A5102495076- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Digital Media Forensic Detection
- Ovarian cancer diagnosis and treatment
- Image Processing Techniques and Applications
- Advanced Vision and Imaging
- Handwritten Text Recognition Techniques
- PI3K/AKT/mTOR signaling in cancer
- Cytokine Signaling Pathways and Interactions
- Genomics, phytochemicals, and oxidative stress
- Ion channel regulation and function
- Advanced Nanomaterials in Catalysis
- Image Processing and 3D Reconstruction
- Ion Channels and Receptors
- Computer Graphics and Visualization Techniques
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Smart Grid and Power Systems
- Ion Transport and Channel Regulation
- Nanocluster Synthesis and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Mast cells and histamine
- Multimodal Machine Learning Applications
- 3D Shape Modeling and Analysis
Duke Medical Center
2016-2025
Zhejiang University
2024
First Affiliated Hospital of Jiangxi Medical College
2024
First Affiliated Hospital of Nanchang University
2022-2024
Nanchang University
2022-2024
Fujian Medical University
2022-2024
South China University of Technology
2022-2024
Hainan Medical University
2022
Hainan General Hospital
2022
Xuzhou Medical College
2015-2020
T follicular helper (Tfh) cells play critical roles for germinal center responses and effective humoral immunity. We report here that mTOR in CD4 is essential Tfh differentiation. In Mtorf/f-Cd4Cre mice, both constitutive inducible differentiation severely impaired, leading to defective B cell formation antibody production. Moreover, mTORC1 mTORC2 contribute GC development but may do so via distinct mechanisms. mainly promotes proliferation reach the divisions necessary differentiation,...
Voltage‐gated sodium channels (VGSCs), which are aberrantly expressed in several human cancers, affect cancer cell behavior; however, their role gastric (GC) and the link between these tumorigenic signaling remain unclear. The aims of this study were to determine clinicopathological significance VGSC Na v 1.7 GC progression investigate associated mechanisms. Here, we report that SCN9A gene encoding was most abundantly subtype tissue samples two lines (BGC‐823 MKN‐28 cells). expression levels...
We report herein a new kind of water-soluble gold nanoclusters (AuNCs) for enzyme-activatable charge transfer, based on the ligand engineering AuNCs with 6-mercaptopurine ribonucleoside (MPR).
Regulatory T cells (Tregs) actively engage in immune suppression to prevent autoimmune diseases but also inhibit anti-tumor immunity. Although Tregs express a TCR repertoire with relatively high affinities self, they are normally quite stable and their inflammatory programs intrinsically suppressed. We report here that diacylglycerol (DAG) kinases (DGK) ( crucial for homeostasis, of proinflammatory programs, stability enforcing dependence on CD28 costimulatory signal. Treg-specific...
Regulatory T cells (Tregs) actively engage in immune suppression to prevent autoimmune diseases but also inhibit anti-tumor immunity. Although Tregs express a TCR repertoire with relatively high affinities self, they are normally quite stable and their inflammatory programs intrinsically suppressed. We report here that diacylglycerol (DAG) kinases (DGK) ( crucial for homeostasis, of proinflammatory programs, stability enforcing dependence on CD28 costimulatory signal. Treg-specific...
Fatty acid synthase (FASN), a lipogenic multi-enzyme complex, is reported to be overexpressed in various types of tumor tissues and serves an important role development progression. However, the expression FASN its possible gastric cancer (GC) remains defined. In present study, group sample 167 GC was detected by immunohistochemistry correlation with clinicopathological features analyzed. By clinical analysis, it identified that overexpression positively correlated overall survival [P=0.008;...
// Jialong Yang 1 , Ping Zhang Sruti Krishna Jinli Wang 2 Xingguang Lin Hongxiang Huang 1,3 Danli Xie 1,2 Balachandra Gorentla Rick Jimin Gao Qi-Jing Li 4 and Xiao-Ping Zhong 1,4 Department of Pediatrics, Division Allergy Immunology, Duke University Medical Center, Durham, NC, USA School Laboratory Medicine, Wenzhou University, Wenzhou, Zhejiang, China 3 Oncology, Nanfang Hospital, Southern Guangzhou, Guangdong, Correspondence to: email: Keywords : DGK, miR-155, NFκB, CD8 T cell, Listeria...
