A5103239052- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Luminescence and Fluorescent Materials
- Nanoparticle-Based Drug Delivery
- Cancer therapeutics and mechanisms
- Computational Drug Discovery Methods
- Ocular Infections and Treatments
- Supramolecular Self-Assembly in Materials
- HIV, TB, and STIs Epidemiology
- Prostate Cancer Treatment and Research
- Biosensors and Analytical Detection
- Cholinesterase and Neurodegenerative Diseases
- Medical and Biological Ozone Research
- Graphene and Nanomaterials Applications
- Biofield Effects and Biophysics
- Gaze Tracking and Assistive Technology
- Acute Kidney Injury Research
- Photoreceptor and optogenetics research
- Adenosine and Purinergic Signaling
- Immune cells in cancer
- HIV, Drug Use, Sexual Risk
- Coronary Interventions and Diagnostics
- Cancer-related gene regulation
- Adolescent Sexual and Reproductive Health
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Tianjin University of Traditional Chinese Medicine
2019-2024
Peking Union Medical College Hospital
2010-2023
Tianjin University of Science and Technology
2023
Northwest A&F University
2013-2022
Development Research Center
2022
Fudan University
2022
Zhongshan Hospital
2022
Northeast Forestry University
2021
Beijing Center for Disease Prevention and Control
2019
Fluorescence imaging in vivo will pave an important way for the evaluation of biomaterials. The major advantage fluorescence compared to other modalities is possibility tracking two or more probes simultaneously with multispectral imaging. It essential elucidate location, erosion, drug release and resection implanted biomaterials vivo. Herein, a thermosensitive hydrogel protoporphyrin core based on PEG PCL copolymer (PCL–PEG–PPOR–PEG–PCL) was synthesized by ring-opening polymerization using...
Motor imagery (MI) is a classical method of brain–computer interaction (BCI), in which electroencephalogram (EEG) signal features evoked by imaginary body movements are recognized, and relevant information extracted. Recently, various deep-learning methods being focused on finding an easy-to-use EEG representation that can preserve both temporal spatial information. To further utilize the signals, improved 3D densely connected multi-branch convolutional neural network (dense M3D CNN) for MI...
We previously reported lysine-porphyrin conjugate 4i, which had potent photosensitive antibacterial effect on clinical isolated Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) bacterial strains. The aim of this paper is to evaluate the mechanism photodynamic chemotherapy 4i (4i-PACT) in vitro treatment vivo. Atomic force microscopy (AFM) revealed 4i-PACT could effectively destroy membrane wall, making content leakage,...
Cationic porphyrin conjugate, protoporphyrin IX-methyl ethylenediamine derivative (PPIX-MED) has a potent photosensitive antibacterial effect on clinically isolated bacteria, including methicillin-resistant Staphylococcus aureus , (MRSA), Escherichia coli and Pseudomonas aeruginosa . This study investigated (i) the PPIX-MED-mediated antimicrobial photodynamic these three species in vitro (ii) of therapy (aPDT) combined with use an antibiotic healing vivo third-degree burns rats wounds...
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by inflammation and ulceration of the digestive tract. Photodynamic therapy (PDT) with a novel photosensitizer LD4 was used to treat UC rat models explore therapeutic effect mechanism LD4-PDT on UC. 16S ribosomal RNA detect composition Gut microbiota. Our findings indicate that could protect integrity colonic mucosa, alleviate response promote healing mucosa. Mechanism studies demonstrated inhibit NF-κB signaling pathway,...
Proteolysis targeting chimera (PROTAC), a novel drug discovery strategy, utilizes the ubiquitin-proteasome system to degrade target proteins in cells. While Western blotting, mass spectrometry, and Lumit Immunoassay have been instrumental determining protein levels, rapid screening of PROTACs continues pose challenges, necessitating development alternative methodologies. We herein reported an high-throughput method for using dual-reporter expressing Renilla luciferase (RLUC)-fused enhanced...
Resveratrol and curcumin, as natural flavones products, have good therapeutic effect in acute chronic inflammation; on the other hand, tetramethylpyrazine (TMP) has angiogenesis vessel protection well anti-inflammatory function. In this paper, of tetramethylpyrazine, resveratrol curcumin (TRC) combination inflammation was reported vivo.The dose combined three products optimized based paw swelling mouse model with a Uniform Design methodology. The TRC investigated by using collagen-induced...
Photodynamic antimicrobial chemotherapy (PACT), as a novel and effective therapeutic modality to eradicate drug resistant bacteria without provoking multidrug resistance, has attracted increasing attention. This study examined the efficacy of cationic amino acid-porphyrin conjugate 4I with four lysine groups against two different clinical isolated strains (drug sensitive resistant) Acinetobacter baumannii species its toxicity on murine dermal fibroblasts in vitro, well effect PACT acute,...
Visualization of a drug delivery system could reveal the pharmacokinetic properties, which is essential for design novel system. In vivo optical imaging offers an advanced tool to monitor release process and therapeutic effect by combination fluorescence bioluminescence imaging. Multispectral can separate carrier without interference. Herein, dual fluorescent anti-tumor was monitored with doxorubicin-loaded hydrogel further explore application porphyrin-incorporated four-arm PEG-PCL...
Real-time tracking of a drug delivery system and its therapeutic effects in vivo are crucial to designing novel pharmaceutical revealing the mechanism therapy. Multispectral fluorescence imaging can locate carrier simultaneously without interference. This advanced method enables system. Herein, doxorubicin (Dox) loaded zinc phthalocyanine incorporated hydrogel was developed as dual fluorescent monitor release degradation carrier. An injectable thermosensitive based on four-arm poly(ethylene...