A5037551619- Zebrafish Biomedical Research Applications
- Circadian rhythm and melatonin
- Cancer Immunotherapy and Biomarkers
- RNA Interference and Gene Delivery
- Birth, Development, and Health
- Effects and risks of endocrine disrupting chemicals
- Nanoparticles: synthesis and applications
- Adipose Tissue and Metabolism
- Melamine detection and toxicity
- Gastric Cancer Management and Outcomes
- Molecular Junctions and Nanostructures
- Colorectal Cancer Treatments and Studies
- Toxic Organic Pollutants Impact
- Electrochemical Analysis and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Environmental Toxicology and Ecotoxicology
- Advanced biosensing and bioanalysis techniques
- Analytical Chemistry and Sensors
- Reproductive biology and impacts on aquatic species
- Sirtuins and Resveratrol in Medicine
- Porphyrin and Phthalocyanine Chemistry
- Photodynamic Therapy Research Studies
- Cannabis and Cannabinoid Research
- PARP inhibition in cancer therapy
- Pancreatic and Hepatic Oncology Research
Tianjin Medical University General Hospital
2016-2023
Tianjin Medical University
2022
Mayo Clinic
2019
Chinese PLA General Hospital
2015
Nankai University
2011-2013
In-Q-Tel
2012
Environmental endocrine chemicals have various adverse effects on the development of vertebrates. Fluorene-9-bisphenol (BHPF), a substitute bisphenol A (BPA), is widely used in commercial production. The BHPF and behavior are unclear. Melatonin plays protective role under many unfavorable conditions. In this study, we investigated behaviors zebrafish whether melatonin reverses induced by BHPF. Zebrafish embryos were exposed to 0.1, 10, or 1000 nmol/L with without 1 μmol/L from 2 hours...
Here, we report that both nano-silica (SiO<sub>2</sub>-NPs) and reserpine can elicit depression-like behavior in adult zebrafish a novel tank test.
Resveratrol exerts protective effects on ovarian injury, decreased oocyte quality and zona pellucida softening due to obesity.
We wished to evaluate the impact of S-1 combined with oxaliplatin (SOX regimen) as neoadjuvant chemotherapy on surgical outcomes after gastrectomy D2 lymphadenectomy.
Journal Article A progressive approach on zebrafish toward sensitive evaluation of nanoparticles' toxicity Get access Yang Liu, Liu State Key Laboratory Medicinal Chemical Biology, Bioactive Materials, Ministry Education, College Life Science, Nankai University, Tianjin, 300071, China. Fax: +86-22-23507022; Tel: +86-22-23507022 Search for other works by this author on: Oxford Academic Google Scholar Bin Functional Polymer The Institute Chemistry, +86-22-23503510; +86-22-23502023 Daofu Feng,...
Multi biomarkers' assays are of great significance in clinical diagnosis. A label-free multi tumor markers' parallel detection system was proposed based on a light addressable potentiometric sensor (LAPS). Arrayed LAPS chips with basic structure Si(3)N(4)-SiO(2)-Si were prepared silicon wafers, and the for this component developed user friendly controlling interfaces. Then l-3,4-dihydroxyphenyl-alanine (L-Dopa) hydrochloric solution used to initiate surface LAPS. The L-Dopa immobilization...
Nanoparticles are widely used in nanomedicine, raising concerns about their toxicity. In this study, the toxicity of bismuth–asparagine coordination polymer spheres (BACP-2) was assessed zebrafish embryos. Injection 1–4 cell stage embryos with BACP-2 resulted smaller head size (particularly eye size), shorter body length, and pericardial edemas. The severity occurrence resulting phenotype were concentration-dependent. expression genes such as krox20, orthodenticle homeobox 2 (otx2), cardiac...
As a highly effective plant hormone, the overuse of 6-benzylaminopurine (6-BA) may pose potential threats to organisms and environment. Melatonin is widely known for its regulation sleep rhythm, it also shows beneficial effect in variety adverse situations. In order investigate harm 6-BA vertebrates whether melatonin can reverse toxicity induced by 6-BA, we analyzed circadian rhythm cardiovascular system zebrafish, further clarified role thyroid endocrine system. The exposure well-developed...