In order to examine new ideas for gene therapy in ovarian cancer, the specific mechanism underlying effects of WW domain containing oxidoreductase (WWOX) on cell cycle regulation and apoptosis human cancer stem cells was investigated. Ovarian were transfected with a eukaryotic expression vector carrying WWOX vitro (recombinant plasmid) empty plasmid (empty or untransfected used as controls. Stably screened amplified culture protein detected by western blot analysis three groups cells....
The study of ancient writings has great value for archaeology and philology. Essential forms material are photographic characters, but manual character recognition is extremely time-consuming expertise-dependent. Automatic classification therefore greatly desired. However, the current performance limited due to lack annotated data. Data generation an inexpensive useful solution data scarcity. Nevertheless, diverse glyph shapes complex background textures characters make task difficult,...
The expression of E74-like factor 5 (ELF5) in epithelial ovarian carcinoma tissues and its effects on biological behavior cells were assessed search for a new approach gene treatment carcinoma. RT-PCR technology was applied to detect the ELF5 mRNA (n=49), borderline tumor (n=19), benign (n=31) normal (n=40). Then, we transfected recombinant plasmid pcDNA3.1‑ELF5+EGFP into human SKOV3 (recombinant group) vitro screened out stably conduct multiplication culture. Western blot analysis performed...
The aim of the present study was to examine clinical value 'tying, binding and fixing operation' in treating severe mixed hemorrhoids. A total 160 patients with hemorrhoids were selected randomly divided into experimental (n=80) control groups. groups treated using Doppler ultrasound-guided hemorrhoidal artery ligation (DG-HAL), respectively. results showed that average operative time group (35.57±6.17) significantly higher than (12.73±4.92). There no significant difference blood loss during...
Abstract T-cells play an important role in promoting mucosal immunity against pathogens, but the mechanistic basis for their homeostasis intestine is still poorly understood. We report here that T-cell-specific deletion of mTOR results dramatically decreased CD4 and CD8 T-cell numbers lamina propria both small large intestines under steady-state inflammatory conditions. These defects result defective host resistance a murine enteropathogen, Citrobacter rodentium , leading to death animals....
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) combined with cytotoxic chemotherapy are highly effective in the treatment of advanced non-small-cell lung cancer (NSCLC) EGFR mutations. The purpose this study is to evaluate efficacy and safety combination NSCLC patients an EGFR/TP53 co-mutation.Ninety-five co-mutation were enrolled study. Treatments either EGFR-TKI monotherapy (T group, n = 61) or (TC 34) evaluated relation objective response rate (ORR), disease...
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Cervical cancer ranks the fourth most prevalent type of worldwide, characterized by a notably low survival rate, particularly in its metastatic stage. Despite 5-aminolevulinic acid photodynamic therapy (ALA-PDT) demonstrating potential anti-tumor effects against cervical cancer, intricate mechanisms underlying efficacy necessitate further investigation. Here, study aims to elucidate impact ALA-PDT on cell viability, invasion and migration, alongside delineating molecular mechanisms. SiHa...
The generation of global illumination in real time has been a long-standing challenge the graphics community, particularly dynamic scenes with complex illumination. Recent neural rendering techniques have shown great promise by utilizing networks to represent and then decoding final radiance. However, incorporating object parameters into representation may limit their effectiveness handling fully scenes. This work presents approach, dubbed LightFormer , that can generate realistic for...
Hard negative generation aims to generate informative samples that help determine the decision boundaries and thus facilitate advancing deep metric learning. Current works select pair/triplet samples, learn their correlations, fuse them hard negatives. However, these merely consider local correlations of selected ignoring global sample would provide more significant information In this work, we propose a Globally Correlation-Aware Negative Generation (GCA-HNG) framework, which first learns...
Abstract Regulatory T cells (Tregs) actively engage in immune suppression to prevent autoimmune diseases but also inhibit anti-tumor immunity. Although Tregs express a TCR repertoire with relatively high affinities self, they are normally quite stable and their inflammatory programs intrinsically suppressed. We report here that diacylglycerol (DAG) kinases (DGK) ( crucial for homeostasis, of proinflammatory programs, stability enforcing dependence on CD28 costimulatory signal. Treg-specific...