A5061326842- Peripheral Artery Disease Management
- Lymphatic System and Diseases
- Diagnosis and Treatment of Venous Diseases
- Liver Disease and Transplantation
- Renal Transplantation Outcomes and Treatments
- Cardiovascular Health and Risk Factors
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Causal Inference Techniques
- Statistical Methods in Clinical Trials
- Statistical Methods and Inference
- Diabetic Foot Ulcer Assessment and Management
- Cerebrovascular and Carotid Artery Diseases
- Machine Learning in Healthcare
- Cardiac Health and Mental Health
- Medical and Biological Ozone Research
- Transplantation: Methods and Outcomes
- Lung Cancer Treatments and Mutations
- Health disparities and outcomes
- Organ Donation and Transplantation
- Listeria monocytogenes in Food Safety
- Cardiovascular Health and Disease Prevention
- Ovarian function and disorders
- Nutritional Studies and Diet
Northwestern University
2016-2025
Lanzhou University
2011-2024
Chinese Research Academy of Environmental Sciences
2023-2024
First Hospital of Lanzhou University
2011-2024
Wuhan Pulmonary Hospital
2023
Northwestern Medicine
2022-2023
Northwestern University
2023
Harbin Medical University
2018-2022
Tianjin Medical University Cancer Institute and Hospital
2022
Mayo Clinic in Florida
2021
In a longitudinal clinical study to compare two groups, the primary end point is often time specific event (eg, disease progression, death). The hazard ratio estimate routinely used empirically quantify between-group difference under assumption that of functions approximately constant over time. When this plausible, such may capture relative between survival curves. However, meaning difficult, if not impossible, interpret when underlying proportional hazards violated (ie, time). Although...
<h3>Importance</h3> Cholesterol is a common nutrient in the human diet and eggs are major source of dietary cholesterol. Whether cholesterol or egg consumption associated with cardiovascular disease (CVD) mortality remains controversial. <h3>Objective</h3> To determine associations incident CVD all-cause mortality. <h3>Design, Setting, Participants</h3> Individual participant data were pooled from 6 prospective US cohorts using collected between March 25, 1985, August 31, 2016. Self-reported...
Clinical practice guidelines state there is insufficient evidence to support advising patients with peripheral artery disease (PAD) participate in a home-based walking exercise program.To determine whether program that uses group-mediated cognitive behavioral intervention, incorporating both group and self-regulatory skills, can improve functional performance compared health education control PAD without intermittent claudication.Randomized controlled clinical trial of 194 PAD, including...
Polycystic ovary syndrome (PCOS) is the most frequent endocrinopathy in women of reproductive age. It difficult to treat PCOS because its complex etiology and pathogenesis. Here, we characterized roles gut microbiota on pathogenesis treatments letrozole (a nonsteroidal aromatase inhibitor) induced rat model. Changes estrous cycles, hormonal levels, ovarian morphology by PCR-DGGE real-time PCR were determined. The results showed that rats displayed abnormal cycles with increasing androgen...
Summary For a study with an event time as the endpoint, its survival function contains all information regarding temporal, stochastic profile of this outcome variable. The probability at specific point, say t, however, does not transparently capture temporal endpoint up to t. An alternative is use restricted mean (RMST) t summarize profile. RMST subjects in population followed and simply area under curve advantages using such quantification over rate have been discussed setting fixed-time...
<h3>Importance</h3> Clinical practice guidelines support home-based exercise for patients with peripheral artery disease (PAD), but no randomized trials have tested whether an intervention without periodic medical center visits improves walking performance. <h3>Objective</h3> To determine a consisting of wearable activity monitor and telephone coaching ability over 9 months in PAD. <h3>Design, Setting, Participants</h3> Randomized clinical trial conducted at 3 US centers. Patients PAD were...
<h3>Importance</h3> Supervised high-intensity walking exercise that induces ischemic leg symptoms is the first-line therapy for people with lower-extremity peripheral artery disease (PAD), but adherence poor. <h3>Objective</h3> To determine whether low-intensity home-based at a comfortable pace significantly improves ability in PAD vs and nonexercise control. <h3>Design, Setting, Participants</h3> Multicenter randomized clinical trial conducted 4 US centers including 305 participants....
Receptor tyrosine-protein kinase ERBB3 (HER3) is expressed in most EGFR-mutated lung cancers but not a known mechanism of resistance to EGFR inhibitors. HER3-DXd an antibody-drug conjugate consisting HER3 antibody attached topoisomerase I inhibitor payload via tetrapeptide-based cleavable linker. This phase I, dose escalation/expansion study included patients with locally advanced or metastatic non-small cell cancer (NSCLC) prior tyrosine (TKI) therapy. Among 57 receiving 5.6 mg/kg...