Abstract The application of probes for optical imaging is becoming popular as they have high safety and good biocompatibility. We prepared two kinds glycosyl‐modified diporphyrins, their potentials fluorescent were tested the first time. After preparation porphyrin monomers, Ag‐promoted coupling monomers was used to obtain glucose‐modified dimer (GPD) lactose‐modified (LPD). strong interaction between rings achieves red‐shifted emission, thus circumvents autofluorescence light‐scattering in...
In this study, we employed zebrafish as an animal model to evaluate the biological effect of polyhydroxyalkanoates (PHAs) on early development<italic>via</italic>morphological, physiological, and behavioural analyses.
Melamine cyanuric acid (MCA) is a flame retardant linked by hydrogen bonds between melamine and acid. MCA used in an excellent series of phosphorus nitrogen retardants. can harm the kidney, liver, testis, spleen cells. However, effects on emotions behaviour adolescent mice have not yet been investigated. In this article, male were exposed to at 10, 20, 40 mg/kg for four weeks. exposure resulted enhanced mouse locomotor nocturnal activity. We also observed anxiety-like depression-like...
A bio-mimetic anchoring strategy based on L-3,4-dihydroxyphenylalanine (L-DOPA) was exploited to activate the surface of light addressable potentiometric sensor (LAPS), with structure Si3N4/SiO2/Si. X-Ray photoelectron spectroscopy (XPS) measurements were carried out ascertain its existence. The protein's immobilization L-DOPA-initiated LAPS also tested by our system. Then L-DOPA-activated applied in unlabeled rabbit anti-mouse immunoglobulin (IgG) detection. maximum sensitivity antigen (Ag)...
In this study, a triblock copolymer PDMAEMA-b-poly(PEGMA)-b-PDMAEMA (DED) and diblock PDMAEMA-b-poly(PEGMA) (DE) were synthesized by atom transfer radical polymerization (ATRP) with the initiators bis(2-bromoisobutyryl) hexanediamide (BiBH) ethyl 2-bromoisobutyrate (EBiB), respectively. Their molecular weights chemical compositions almost same only difference being in block sequences. The influence of structures on gene transfection results was investigated systematically. Gel retardation...
The unique behaviors of engineered nanomaterials (eNMs) bring many exciting applications, and also raise safety concerns. Zebrafish have been widely used as a model organism for toxicity tests eNMs. Commonly, the equivalent toxic dose drug is estimated by level malformation in zebrafish at 5 or 6 days post-fertilization (dpf). However, this method only suitable evaluation general toxicity. To distinguish specific aspects drug, much more sensitive approach needed. Here, we first evaluated NPs...
Colorectal cancer (CRC) with BRAF (V600E) is associated microsatellite instability (MSI) that predicts response to immune checkpoint inhibitors.We demonstrated the interrogation of TCGA RNA-seq human datasets revealed BRAFV600E tumors had significantly higher Programmed Death Ligand 1 (PD-L1) mRNA compared non-mutated CRCs.Also, MSI-H were evaluated as PD-L1 than MSS CRCs.Inhibition MEK/ERK by cobimetinib or CDK inhibitor dinaciclib was shown attenuate mutant BRAF-induced coincident reduced...
Optical tracking and biocompatibility study of nanoparticles (NPs) have received lots attention in nano-research areas. In this paper, PDMAEMA-b-poly(PEGMA)-b-PDMAEMA–fluorescein (DED–F) NPs were synthesized by encapsulating hydrophobic fluorescein an amphiphilic triblock copolymer DED. DED possessed gene transfection functions as our previous work demonstrated the encapsulated guaranteed bioimaging capability DED–F NPs. The assessments conducted vitro using PC12 cells vivo through model...
MCA is a halogen-free flame retardant. It can cause damage to other tissues such as the kidneys and liver. However, effects on circadian rhythm thyroid in adult mice have not been studied. In this article, male received at concentrations of 0, 10, 20, 30 mg/kg. The results showed that time spending wheel-running rest bouts changed different period after exposure. disrupted T3 T4 hormone homeostasis decreased expression synthesis genes. histological morphology gland was damaged. suggested...