A5100379352- Genomics, phytochemicals, and oxidative stress
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Retinal and Macular Surgery
- Cytokine Signaling Pathways and Interactions
- Adenosine and Purinergic Signaling
- TGF-β signaling in diseases
- Retinal Imaging and Analysis
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Advanced Glycation End Products research
- Connective Tissue Growth Factor Research
- Retinal Development and Disorders
- Sirtuins and Resveratrol in Medicine
- Amoebic Infections and Treatments
- Gout, Hyperuricemia, Uric Acid
- Vascular Malformations Diagnosis and Treatment
- Mesenchymal stem cell research
- Brain Tumor Detection and Classification
- GDF15 and Related Biomarkers
- Drug-Induced Ocular Toxicity
- Herpesvirus Infections and Treatments
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
First Affiliated Hospital of Xi'an Jiaotong University
2015-2025
Liaocheng University
2024-2025
Nanjing University
2017-2024
Nanjing General Hospital of Nanjing Military Command
2024
First Affiliated Hospital of Nanchang University
2024
Nanchang University
2024
First Affiliated Hospital of Jiangxi Medical College
2024
Zunyi Medical University
2023
Anhui University of Traditional Chinese Medicine
2023
Hubei University of Arts and Science
2021
Resveratrol is widely known for its antiaging properties and exerts cardiovascular protective effects in different experimental models. The role of resveratrol regulating mitochondrial functions dynamics during the cardiac aging process remains poorly understood. In this study, on morphology depolarization expressions Drp1, parkin, PINK1, LC3 were investigated H9c2 cells after D‐galactose treatment that induced senescent‐like cardiomyocytes. results show downregulation Drp1 markedly...
The segmentation of pathological fluid lesions in optical coherence tomography (OCT), including intraretinal fluid, subretinal and pigment epithelial detachment, is great importance for the diagnosis treatment various eye diseases such as neovascular age-related macular degeneration diabetic edema. Although significant progress has been achieved with rapid development fully convolutional neural networks (FCN) recent years, some important issues remain unsolved. First, OCT show large...
The Nuclear factor erythroid 2-related 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway has been extensively studied for its role in regulating antioxidant and antiviral responses. Equid herpesvirus type 8 (EqHV-8) poses a significant threat to the equine industry, primarily manifesting as respiratory disease, abortions, neurological disorders horses donkeys. Oxidative stress is considered key associated with pathogenesis of EqHV-8 infection. Unfortunately, there currently dearth...
Equine herpesvirus-1 (EHV-1) is a significant pathogen that causes substantial economic losses in the equine industry worldwide, which leads to severe respiratory diseases and abortions horses. However, reports of EHV-1 infection donkeys are limited, particularly China. This case study reported an EHV-1-induced disease Dezhou donkey foals Shandong Province, China, July 2024. Three one-month-old exhibited high fever, nasal discharge, distress, with 100% mortality rate. The causative agent,...
Nuclear factor erythroid 2-related 2 (Nrf2) is capable of inducing a variety biological effects, and the regulation Nrf2 signaling pathway closely related to longevity. To find out whether nuclear involved in oocyte aging or not which may cause reduced female fertility, series methods was applied, including collection culture, micro injection, RNA interference, western blotting, immunofluorescence confocal microscopy, quantitative real-time PCR.Our data demonstrated that depletion disrupted...
Acute myocardial infarction (AMI) is one of the most important causes mortality among patients with cardiovascular disease. Ginsenoside Rh2 plays a protective role in diseases. Furthermore, pyroptosis reportedly participates regulating occurrence and development AMI. However, whether ginsenoside contributes to mitigating AMI by cardiomyocyte remains unknown.In present study, we established an model rats. Next, determined effects on examining infarct area, while regulation was assessing...
Abstract Castration-resistant prostate cancer (CRPC), which is considered to contain stem cells (CSCs), leads a high relapse rate in patients with (PCa). However, the markers of CSCs are controversial. Here we demonstrate that CD51, part, correlates poor prognosis PCa patients. Further, find CD51 functional molecule able promote malignancy through enhancing tumor initiation, metastatic potential, and chemoresistance. Moreover, elevated expression specimens p53 loss function. Mechanistically,...
Natural products from plants have been proven to be important resources of antitumor agents. In this study, we exploited the activity (E)-3-(4-chlorophenyl)-N-(7-hydroxy-6-methoxy-2-oxo-2H-chromen-3-yl) acrylamide (SC-III3), a newly synthesized derivative scopoletin, by in vitro and vivo experiments. Human hepatocellular carcinoma cell line HepG2 cells xenograft BALB/c nude mice were used investigate effects SC-III3 on cancers. Cell cycle arrest apoptosis analyzed flow cytometry. arrest,...
