A5101560780- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Cardiac Fibrosis and Remodeling
- Heart Failure Treatment and Management
- Cancer-related gene regulation
- Cardiac pacing and defibrillation studies
- S100 Proteins and Annexins
- Cardiac Ischemia and Reperfusion
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Ion channel regulation and function
- Cardiovascular Health and Risk Factors
- Heart Rate Variability and Autonomic Control
- Cancer-related molecular mechanisms research
- ECG Monitoring and Analysis
- Cardiac Imaging and Diagnostics
- Psoriasis: Treatment and Pathogenesis
- Mechanisms of cancer metastasis
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
Qingdao University
2012-2025
Affiliated Hospital of Qingdao University
2012-2025
Renmin Hospital of Wuhan University
2015-2024
Wuhan University
2015-2024
Ningxia Medical University
2023
Shanghai Electric (China)
2023
Wuchang University of Technology
2018-2022
Shandong Maternal and Child Health Hospital
2020
Cardiovascular Institute Hospital
2020
Key Laboratory of Guangdong Province
2016
The short-chain fatty acid (SCFA) propionate (C3), a microorganism metabolite produced by gut microbial fermentation, has parasympathetic-activation effects. cardiac autonomic rebalancing strategy is considered as an important therapeutic approach to myocardial infarction (MI)-produced ventricular arrhythmias (VAs). Thus, our research was designed clarify the potential functions of SCFA in VAs and electrophysiology MI rats. A hundred adult Sprague-Dawley rats were allocated four groups: sham...
Abstract In our previous studies, we reported that myeloid differentiation protein 1 (MD1) serves as a negative regulator in several cardiovascular diseases. However, the role of MD1 heart failure with preserved ejection fraction (HFpEF) and underlying mechanisms its action remain unclear. Eight‐week‐old MD1‐knockout (MD1‐KO) wild‐type (WT) mice served models HFpEF induced by uninephrectomy, continuous saline or d‐aldosterone infusion 1.0% sodium chloride treatment drinking water for 4 weeks...
Abstract Myeloid differentiation 1 (MD-1), a secreted protein interacting with radioprotective 105 (RP105), plays an important role in Toll-like receptor 4 (TLR4) signalling pathway. Previous studies showed that MD-1 may be restricted the immune system. In this study, we demonstrated for first time was highly expressed both human and animal hearts. We also discovered cardiac-specific overexpression of significantly attenuated pressure overload-induced cardiac hypertrophy, fibrosis,...
The purpose of this study was to evaluate the cardiac electrophysiologic effects targeted ablation sympathetic neurons (TACSN) in a canine model chronic myocardial infarction (MI).Thirty-eight anaesthetized dogs were randomly assigned into sham-operated, MI, and MI-TACSN groups, respectively. Myocardial infarction-targeted neuron induced by injecting cholera toxin B subunit-saporin compound left stellate ganglion (LSG). Five weeks after surgery, function, heart rate variability (HRV),...
Abstract Triple‐negative breast cancer ( TNBC ) is a highly aggressive tumour subtype associated with poor prognosis. The mechanisms involved in progression remains largely unknown. To date, there are no effective therapeutic targets for this subtype. Paired‐related homeobox 1b (Prrx1b), one of major isoforms Prrx1, has been identified as new epithelial–mesenchymal transition EMT inducer. However, the function Prrx1b not elucidated. In study, we found that was significantly up‐regulated and...
Shensong Yangxin (SSYX) is a traditional Chinese medicine, which has been proven to improve the clinical symptoms of arrhythmia. However, role SSYX in metabolic syndrome (MetS)-induced electrical remodeling remains be fully elucidated. Here, we sought clarify whether can alter electrophysiological cardiac myocytes from MetS rats by regulating transient outward potassium current (Ito) and calcium (ICa-L). Male Wistar were subjected 16 weeks high-carbohydrate, high-fat produce model group....
Sodium-glucose cotransporter 2 inhibitors (SGLT2is) have made considerable progress in the field of heart failure, but their application arrhythmia remains to be in-depth. Right disease (RHD) often leads right dysfunction and is associated with atrial fibrillation (AF). Here, we explored possible electrophysiologic effect dapagliflozin (a type SGLT2is) development AF rats RHD.Rats experimental group were intraperitoneally injected a single dose 60 mg/kg monocrotaline (MCT group, n = 32) on...