A5101477308- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Sulfur-Based Synthesis Techniques
- Cyclopropane Reaction Mechanisms
- Medicinal Plants and Bioactive Compounds
- Chemical Synthesis and Analysis
- Porphyrin and Phthalocyanine Chemistry
- Genetics, Aging, and Longevity in Model Organisms
- Flavonoids in Medical Research
- Soil erosion and sediment transport
- Parasite Biology and Host Interactions
- Hydrology and Watershed Management Studies
- Aeolian processes and effects
- Phytochemicals and Antioxidant Activities
- Bioactive Compounds and Antitumor Agents
- Ginseng Biological Effects and Applications
- Synthesis of Indole Derivatives
- Asymmetric Synthesis and Catalysis
- Sodium Intake and Health
- Parasitic Diseases Research and Treatment
- Acupuncture Treatment Research Studies
- Parasites and Host Interactions
- Photodynamic Therapy Research Studies
- Mitochondrial Function and Pathology
- Synthesis and Characterization of Pyrroles
Jilin Agricultural University
2024
Nanjing Forestry University
2020-2023
Hunan Normal University
2018
Peking University People's Hospital
2018
Peking University
2018
Children's Hospital of Zhejiang University
2017
Wuhan University
2003-2014
Polyglutamine (polyQ) aggregation plays a pivotal role in the pathological process of Huntington’s disease and other polyQ disorders. Therefore, strategies aiming at restoring dysfunction reducing stresses mediated by toxicity are therapeutic interest for proteotoxicity diseases. Salidroside, glycoside from Rhodiola rosea, has been shown to have variety bioactivities, including antioxidant activity. Using transgenic Caenorhabditis elegans models, we show here that salidroside is able reduce...
A simple method for the preparation of imidazo[4,5-b]indole-2-thiones from 2-alkynylnitrobenzenes and thioureas is described. In reaction, a Wittig-like process was triggered by PPh3 followed cyclization step. The products were afforded in yields 70–98% under mild conditions. Additionally, stable could be prepared via coupling
Gully erosion poses greater threat to ecological and food security globally. The gully development rate the contributions of primary influencing factors have not been thoroughly understood, primarily due complicated environmental conditions characterized by climate, soil, topography, human activities. Therefore, this study was conducted explore its driving from 2013 2021 based on historical Google Earth images field investigation in a typical rolling hilly watershed northeast China. climatic...
An efficient palladium-catalyzed one-pot synthesis of imidazoloindolines from 2-alkynyl arylazides under mild reaction conditions has been described.
A novel and efficient synthetic method for the preparation of various pyrroloindolines from 2-alkynyl arylazides thioacetamides was developed. The reaction carried out in a one-pot process under mild conditions to afford products moderate good yields, which has potential be used organic synthesis.
Abstract A synthetic strategy for the construction of 2,2‐disubstituted indolin‐3‐ones from 2‐alkynylnitroarenes and ketones has been described. The corresponding indolin‐3‐one derivatives were afforded in moderate to excellent product yields by using mild conditions. After a Wittig‐like process, key intermediates 3 H ‐indol‐3‐ones generated 2‐alkynylnitroarenes, which could be further transformed desired products through Mannich addition. magnified image
Salidroside, a major active ingredient isolated from Rhodiola rosea , has long application in Chinese medical history. It widely demonstrated effects on fatigue, psychological stress, and depression exhibits potential antihypoxia activity. Emerging evidence shows that hypoxia is an important independent risk factor for erectile dysfunction (ED). The aim of this study was to clarify the effect salidroside hypoxia‐induced phenotypic transformation corpus cavernosum smooth muscle cells...
An efficient NBS-assisted palladium-catalyzed bromination/cross-coupling synthesis of 3-thiocyanindoles from 2-alkynyl arylazides with KSCN has been described.
A novel one-pot method to prepare 3-hydroxy-2-oxindoles <italic>via</italic> acyloin rearrangements of 2-hydroxy-indolin-3-ones generated <italic>in situ</italic> from 2-alkynyl arylazides has been described.
A simple and novel metal-free reduction of azides to amines in the presence DBU is reported. This DBU-promoted transformation features good functional group tolerance high chemo-selectivity.
Abstract We describe a novel one‐pot three‐step reaction of 2‐alkynyl arylazides through palladium‐catalyzed formation 3‐hydroxy‐3‐phenylindolin‐2‐ones followed by hydrolysis amide bonds and copper‐catalyzed decarboxylation to give 2‐aminobenzophenones. This synthetic method works well with various affords the products in moderate good yields under mild conditions.
Objectives: To access the state of salt intake in patients with hypertension Beijing and analyze relationship between blood pressure level hypertensive target organ damage. Methods: This was a cross-section survey. Study subjects were essential large hospitals or community Beijing. Patients divided into three groups, that low group (urine sodium < 100mmol/d, equal to 6 g/d), medium 100–199mmol/d, 6–12 g/d) high > 200mmol/d, 12 g/d). We compared difference clinic ambulatory level, thickness...