A5085243217- Peripheral Artery Disease Management
- Diagnosis and Treatment of Venous Diseases
- Lymphatic System and Diseases
- Diabetic Foot Ulcer Assessment and Management
- Cerebrovascular and Carotid Artery Diseases
- Muscle metabolism and nutrition
- Medical and Biological Ozone Research
- Stroke Rehabilitation and Recovery
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Musculoskeletal pain and rehabilitation
- Complementary and Alternative Medicine Studies
- Botulinum Toxin and Related Neurological Disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Systemic Sclerosis and Related Diseases
- Autophagy in Disease and Therapy
- Acupuncture Treatment Research Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Muscle and Compartmental Disorders
- Curcumin's Biomedical Applications
- Obesity, Physical Activity, Diet
- Antioxidant Activity and Oxidative Stress
- Hereditary Neurological Disorders
- Cardiovascular Health and Disease Prevention
- Coronary Interventions and Diagnostics
Northwestern University
2018-2025
Weatherford College
2024
Inner Mongolia Medical University
2022
<h3>Importance</h3> Clinical practice guidelines support home-based exercise for patients with peripheral artery disease (PAD), but no randomized trials have tested whether an intervention without periodic medical center visits improves walking performance. <h3>Objective</h3> To determine a consisting of wearable activity monitor and telephone coaching ability over 9 months in PAD. <h3>Design, Setting, Participants</h3> Randomized clinical trial conducted at 3 US centers. Patients PAD were...
<h3>Importance</h3> Supervised high-intensity walking exercise that induces ischemic leg symptoms is the first-line therapy for people with lower-extremity peripheral artery disease (PAD), but adherence poor. <h3>Objective</h3> To determine whether low-intensity home-based at a comfortable pace significantly improves ability in PAD vs and nonexercise control. <h3>Design, Setting, Participants</h3> Multicenter randomized clinical trial conducted 4 US centers including 305 participants....
<h3>Importance</h3> Chronic low back pain (CLBP), the most prevalent chronic condition, imparts substantial disability and discomfort. Cognitive behavioral therapy (CBT) reduces effect of CLBP, but access is limited. <h3>Objective</h3> To determine whether a single class in evidence-based management skills (empowered relief) noninferior to 8-session CBT superior health education at 3 months after treatment for improving catastrophizing, intensity, interference, other secondary outcomes....
Few effective therapies exist to improve lower extremity muscle pathology and mobility loss due peripheral artery disease (PAD), in part because mechanisms associated with functional impairment remain unclear. To better understand of PAD, we performed in-depth transcriptomic proteomic analyses on gastrocnemius biopsies from 31 PAD participants (mean age, 69.9 years) 29 age- sex-matched non-PAD controls 70.0 free diabetes or limb-threatening ischemia. Transcriptomic suggested activation...
The current study supports the hypothesis that in people with PAD, cocoa flavanols activate Nrf2, thereby increasing antioxidant protein levels, protecting against skeletal muscle damage, and mitochondrial abundance. These results suggest Nrf2 activation may be an important therapeutic target for improving walking performance PAD.
Cocoa and its major flavanol component, epicatechin, have therapeutic properties that may improve limb perfusion increase calf muscle mitochondrial activity in people with lower extremity peripheral artery disease (PAD).In a phase II randomized clinical trial, to assess whether 6 months of cocoa improved walking performance PAD, compared placebo.Six-month double-blind, trial which participants PAD were either beverage versus placebo beverage. The contained 15 g 75 mg epicatechin daily....
People with lower extremity peripheral artery disease (PAD) have increased oxidative stress, impaired mitochondrial activity, and poor walking performance. NAD+ reduces stress is an essential cofactor for respiration. Oral nicotinamide riboside (NR) increases bioavailability of in humans. Among 90 people PAD, this randomized double-blind clinical trial assessed whether 6-months NR, without resveratrol, improves 6-min walk distance, compared to placebo, at 6-month follow-up. At follow-up, NR...