For designing, monitoring, and analyzing a longitudinal study with an event time as the outcome variable, restricted mean (RMET) is easily interpretable, clinically meaningful summary of survival function in presence censoring. The RMET average all potential times measured up to point τ can be estimated consistently by area under Kaplan–Meier curve over |$[0, \tau ]$|. In this paper, we class regression models, which directly relates its "baseline" covariates for predicting future subjects'...
When comparing a new treatment with control in randomized clinical study, the effect is generally assessed by evaluating summary measure over specific study population. The success of trial heavily depends on choice such In this paper, we show systematic, effective way to identify promising population, for which expected have desired benefit, utilizing data from current involving similar comparator treatments. Specifically, using existing data, first create parametric scoring system as...
High-dimensional DNA methylation markers may mediate pathways linking environmental exposures with health outcomes. However, there is a lack of analytical methods to identify significant mediators for high-dimensional mediation analysis.Based on sure independent screening and minimax concave penalty techniques, we use joint significance test effect. We demonstrate its practical performance using Monte Carlo simulation studies apply this method investigate the extent which causal pathway from...
Noninvasive biomarkers are needed to monitor stable patients after kidney transplant (KT), because subclinical acute rejection (subAR), currently detectable only with surveillance biopsies, can lead chronic and graft loss. We conducted a multicenter study develop blood-based molecular biomarker for subAR using peripheral blood paired biopsies strict clinical phenotyping algorithms discovery validation. At predefined threshold, 72% 75% of KT recipients achieved negative test correlating the...
The association between high-density lipoprotein cholesterol (HDL-C) and coronary heart disease (CHD) events is not well described in individuals with very high levels of HDL-C (>80 mg/dL).Using pooled data from 6 community-based cohorts we examined CHD total mortality risks across a broad range HDL-C, including values excess 80 mg/dL. We used Cox proportional hazards models penalized splines to assess multivariable, adjusted, sex-stratified associations the hazard for mortality, using 45...
Background and objectives Subclinical acute rejection is associated with poor outcomes in kidney transplant recipients. As an alternative to surveillance biopsies, noninvasive screening has been established a blood gene expression profile. Donor-derived cellfree DNA (cfDNA) used detect patients allograft dysfunction but not tested extensively stable patients. We hypothesized that we could complement diagnostic performance for subclinical by combining donor-derived cfDNA profile assay....
ABSTRACT Percentage is widely used to describe different results in food microbiology, e.g., probability of microbial growth, percent inactivated, and positive samples. Four sets percentage data, percent-growth-positive, germination extent, for one cell grow, maximum fraction tubes, were obtained from our own experiments the literature. These data modeled using linear logistic regression. Five methods compare goodness fit two models: predictions closer observations, range differences...
Background We studied whether a 6‐month group‐mediated cognitive behavioral ( GMCB ) intervention for peripheral artery disease PAD participants, which promoted home‐based walking exercise, improved 6‐minute walk and other outcomes at 12‐month follow‐up, 6 months after completing the intervention, compared to control group. Methods Results randomized participants or During phase I (months 1 6), used group support self‐regulatory skills during weekly on‐site meetings help adhere exercise. The...
Background Consider a comparative, randomized clinical study with specific event time as the primary end point. In presence of censoring, standard methods summarizing treatment difference are based on Kaplan–Meier curves, logrank test, and point interval estimates via Cox’s procedure. Moreover, for designing monitoring study, one usually utilizes an event-driven scheme to determine sample sizes interim analysis points. Purpose When proportional hazards (PHs) assumption is violated, test may...
<h3>Importance</h3> Benefits of granulocyte-macrophage colony-stimulating factor (GM-CSF) for improving walking ability in people with lower extremity peripheral artery disease (PAD) are unclear. Walking exercise may augment the effects GM-CSF PAD, since exercise-induced ischemia enhances progenitor cell release and promote homing to ischemic calf muscle. <h3>Objectives</h3> To determine whether combined supervised treadmill improves 6-minute walk distance, compared alone alone; more than...
<h3>Importance</h3> Wide heterogeneity exists in acute myocardial infarction treatment and outcomes India. <h3>Objective</h3> To evaluate the effect of a locally adapted quality improvement tool kit on clinical process measures Kerala, southern Indian state. <h3>Design, Setting, Participants</h3> Cluster randomized, stepped-wedge trial conducted between November 10, 2014, 9, 2016, 63 hospitals India, with last date follow-up December 31, 2016. During 5 predefined steps over study period,...