medical history ultrasound. difference without tested X². Multivariate logistic regression analysis used to assess factors associated among patients. Total 363 out were enrolled this study. incidences participants...