Background Mitochondrial abnormalities exist in gastrocnemius muscle of people with peripheral artery disease (PAD). Whether mitochondrial biogenesis and autophagy are associated greater ischemia or walking impairment PAD is unknown. Methods Results Protein markers the abundance electron transport chain complexes were quantified biopsies from without PAD. Their 6‐minute walk distance 4‐m gait speed measured. Sixty‐seven participants (mean age 65.0 years [±6.8], 16 [23.9%] women, 48 [71.6%]...
Importance Patients with lower extremity peripheral artery disease (PAD) have reduced perfusion, impaired skeletal muscle function, and poor walking performance. Telmisartan (an angiotensin receptor blocker) has properties that reverse these abnormalities. Objective To determine whether telmisartan improves 6-minute walk distance, compared placebo, in patients PAD at 6-month follow-up. Design, Setting, Participants Double-blind, randomized clinical trial conducted 2 US sites involving 114...
The prognostic significance of the six-minute walk distance for lower extremity events in people with peripheral artery disease (PAD) is unknown. This longitudinal study assessed whether a poorer at baseline was associated higher rates subsequent atherosclerotic PAD. A total 369 patients (mean age 69.4 ± 10.0 years; mean ankle–brachial index (ABI) 0.67 0.17; 31% women; 30% black individuals) from Chicago-area medical centers PAD were enrolled. Participants underwent testing and returned...
Background Supervised exercise therapy (SET) is the first‐line for walking impairment in peripheral artery disease (PAD). This study evaluated association between attendance at SET and improved performance, compared with a control group, PAD. Methods Results Data from 2 randomized clinical trials of PAD were combined. In each trial, participants to 3 times weekly supervised treadmill or an attention group 6 months (maximum, 77 sessions). Participants categorized into tertiles, according...
Background Among people with lower extremity peripheral artery disease, obesity is associated faster functional decline than normal weight. The association of weight loss in disease unknown. Methods and Results Adults an ankle-brachial index <0.90 were identified from Chicago-area hospitals 2002-2004. Weight 6-minute walk distance measured annually. change categories or gain (≥5 pounds/year at ≥1 visit) stable (weight <5 pounds each visit). Participants reported whether was "intentional"...
Background Associations of 1-year change in functional performance measures with subsequent mobility loss and mortality people lower extremity peripheral artery disease are unknown. Methods Results Six-minute walk 4-meter walking velocity (usual fastest pace) were measured at baseline 1 year later 612 (mean age 71±9 years, 37% women). Participants categorized into tertiles, based on changes measures. Cox proportional hazards models used to examine associations between each measure mortality,...
Background: This study evaluated the association of smoking with mitochondrial function in gastrocnemius muscle people peripheral artery disease (PAD). Methods: Participants were enrolled from Chicago, Illinois and consented to biopsy. Mitochondrial oxidative capacity was measured respirometry. Abundance voltage-dependent anion channel (VDAC) (mitochondrial membrane abundance), peroxisome proliferator-activated receptor-γ coactivator (PGC-1α) biogenesis), electron transport chain complexes...
This study investigated cross-sectional associations of peripheral artery disease (PAD) severity (defined by the ankle-brachial index (ABI)) and amounts daily sustained physical activity (PA) as > 100 counts per minute lasting 5 consecutive minutes or more). also PA with 6-minute walk (6MW) distance Short Form-36 functioning domain (SF-36 PF) score in analyses serious adverse events (SAEs) longitudinal people PAD. was measured continuously for 10 days using a tri-axial accelerometer at...
Introduction: Lower income is associated with a higher prevalence of peripheral artery disease (PAD). However, whether lower faster rates mobility loss among people PAD unknown. This study describes associations in PAD. Methods: Data from four longitudinal studies participants conducted Chicago were combined (the Walking and Leg Circulation Study [WALCS] I, II, III the Biomarker Risk Assessment Vulnerable Outpatients [BRAVO] study). Participants an ankle brachial index (ABI) <0.90...
Objectives Modifiable physical activity (PA) plays an important role in dyslipidaemia risk middle-aged women with sleep problems, especially perimenopausal women. We aimed to explore the joint effects of and PA on aged 45–55 years, extent which moderated effect dyslipidaemia. Design A cross-sectional study. Setting This study was based survey Chronic Disease Nutrition Monitoring Adults Inner Mongolia 2015. Participants 721 years were included. Outcome measurement measured by Global Physical...