Brusatol, a quassinoid isolated from the fruit of Bruceajavanica, has recently been shown to inhibit nuclear factor erythroid 2-related 2 (Nrf2) via Keap1-dependent ubiquitination and proteasomal degradation or protein synthesis. Nrf2 is transcription that regulates cellular defense response. Most studies have focused on effects in tumor development. Here, critical roles mouse early embryonic development were investigated. We found brusatol treatment at zygotic stage prevented embryo embryos...
Chlorogenic acid (CA) has been discovered to regulate macrophage polarization in pneumonia. This study aims analyze the functional mechanism of CA alveolar (AM) and provide a theoretical basis for treatment Klebsiella pneumoniae (Kp)-induced Mice were infected with Kp, treated silent information regulator 1 (SIRT1) inhibitor (Selisistat). Mouse survival rate was recorded bacterial burden detected. AM pathologic change lung tissues evaluated. Expressions SIRT1 HMGB1 cytokine levels MH-S cells...
Worldwide, neovascular age‑related macular degeneration (nAMD) is one of the most common causes blindness in elderly. In particular, retinal pigment epithelial (RPE) cells represents main pathological process development nAMD, and oxidative stress serves a major role. The present study aimed to investigate association between bone morphogenetic protein 6 (BMP‑6) nAMD. BMP‑6 concentration was significantly reduced patients with wet nAMD compared control group. Furthermore, investigated...
Cervical cancer ranks the fourth most prevalent type of worldwide, characterized by a notably low survival rate, particularly in its metastatic stage. Despite 5-aminolevulinic acid photodynamic therapy (ALA-PDT) demonstrating potential anti-tumor effects against cervical cancer, intricate mechanisms underlying efficacy necessitate further investigation. Here, study aims to elucidate impact ALA-PDT on cell viability, invasion and migration, alongside delineating molecular mechanisms. SiHa...
Fengshi Gutong Capsule (FSGTC) is a commonly used Chinese medicine for the treatment of joint pain caused by osteoarthritis (OA). However, mechanism action FSGTC OA remains unclear.This study aimed to explore alleviating effects and potential mechanisms through data mining, network pharmacology, in vitro experiments.High-performance liquid chromatography (HPLC) was performed establish fingerprints detect components absorbed blood. The on inflammation, immunity, liver kidney functions...
Retinal progenitor cells (RPCs) remain in the eye throughout life and can be characterized by their ability for self-renewal as well specialization into different cell types. A recent study has suggested that metabotropic glutamate receptors (mGluRs) participate processes of multiple types stem cells. Therefore, clarifying functions subtypes mGluRs RPCs may provide a novel treatment strategy regulating proliferation differentiation endogenous after retinal degeneration. In this study, we...
To investigate the expression of transcription factors Slug in human lens epithelial cells (HLECs) undergoing epithelial-mesenchymal transition (EMT) induced by connective tissue growth factor (CTGF).HLECs were treated with CTGF different concentrations (20, 50 and 100 ng/mL) or without (control) for 24h. The morphological changes HLECs analysed microscopy. cellular localization was evaluated immumo-fluorescence. Expressions Slug, E-cadherin alpha smooth muscle actin (α-SMA) further...
AIM: To investigate the effect of high concentration glucose (HCG) on double stranded RNA-activated protein kinase-like ER kinase (PERK)-eukaryotic initiation factor-2α (eIF2α)-transcription factor C/EBP homologous (CHOP)-cysteine aspartate specific proteinase (caspase-12) signaling pathway activation and apoptosis in rabbit corneal epithelial cells (RCECs). METHODS: RCECs were treated by different concentrations for 0-48h. The expressions PERK, p-PERK, eIF2α, p-eIF2α, 78 kDa...
AIM: To evaluate the effect of bone morphogenetic protein-6 (BMP-6) on transforming growth factor (TGF)-β2-induced epithelial-mesenchymal transition (EMT) in retinal pigment epithelium (RPE). METHODS: Adult epithelial cell line (ARPE-19) were randomly divided into control, TGF-β2 (5 µg/L), and BMP-6 small interfering RNA (siRNA) group. The morphology was observed by microscopy, migration ability detected Transwell chamber. EMT-related indexes protein levels Western blotting. Furthermore, a...